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Celecoxib

塞来西布,塞来考昔,塞来克西,噻利考西,SC 58635

Celecoxib是环氧合酶-2(COX-2)选择性抑制剂，IC50为40 nM。

目录号
EY0521
EY0521
EY0521
纯度
99.13%
99.13%
99.13%
规格
50 mg
100 mg
500 mg
原价
200
380
580
售价
200
380
580
库存
现货
现货
现货
订购
订购
订购
订购
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  • 生物活性

    In vitro, celecoxib not only reduced the production of PGE2 but also inhibited the downstream effects of PGE2. Celecoxib blocked migration and invasion of A549 cells increased by PGE2 in the wound healing and transwell assays. Additionally, celecoxib reduced MMP9 mRNA expression which was increased by PGE2. Moreover, celecoxib enhanced E-cadherin mRNA expression which was inhibited by PGE2.

  • 体外研究

  • 体内研究

    0.5% methylcellulose+0.2% Tween 80

  • 激酶实验

  • 细胞实验

    0 -75 μM

  • 动物实验

    ≤200 mg/kg 口服处理

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Penning TD, et al. J Med Chem, 1997, 40(9), 1347-1365.
    [2] Silverstein, F.E., et al.: J. Am. Med. Assoc., 284, 1247 (2000)
    [3] Steinbach, G., et al.: N. Engl. J. Med., 342, 1946 (2000)

    分子式
    C17H14F3N3O2S    		 分子量
    381.37    		 CAS号
    169590-42-5    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    76 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    30 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02131012 Inflammation Drug: Intravitreal Celecoxib Vanderbilt University|Pfizer|Vanderbilt University Medical Center Phase 1 2015-06-01 2017-02-20
    NCT01344200 Pharmacokinetics of Celecoxib in Children Drug: Celecoxib Children's Hospital of Eastern Ontario Phase 4 2016-10-01 2016-08-17
    NCT01695226 Breast Neoplasms|Breast Cancer Drug: celecoxib|Drug: Placebo Pierre Hupperets|Maastricht University Medical Center Phase 2 2004-02-01 2012-09-25
    NCT00212108 Nasopharyngeal Carcinoma Drug: celecoxib, gefitinib National University Hospital, Singapore|National Healthcare Group, Singapore Phase 1|Phase 2 2003-11-01 2012-03-29
    NCT02413203 Healthy Drug: Celecoxib|Drug: Placebo University of Pennsylvania|Eli Lilly and Company 2015-03-01 2016-04-21
    NCT02429427 Breast Cancer Drug: Celecoxib|Other: Placebo Imperial College London|Institute of Cancer Research, United Kingdom Phase 3 2005-12-01 2016-08-15
    NCT00583453 Tonsillitis Drug: Celecoxib|Drug: Placebo University of Iowa|Pfizer Phase 2 2007-07-01 2013-12-11
    NCT00030407 Lung Cancer Drug: Celecoxib|Drug: Docetaxel Barbara Ann Karmanos Cancer Institute|National Cancer Institute (NCI) Phase 2 2001-10-01 2013-04-25
    NCT02779166 Hip Labral Tears Drug: Celecoxib|Drug: placebo Northwestern University 2012-08-01 2016-05-19
    NCT03067194 Osteoarthritis Hand Drug: Celecoxib 100 MG|Drug: Celecoxib 200mg Chong Kun Dang Pharmaceutical Phase 4 2016-12-01 2017-02-24
    NCT01503385 Lung Cancer Drug: Celecoxib Chinese Academy of Medical Sciences Phase 2 2011-12-01 2012-01-03
    NCT00849966 Tonsillectomy|Adenotonsillectomy|Pain, Postoperative Drug: Celebrex suspension|Drug: Placebo Children's Hospital of Eastern Ontario|University of Ottawa Phase 2 2009-08-01 2013-04-17
    NCT00030420 Lung Cancer Drug: Celecoxib|Drug: Docetaxel Barbara Ann Karmanos Cancer Institute|National Cancer Institute (NCI) Phase 2 2001-10-01 2013-04-25
    NCT00520338 Postoperative Pain|Thyroidectomy|Cyclooxygenase 2 Inhibitors Drug: celecoxib Mahidol University Phase 4 2007-08-01 2010-11-06
    NCT00447759 Osteoarthritis|Rheumatoid Arthritis Drug: Celecoxib|Drug: non-selective Non steroidal anti inflammatory Drug University of Dundee|University of Glasgow|University of Nottingham Phase 4 2007-06-01 2016-01-07
    NCT00571701 Recurrent Respiratory Papillomatosis Drug: celebrex (celecoxib)|Drug: placebo Northwell Health|National Institute on Deafness and Other Communication Disorders (NIDCD)|University of Iowa|Eastern Virginia Medical School|University of Alabama at Birmingham|University of California, San Francisco|Vanderbilt University|Sanford Health|Weill Medical College of Cornell University Phase 2 2008-02-01 2016-12-29
    NCT00585156 Bone Ingrowth|Pain Drug: Celecoxib University of Utah|Pfizer Early Phase 1 2008-06-01 2016-03-11
    NCT02876094 Spinal Muscular Atrophy (SMA) Drug: celecoxib Hugh McMillan|Families of SMA Canada|Gwendolyn Strong|Children's Hospital of Eastern Ontario Phase 2 2016-09-01 2016-09-16
    NCT01901679 Obesity Drug: Celebrex Rockefeller University Early Phase 1 2013-07-01 2014-11-04
    NCT00087256 Colorectal Cancer Drug: Celecoxib|Other: placebo NSABP Foundation Inc|National Cancer Institute (NCI) Phase 3 2004-07-01 2013-01-04

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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