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Other Singal pathway


  • SCR7 pyrazine EY5006

    SCR7 pyrazine is an inhibitor of DNA ligase IV that blocks non-homologous end joining (NHEJ) in a ligase IV‑dependent manner. SCR7 pyrazine enhances the efficiency of Cas9‑mediated homology‑directed repair (HDR). SCR7 pyrazine induces apoptosis and exhibits anticancer activity.

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  • RI-1 EY5005

    RI-1 (RAD51 inhibitor 1) is a RAD51 inhibitor with an IC₅₀ of 5 to 30 µM.

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  • Mirin EY5004

    Mirin is a potent inhibitor of the Mre11–Rad50–Nbs1 (MRN) complex and can inhibit Mre11-associated exonuclease activity. Mirin suppresses MRN-dependent activation of ATM.

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  • AZD-7648 EY5003

    AZD‑7648 是一种高选择性、口服有效的 DNA‑PK 抑制剂，IC50 值为 0.6 nM。AZD‑7648 可诱导细胞凋亡（apoptosis），并具有抗肿瘤活性。

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  • B02 EY5002

    B02 是一种人源 RAD51 小分子抑制剂，IC50 为 27.4 μM，对大肠杆菌中的同源蛋白 RecA 无抑制作用（IC50＞250 μM）。

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