Home > 5-HT Receptor & 5-HT Receptor & > Palonosetron HCl

Palonosetron HCl

盐酸帕洛诺司琼,RS-25259,RS-25259-197,RS25259,RS 25259,

Palonosetron是5-HT3拮抗剂，能抑制化疗引起的恶心呕吐（CINV）。

目录号
EY1800
EY1800
EY1800
纯度
99.14%
99.14%
99.14%
规格
50 mg
100 mg
200 mg
原价
540
920
1420
售价
540
920
1420
库存
现货
现货
现货
订购
订购
订购
订购
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  • 生物活性

    Palonosetron HCl is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Wong EH, et al. Br J Pharmacol, 1995, 114(4), 851-859.

    分子式
    C19H25ClN2O    		 分子量
    332.87    		 CAS号
    135729-62-3    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    <1 mg/mL    		 Water
    200 mM    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00900757 Malignant Glioma Drug: Palonosetron (PALO) Duke University|Eisai Inc.|National Institute of Neurological Disorders and Stroke (NINDS) Phase 2 2009-08-01 2014-11-03
    NCT01046240 Emesis Drug: Palonosetron Clinica Universidad de Navarra, Universidad de Navarra Phase 1|Phase 2 2009-10-01 2015-01-26
    NCT00982995 Nausea|Vomiting|Terminally Ill Drug: Palonosetron University of Michigan Cancer Center Phase 2 2010-11-01 2015-11-05
    NCT01650961 Anesthesia, General|Palonosetron Drug: Palonosetron|Drug: Normal saline Seoul National University Hospital 2012-07-01 2013-08-06
    NCT02205164 Chemotherapy Induced Nausea and Vomiting Drug: Palonosetron + Aprepitant|Drug: Palonosetron Associazione Salentina Angela Serra Phase 2 2011-10-01 2014-07-30
    NCT00636805 Brain Cancer Drug: Palonosetron (Aloxi) and Dexamethasone Duke University|Eisai Inc.|National Institute of Neurological Disorders and Stroke (NINDS) Phase 2 2008-05-01 2014-03-04
    NCT00412425 Melanoma Drug: Palonosetron M.D. Anderson Cancer Center|Eisai Inc. Phase 1|Phase 2 2006-11-01 2012-04-09
    NCT02941913 Postoperative Nausea and Vomiting Drug: palonosetron Instituto Nacional de Cancer, Brazil Phase 4 2016-10-01 2016-10-19
    NCT01952626 Morphine Adverse Reaction Drug: Ondansetron|Drug: Palonosetron Kyungpook National University 2013-04-01 2015-04-07
    NCT02532634 Cancer|Tumors Drug: ramosetron, aprepitant, dexamethasone|Drug: palonosetron, aprepitant, dexamethasone Kangdong Sacred Heart Hospital|The Catholic University of Korea|Astellas Pharma Korea, Inc. Phase 4 2015-08-01 2016-08-30
    NCT01568268 Laparoscopic Gynecologic, Abdominal, Other Surgery|General Anesthesia Drug: Palonosetron|Drug: placebo control group Samsung Medical Center|CJ HealthCare Corporation Phase 3 2012-01-01 2013-12-24
    NCT00828295 Postoperative Nausea and Vomiting Drug: palonosetron|Drug: palonosetron Helsinn Healthcare SA Phase 3 2008-08-01 2015-03-17
    NCT01370408 Chemotherapy-induced Nausea and Vomiting Drug: Palonosetron|Drug: ondansetron|Drug: Dexamethasone Northside Hospital, Inc.|Blood and Marrow Transplant Group of Georgia Phase 2 2012-02-01 2016-12-12
    NCT00410488 Sarcoma|Nausea|Vomiting Drug: Palonosetron - Single Dose|Drug: Palonosetron - Triple Dose|Drug: Adriamycin|Drug: Ifosfamide chemotherapy (AI)|Drug: Zinecard|Drug: Mesna|Drug: Vincristine|Drug: Dexamethasone M.D. Anderson Cancer Center|Eisai Inc. 2006-12-01 2013-02-19
    NCT01031498 Acute Myelogenous Leukemia|Chemotherapy-induced Nausea and Vomiting Drug: Ondansetron|Drug: Palonosetron M.D. Anderson Cancer Center|Eisai Inc. Phase 2 2005-09-01 2012-08-01
    NCT03040726 In Situ Neoplasm|Malignant Neoplasms|Nausea and Vomiting, Chronic Drug: Netupitant / Palonosetron|Other: Placebo|Behavioral: Symptom Questionnaires|Behavioral: Patient Diary M.D. Anderson Cancer Center|Helsinn Healthcare SA Phase 2|Phase 3 2017-05-01 2017-03-16
    NCT02388750 Nausea|Vomiting Drug: Palonosetron|Radiation: Low or moderate risk radiotherapy Dr. Edward Chow|Sunnybrook Health Sciences Centre Phase 2 2015-04-01 2016-04-14
    NCT01395901 Postoperative Nausea and Vomiting Drug: Palonosetron|Drug: Ondansetron|Drug: Placebo to Ondansetron|Drug: Placebo to Palonosetron Helsinn Healthcare SA Phase 3 2011-06-01 2014-07-29
    NCT02970643 Chemotherapy-induced Nausea and Vomiting Drug: Olanzapine|Drug: Palonosetron Hee Jun Kim|CJ HealthCare Corporation|Chung-Ang University Hosptial, Chung-Ang University College of Medicine 2016-07-01 2016-11-22
    NCT00967499 Postoperative Nausea and Vomiting Drug: ondansetron|Drug: palonosetron Eisai Inc. Phase 2 2009-07-01 2010-05-06
    NCT02468323 PONV Drug: Placebo|Drug: Ondansetron|Drug: Palonosetron Hospital de Base Phase 4 2015-10-01 2017-03-08
    NCT03008213 Chemotherapy Induced Nausea Vomiting Drug: Netupitant and Palonosetron University of California, San Diego Phase 2 2017-01-01 2016-12-29
    NCT01442376 Chemotherapy-Induced Nausea and Vomiting Drug: Palonosetron|Drug: Palonosetron|Drug: Ondansetron|Drug: Placebo to Ondansetron|Drug: Placebo to Ondansetron|Drug: Placebo to Palonosetron Helsinn Healthcare SA Phase 3 2011-09-01 2014-08-04

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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