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D-I03 is a selective inhibitor of RAD52 with a Kd value of 25.8 µM.
D-I03 inhibits ssDNA annealing via RAD52 and D-loop formation, with IC50 values of 5 µM and 8 µM, respectively.
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SCR7 pyrazine is an inhibitor of DNA ligase IV that blocks non-homologous end joining (NHEJ) in a ligase IV‑dependent manner. SCR7 pyrazine enhances the efficiency of Cas9‑mediated homology‑directed repair (HDR). SCR7 pyrazine induces apoptosis and exhibits anticancer activity.
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Mirin is a potent inhibitor of the Mre11–Rad50–Nbs1 (MRN) complex and can inhibit Mre11-associated exonuclease activity. Mirin suppresses MRN-dependent activation of ATM.
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THAL-SNS-032 是一种选择性的 Cyclin-dependent kinase 9 (CDK9) 的降解剂PROTAC，包含一个与CDK结合的SNS-032配体、一个thalidomide衍生物和 E3 ubiquitin ligase Cereblon (CRBN)相结合
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