Home > 暂无记录 Signal Pathway > Metabolism

Metabolism


Metabolism is the set of life-sustaining chemical transformations within the cells of living organisms. The three main purposes of metabolism are the conversion of food/fuel to energy to run cellular processes, the conversion of food/fuel to building blocks for proteins, lipids, nucleic acids, and some carbohydrates, and the elimination of nitrogenous wastes. These enzyme-catalyzed reactions allow organisms to grow and reproduce, maintain their structures, and respond to their environments. 

  • SB203580 EY0411

    SB203580, a selective inhibitor of p38MAPK, controls the various inflammatory responses and cellular stresses. SB203580是一种p38 MAPK抑制剂，IC50为0.3-0.5 μM，与SAPK3(106T)和SAPK4(106T)相比选择性低10倍，且抑制PKB磷酸化，IC50为3-5 μM。

    More

  • Cryptotanshinone EY0355

    Cryptotanshinone是一种STAT3抑制剂，抑制STAT3 Tyr705磷酸化，对STAT3 Ser727作用效果弱，对STAT1和STAT5没有作用效果。

    More

  • Niclosamide EY0323

    Niclosamide, an FDA approved anthelmintic drug, is an inhibitor of Wnt co-receptor LRP6 and suppresses both the Wnt/β-catenin pathways and the mTOR/STAT3 pathway. Niclosamide抑制DNA复制，抑制STAT，IC50为0.7 μM。

    More

  • Fludarabine EY0005

    Fludarabine, a purine analog, is used in the treatment of hematological malignancies for the inhibition of STAT-1 activation and DNA synthesis. Fludarabine是一种STAT1活性抑制剂和DNA合成抑制剂。

    More

  • Cucurbitacin I EY2197

    Selective inhibitor of STAT3/JAK2 signaling. Inhibits the activation of STAT3 and JAK2 and displays no activity on Src, Akt, ERK and JNK. Suppresses phosphotyrosine levels of STAT3, inhibits STAT3 DNA binding and STAT3-mediated gene expression. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3.

    More
    • Current page42, Total Pages51, Total Record252 First Prev 4041424344 Next Last Goto
More