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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • MK-886 EY5645

    MK-886 is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist.

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  • NXT629 EY5417

    Nxt629 is an effective, selective and competitive PPAR- α Antagonists, human PPAR α The IC50 value of is 77 nm, which is more selective than other nuclear hormone receptors, such as ppar δ， PPAR γ， Er β， GR and tr β， IC50 values are 6.0, 15, 15.2, 32.5 and >100 respectively μ M。

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  • RG7713 EY4823

    RG7713 is a highly potent and selective Brain-Penetrant Vasopressin 1a (V1a) receptor antagonist with Kis of 1 nM (hV1a) and 39 nM (mV1a).

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  • PF-3084014 EY5327

    PF-3084014 is a reversible, noncompetitive, and selective γ-secretase inhibitor with IC50 of 6.2 nM.

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  • Indinavir EY6002

    Indinavir is a member of the novel hydroxyaminopentane amide class of HIV-1 protease inhibitors.

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