Home > 暂无记录 Signal Pathway > JAK/STAT

JAK/STAT


The JAK-STAT signaling pathway transmits information from extracellular chemical signals to the nucleus resulting in DNA transcription and expression of genes involved in immunity, proliferation, differentiation, apoptosis and oncogenesis. The JAK-STAT signalling cascade consists of three main components: a cell surface receptor, a Janus kinase (JAK) and two Signal Transducer and Activator of Transcription (STAT) proteins. Disrupted or dysregulated JAK-STAT functionality can result in immune deficiency syndromes and cancers.

  • SL-327 EY1528

    SL-327是可渗透入细胞的MEK-1和MEK-2抑制剂，IC50分别为180nM和220nM。

    More

  • Binimetinib EY1377

    MEK162(ARRY-438162; ARRY-162)是MEK1/2抑制剂，IC50为12 nM。

    More

  • Pimasertib EY1315

    Pimasertib (AS-703026)作用于MM细胞系，是一种高度选择性的，有效的，ATP非竞争性的，MEK1/2变构抑制剂，IC50为0.005-2 μM。

    More

  • AZD8330 EY1091

    AZD8330是一种新型，选择性的，非ATP竞争性MEK 1/2抑制剂，IC50为7 nM。

    More

  • Refametinib EY1043

    Refametinib是口服生物相容性的MEK抑制剂，对MEK1和MEK2的IC50分别为19 nM和47 nM，有抗肿瘤活性。

    More
    • Current page4, Total Pages5, Total Record24 First Prev 12345 Next Last Goto
More