Atovaquone用于治疗或预防肺孢子菌肺炎,弓形虫病,疟疾和巴贝西虫。
Atovaquone is a medication used to treat or prevent for pneumocystis pneumonia, toxoplasmosis, malaria, and babesia.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Looareesuwan S, et al. Am J Trop Med Hyg, 1996, 54(1), 62-66.
[2] El-Sadr, W.M., et al.: N. Engl. J. Med., 339, 1889 (1998)
分子式 C22H19ClO3 |
分子量 366.84 |
CAS号 95233-18-4 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 5.1 mg/mL |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02628080 | Carcinoma, Non-Small-Cell Lung | Drug: Atovaquone | University of Oxford | Early Phase 1 | 2016-05-01 | 2016-06-21 |
NCT01858831 | Malaria | Drug: Atovaquone/proguanil HCL|Drug: Atovaquone | GlaxoSmithKline | Phase 1 | 2012-04-01 | 2017-03-21 |
NCT02297477 | Malaria | Drug: atovaquone-proguanil|Drug: artesunate-atovaquone-proguanil | Armed Forces Research Institute of Medical Sciences, Thailand|National Centre for Parasitology, Entomology and Malaria Control, Cambodia|Naval Medical Research Center, Asia (NMRC-A) | Phase 4 | 2014-12-01 | 2016-01-10 |
NCT00000773 | Pneumonia, Pneumocystis Carinii|HIV Infections | Drug: Atovaquone | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 1 | null | 2012-03-30 |
NCT00984256 | Malaria | Drug: Atovaquone Proguanil|Other: Procedure - malaria challenge | U.S. Army Medical Research and Materiel Command | Phase 2 | 2009-09-01 | 2013-10-29 |
NCT00421473 | HIV Infections|Malaria | Drug: Atovaquone / Proguanil | Radboud University | Phase 4 | 2007-03-01 | 2009-02-24 |
NCT00002340 | Pneumonia, Pneumocystis Carinii|HIV Infections | Drug: Atovaquone|Drug: Pentamidine isethionate | Glaxo Wellcome|NIH AIDS Clinical Trials Information Service | Phase 3 | null | 2005-06-23 |
NCT01479361 | HIV|PCP|Toxoplasmosis | Drug: Atovaquone 750 mg twice daily|Drug: Atovaquone 1500 mg twice daily | National Institutes of Health Clinical Center (CC) | Phase 1 | 2011-10-31 | 2017-01-24 |
NCT00000802 | Pneumonia, Pneumocystis Carinii|HIV Infections | Drug: Atovaquone|Drug: Dapsone | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 3 | null | 2012-04-02 |
NCT00001991 | Pneumonia, Pneumocystis Carinii|HIV Infections | Drug: Atovaquone | Glaxo Wellcome|NIH AIDS Clinical Trials Information Service | null | 2005-06-23 | |
NCT00084227 | Malaria, Falciparum | Drug: Azithromycin/Chloroquine|Drug: Atovaquone/Proguanil | Pfizer | Phase 2|Phase 3 | 2004-07-01 | 2011-05-10 |
NCT00001994 | Toxoplasmosis, Cerebral|HIV Infections | Drug: Atovaquone | Glaxo Wellcome|NIH AIDS Clinical Trials Information Service | null | 2005-06-23 | |
NCT00001990 | Pneumonia, Pneumocystis Carinii|HIV Infections | Drug: Atovaquone | Glaxo Wellcome|NIH AIDS Clinical Trials Information Service | null | 2005-06-23 | |
NCT00001996 | Pneumonia, Pneumocystis Carinii|HIV Infections | Drug: Atovaquone|Drug: Pentamidine isethionate | Glaxo Wellcome|NIH AIDS Clinical Trials Information Service | Phase 2 | null | 2005-06-23 |
NCT00000794 | Toxoplasmosis, Cerebral|HIV Infections | Drug: Sulfadiazine|Drug: Clarithromycin|Drug: Atovaquone|Drug: Pyrimethamine|Drug: Leucovorin calcium | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 2 | null | 2012-04-02 |
NCT00000655 | Pneumonia, Pneumocystis Carinii|HIV Infections | Drug: Atovaquone|Drug: Sulfamethoxazole-Trimethoprim | National Institute of Allergy and Infectious Diseases (NIAID)|Glaxo Wellcome | Phase 2 | null | 2011-02-25 |
NCT00379821 | Plasmodium Falciparum Infection | Drug: Atovaquone-proguanil|Drug: Artesunate|Drug: Azithromycin|Drug: Chloroquine | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 3 | 2007-02-01 | 2014-08-07 |
NCT00000811 | Bacterial Infections|Pneumonia, Pneumocystis Carinii|HIV Infections | Drug: Azithromycin|Drug: Atovaquone|Drug: Sulfamethoxazole-Trimethoprim | National Institute of Allergy and Infectious Diseases (NIAID)|Pfizer|Glaxo Wellcome|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Phase 2 | null | 2012-04-02 |
NCT00444106 | Malaria|Falciparum | Drug: Artesunate-mefloquine|Drug: Atovaquone-proguanil|Drug: Artemether-lumefantrine | Novartis | Phase 4 | 2007-05-01 | 2011-04-01 |
NCT02858817 | Malaria | Drug: atovaquone/proguanil 250mg/100mg (A/P)|Biological: PfSPZ Challenge (NF54)|Other: NaCl 0,9% | University Hospital Tuebingen|Sanaria Inc. | Phase 1 | 2016-10-01 | 2016-08-05 |
NCT01442168 | Malaria, Falciparum | Drug: Sevuparin sodium + atovaquone/proquanil|Drug: atovaquone/proquanil | Dilaforette AB|University of Oxford | Phase 1|Phase 2 | 2011-09-01 | 2014-08-18 |
NCT00386750 | Malaria|Falciparum | Drug: Artemether-lumefantrine | Novartis Pharmaceuticals|Novartis | Phase 4 | 2005-06-01 | 2012-04-25 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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