Neuroscience is the scientific study of the nervous system. Traditionally, neuroscience is recognized as a branch of biology.
A neuron is an electrically excitable cell that processes and transmits information through electrical and chemical signals. These signals between neurons occur via synapses, specialized connections with other cells. Neurons can connect to each other to form neural networks. Neurons are the core components of the brain and spinal cord of the central nervous system (CNS), and of the ganglia of the peripheral nervous system (PNS).
All neurons are electrically excitable, maintaining voltage gradients across their membranes by means of metabolically driven ion pumps, which combine with ion channels embedded in the membrane to generate intracellular-versus-extracellular concentration differences of ions such as sodium, potassium, chloride, and calcium. Changes in the cross-membrane voltage can alter the function of voltage-dependent ion channels. If the voltage changes by a large enough amount, an all-or-none electrochemical pulse called an action potential is generated, which travels rapidly along the cell's axon, and activates synaptic connections with other cells when it arrives.
MI 192是活性的,选择性HDAC2/3抑制剂。
MoreL-685,458是活性选择性的 γ-secretase 抑制剂。
MoreJLK 6是γ-secretase-mediated βAPP processing抑制剂。
MoreYO-01027是一种二肽γ-secretase抑制剂,抑制APPL和Notch分裂, IC50分别为2.6 nM和2.9 nM。
MoreGivinostat (ITF2357)是一种有效的HDAC抑制剂,作用于HDAC2, HDAC1B和HDAC1A时,IC50分别为10 nM, 7.5 nM和16 nM。
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