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Aripiprazole

阿立哌唑,OPC-14597,OPC14597,OPC 14597,

Aripiprazole是一种人5-HT1A受体激动剂，Ki为4.2 nM。

目录号
EY1816
EY1816
EY1816
纯度
99.49%
99.49%
99.49%
规格
100 mg
500 mg
1 g
原价
590
1020
1410
售价
590
1020
1410
库存
现货
现货
现货
订购
订购
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  • 生物活性

    Aripiprazole is a novel atypical antipsychotic drug that is reported to be a high-affinity 5-HT receptor partial agonist.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Burris KD, et al. J Pharmacol Exp Ther, 2002, 302(1), 381-389.

    分子式
    C23H27Cl2N3O2    		 分子量
    448.39    		 CAS号
    129722-12-9    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    90 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00468130 Autism Drug: Aripiprazole University of Medicine and Dentistry of New Jersey|Rutgers, The State University of New Jersey 2006-05-01 2014-09-23
    NCT01001702 Schizophrenia Drug: Aripiprazole Otsuka Pharmaceutical Development & Commercialization, Inc. Phase 3 2006-04-01 2013-07-29
    NCT00276978 Therapy-resistant Depression Drug: Aripiprazole University Hospital Freiburg Phase 3 2005-06-01 2016-05-12
    NCT02501109 Schizophrenia Drug: Aripiprazole CMG Pharmaceutical Co. Ltd Phase 1 2015-10-01 2016-03-23
    NCT00497055 Substance Abuse|HIV Infections Drug: Aripiprazole|Drug: Placebo San Francisco Department of Public Health|National Institute on Drug Abuse (NIDA) Phase 2 2009-03-01 2014-02-05
    NCT00947154 Trichotillomania Drug: aripiprazole Stanford University 2009-07-01 2015-05-31
    NCT01727713 Tourette's Disorder|Tic Disorder Drug: Aripiprazole Otsuka Pharmaceutical Development & Commercialization, Inc. Phase 3 2013-01-01 2015-09-17
    NCT00198055 Asperger's Disorder|Pervasive Developmental Disorder Drug: aripiprazole Indiana University School of Medicine|Bristol-Myers Squibb|Indiana University Phase 2 2005-01-01 2014-06-03
    NCT02069977 Autism Drug: Aripiprazole Yoo-Sook Joung|Korea Otsuka International Asia Arab|Samsung Medical Center Phase 4 2014-02-01 2014-03-10
    NCT00374348 Schizophrenia OCD|Obsessive Compulsive Disorder Drug: Aripiprazole Jamaica Hospital Medical Center|Bristol-Myers Squibb|Department of Psychiatry, Jamaica Hospital Medical Center|Research Division 2005-03-01 2011-09-15
    NCT00220636 Depressive Disorder, Major Drug: Aripiprazole St. Luke's-Roosevelt Hospital Center|Bristol-Myers Squibb Phase 4 2005-03-01 2016-04-26
    NCT00208533 Autism Drug: Aripiprazole Drexel University College of Medicine|Drexel University Phase 2 2004-02-01 2017-02-22
    NCT00308074 Autism|Asperger's Disorder|Pervasive Developmental Disorder Drug: Aripiprazole Cambridge Health Alliance|Bristol-Myers Squibb Phase 2 2006-02-01 2016-12-30
    NCT01338298 Hyperprolactinemia Drug: Aripiprazole|Drug: Placebo University of Maryland 2011-01-01 2017-03-16
    NCT00556140 Psychotic Depression Drug: Aripiprazole Massachusetts General Hospital|Bristol-Myers Squibb Phase 3 2003-06-01 2012-07-11
    NCT00705783 Schizophrenia Drug: Aripiprazole depot|Drug: Placebo depot Otsuka Pharmaceutical Development & Commercialization, Inc. Phase 3 2008-07-01 2013-06-16
    NCT00683852 Major Depressive Disorder Drug: Aripiprazole|Drug: Aripiprazole|Drug: Placebo Massachusetts General Hospital|Bristol-Myers Squibb Phase 3 2008-07-01 2010-08-11
    NCT01714011 Schizophrenia Drug: Ziprasidone|Drug: Aripiprazole University of Malaya Phase 4 2009-05-01 2012-11-26
    NCT01416441 Tourette's Disorder Drug: aripiprazole Otsuka Pharmaceutical Development & Commercialization, Inc. Phase 3 2011-08-01 2015-03-25
    NCT02697045 Schizophrenia Drug: Aripiprazole 400mg LAI Abdi brahim Otsuka Phase 4 2016-04-01 2016-02-26
    NCT00102063 Schizophrenia Drug: Aripiprazole tablet, 10 mg|Drug: Aripiprazole tablet, 30 mg|Drug: Placebo tablet Otsuka Pharmaceutical Development & Commercialization, Inc. Phase 3 2004-07-01 2012-08-06
    NCT01552772 Schizophrenia Drug: Aripiprazole IM Depot Otsuka Pharmaceutical Development & Commercialization, Inc. Phase 1 2012-01-01 2014-10-08
    NCT00608543 Major Depressive Disorder Drug: Aripiprazole University of Texas Southwestern Medical Center|Bristol-Myers Squibb Phase 4 2005-10-01 2012-10-24
    NCT01509053 Schizophrenia Drug: Aripiprazole (Abilify) IM Depot Injection|Drug: Oral aripiprazole Otsuka Pharmaceutical Development & Commercialization, Inc. Phase 3 2012-01-01 2015-02-12
    NCT00194038 Bipolar Disorder Drug: Aripiprazole University Hospitals Cleveland Medical Center|Bristol-Myers Squibb Phase 4 2004-04-01 2014-12-16

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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