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Other Singal pathway


  • 6-(Dimethylamino)purine EI3035

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  • THAL-SNS-032 EY8043

    THAL-SNS-032 是一种选择性的 Cyclin-dependent kinase 9 (CDK9) 的降解剂PROTAC，包含一个与CDK结合的SNS-032配体、一个thalidomide衍生物和 E3 ubiquitin ligase Cereblon (CRBN)相结合

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  • Simurosertib EY8042

    Simurosertib (TAK-931) 是一种具有口服活性，选择性， ATP 竞争性的细胞分裂周期 7 (CDC7) 激酶抑制剂，IC50 为 <0.3 nM。Simurosertib 具有抗癌活性。

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  • Tucatinib EY8041

    Tucatinib (Irbinitinib, ONT-380, ARRY-380) 是一种具有口服活性、可逆的、ATP竞争性的的ErbB2（HER2）小分子抑制剂。在细胞实验中，ARRY-380对ErbB-2和p95 HER2的IC50s分别为8 nM和7 nM，对HER2的选择性是对EGFR的500倍。具有潜在的抗肿瘤活性。

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  • C188-9 EY8040

    C188-9 (TTI 101) is an effective STAT3 inhibitor that binds to STAT3 with high affinity, with a dissociation constant (Kd) of 4.7±0.4 nM. C188-9 is well tolerated in mice and exhibits good oral bioavailability, mainly accumulating in tumor tissues.

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