参考文献
[1] Kuwano et al (2007) 2-[4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy]-N-(methylsulfonyl)acetamide (NS-304), an orally available and long-acting prostacyclin receptor agonist prodrug. J.Pharmacol.Exp.Ther. 322 1181. PMID: 17545310.
[2] Kuwano et al (2008) A long-acting and highly selective prostacyclin receptor agonist prodrug, 2-{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), ameliorates rat pulmonary hypertension with unique relaxant responses of its active form, {4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}acetic acid (MRE-269), on rat pulmonary artery. J.Pharmacol.Exp.Ther. 326 691. PMID: 18552131.
[3] Morrison et al (2010) Selexipag: a selective prostacyclin receptor agonist that does not affect rat gastric function. J.Pharmacol.Exp.Ther. 335 249. PMID: 20660124.
分子式
C26H32N4O4S |
分子量
496.62 |
CAS号
475086-01-2 |
储存方式
﹣20 ℃长期储存。冰袋运输 |
溶剂（常温）
|
DMSO
100 mM |
Water
|
Ethanol
|
体内溶解度
