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Atovaquone

阿托伐醌,Atavaquone,Mepron

Atovaquone用于治疗或预防肺孢子菌肺炎,弓形虫病,疟疾和巴贝西虫。

目录号
EY0668
EY0668
EY0668
EY0668
纯度
99.66%
99.66%
99.66%
99.66%
规格
1 mg
5 mg
10 mg
50 mg
原价
140
298
480
1320
售价
140
298
480
1320
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Atovaquone is a medication used to treat or prevent for pneumocystis pneumonia, toxoplasmosis, malaria, and babesia.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Looareesuwan S, et al. Am J Trop Med Hyg, 1996, 54(1), 62-66.
    [2] El-Sadr, W.M., et al.: N. Engl. J. Med., 339, 1889 (1998)

    分子式
    C22H19ClO3
    分子量
    366.84
    CAS号
    95233-18-4
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    5.1 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02628080 Carcinoma, Non-Small-Cell Lung Drug: Atovaquone University of Oxford Early Phase 1 2016-05-01 2016-06-21
    NCT01858831 Malaria Drug: Atovaquone/proguanil HCL|Drug: Atovaquone GlaxoSmithKline Phase 1 2012-04-01 2017-03-21
    NCT02297477 Malaria Drug: atovaquone-proguanil|Drug: artesunate-atovaquone-proguanil Armed Forces Research Institute of Medical Sciences, Thailand|National Centre for Parasitology, Entomology and Malaria Control, Cambodia|Naval Medical Research Center, Asia (NMRC-A) Phase 4 2014-12-01 2016-01-10
    NCT00000773 Pneumonia, Pneumocystis Carinii|HIV Infections Drug: Atovaquone National Institute of Allergy and Infectious Diseases (NIAID) Phase 1 null 2012-03-30
    NCT00984256 Malaria Drug: Atovaquone Proguanil|Other: Procedure - malaria challenge U.S. Army Medical Research and Materiel Command Phase 2 2009-09-01 2013-10-29
    NCT00421473 HIV Infections|Malaria Drug: Atovaquone / Proguanil Radboud University Phase 4 2007-03-01 2009-02-24
    NCT00002340 Pneumonia, Pneumocystis Carinii|HIV Infections Drug: Atovaquone|Drug: Pentamidine isethionate Glaxo Wellcome|NIH AIDS Clinical Trials Information Service Phase 3 null 2005-06-23
    NCT01479361 HIV|PCP|Toxoplasmosis Drug: Atovaquone 750 mg twice daily|Drug: Atovaquone 1500 mg twice daily National Institutes of Health Clinical Center (CC) Phase 1 2011-10-31 2017-01-24
    NCT00000802 Pneumonia, Pneumocystis Carinii|HIV Infections Drug: Atovaquone|Drug: Dapsone National Institute of Allergy and Infectious Diseases (NIAID) Phase 3 null 2012-04-02
    NCT00001991 Pneumonia, Pneumocystis Carinii|HIV Infections Drug: Atovaquone Glaxo Wellcome|NIH AIDS Clinical Trials Information Service null 2005-06-23
    NCT00084227 Malaria, Falciparum Drug: Azithromycin/Chloroquine|Drug: Atovaquone/Proguanil Pfizer Phase 2|Phase 3 2004-07-01 2011-05-10
    NCT00001994 Toxoplasmosis, Cerebral|HIV Infections Drug: Atovaquone Glaxo Wellcome|NIH AIDS Clinical Trials Information Service null 2005-06-23
    NCT00001990 Pneumonia, Pneumocystis Carinii|HIV Infections Drug: Atovaquone Glaxo Wellcome|NIH AIDS Clinical Trials Information Service null 2005-06-23
    NCT00001996 Pneumonia, Pneumocystis Carinii|HIV Infections Drug: Atovaquone|Drug: Pentamidine isethionate Glaxo Wellcome|NIH AIDS Clinical Trials Information Service Phase 2 null 2005-06-23
    NCT00000794 Toxoplasmosis, Cerebral|HIV Infections Drug: Sulfadiazine|Drug: Clarithromycin|Drug: Atovaquone|Drug: Pyrimethamine|Drug: Leucovorin calcium National Institute of Allergy and Infectious Diseases (NIAID) Phase 2 null 2012-04-02
    NCT00000655 Pneumonia, Pneumocystis Carinii|HIV Infections Drug: Atovaquone|Drug: Sulfamethoxazole-Trimethoprim National Institute of Allergy and Infectious Diseases (NIAID)|Glaxo Wellcome Phase 2 null 2011-02-25
    NCT00379821 Plasmodium Falciparum Infection Drug: Atovaquone-proguanil|Drug: Artesunate|Drug: Azithromycin|Drug: Chloroquine National Institute of Allergy and Infectious Diseases (NIAID) Phase 3 2007-02-01 2014-08-07
    NCT00000811 Bacterial Infections|Pneumonia, Pneumocystis Carinii|HIV Infections Drug: Azithromycin|Drug: Atovaquone|Drug: Sulfamethoxazole-Trimethoprim National Institute of Allergy and Infectious Diseases (NIAID)|Pfizer|Glaxo Wellcome|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Phase 2 null 2012-04-02
    NCT00444106 Malaria|Falciparum Drug: Artesunate-mefloquine|Drug: Atovaquone-proguanil|Drug: Artemether-lumefantrine Novartis Phase 4 2007-05-01 2011-04-01
    NCT02858817 Malaria Drug: atovaquone/proguanil 250mg/100mg (A/P)|Biological: PfSPZ Challenge (NF54)|Other: NaCl 0,9% University Hospital Tuebingen|Sanaria Inc. Phase 1 2016-10-01 2016-08-05
    NCT01442168 Malaria, Falciparum Drug: Sevuparin sodium + atovaquone/proquanil|Drug: atovaquone/proquanil Dilaforette AB|University of Oxford Phase 1|Phase 2 2011-09-01 2014-08-18
    NCT00386750 Malaria|Falciparum Drug: Artemether-lumefantrine Novartis Pharmaceuticals|Novartis Phase 4 2005-06-01 2012-04-25

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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