生物活性

AEBSF is a broad spectrum, water soluble, irreversible serine protease inhibitor. It has been shown to inhibit the constitutive production of beta amyloid (A beta) in five different human cell lines, both neural and non-neural. Also inhibits NADPH oxidase activation in vitro. Attenuates airway inflammation in a mouse model of airway allergy. AEBSF is a b-secretase inhibitor that has been shown to inhibit beta amyloid peptide production and enhance APP (amyloid precursor protein) secretion in several cell lines at millimolar concentrations. This product maintains stability at slightly acidic aqueous solutions and serves as a nontoxic alternative to PMSF and DFP.

体外研究

体内研究

激酶实验

细胞实验

动物实验

~76.8 mg/kg，每天腹腔注射

不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

参考文献

[1] Citron M, et al. Neuron. 1996, 17(1), 171-179.
[2] Lawson, W.B., et al. 1982. Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. 109: 52-60.
[3] Ohkubo, I., et al. 1994. J. Biochem. 116: 1182-1186.
[4] Solovyan, V.T. and Keski-Oja, J. 2006. J. Cell. Physiol. 207: 445-453.
[5] Seto, T., et al. 2009. Biochem. Biophys. Res. Commun. 379: 681-685.

体内溶解度

Clinical Trial Information ( data from http://clinicaltrials.gov )

注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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