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Bevacizumab (Avastin), an antiangiogenic anti-VEGF-R monoclonal antibody specifically binds to all VEGF-A isoforms with high affinity, has a rapid impact on tumor-related brain edema in recurrent GB.
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Brentuximab vedotin (SGN-35), a CD30-directed antibody-drug conjugate composed of an anti-CD30 monoclonal antibody linked to the microtubule-disrupting agent, is approved for treating certain patients with CD30-expressing hematologic malignancies.
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Canakinumab, a high-affinity human monoclonal anti IL-1β antibody, neutralizing IL-1β-mediated pathways, is approved for treatment of systemic juvenile idiopathic arthritis (SJIA).
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Certolizumab pegol is a TNF-α antagonist that lacks the Fc portion of the IgG antibody, widely used for the treatment of the inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.
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Cetuximab, an anti-EGFR monoclonal antibody, is used for the treatment of unresectable advanced or recurrent head and neck or colorectal cancer.
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