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Phenformin HCl

盐酸苯乙福明,盐酸苯乙双胍

Phenformin盐酸盐具有抗糖尿病和抗癌活性。

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生物活性

In 5 patients with diabetes mellitus, phenformin reduced the blood glucose values and glycosuria. In 4 of 5 patients, cholesterol and total lipid levels were dropped. Also, Phenformin had no impact on glucose, nor the insulin levels after intravenous glucose loading.
体外研究
体内研究
激酶实验
细胞实验
动物实验
不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数

例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

参考文献

[1] Sakamoto K, et al. Am J Physiol Endocrinol Metab, 2004, 287(2), E310-317.

分子式 C10H16ClN5	分子量 241.72	CAS号 834-28-6	储存方式 ﹣20 ℃冷藏长期储存。冰袋运输
溶剂（常温）	DMSO 50 mg/mL	Water 50 mg/mL	Ethanol 12 mg/mL

体内溶解度

NCT Number	Conditions	Interventions	Sponsor/Collaborators	Phases	Start Date	Last Updated
NCT03026517	Melanoma	Drug: Dabrafenib\|Drug: Trametinib\|Drug: Phenformin	Memorial Sloan Kettering Cancer Center\|Massachusetts General Hospital\|Weill Medical College of Cornell University	Phase 1	2017-01-01	2017-01-18
NCT02476760	Diabetes Mellitus, Type 2	Drug: DPP-4 inhibitors\|Drug: GLP-1 analogs\|Drug: Insulins\|Drug: Biguanides\|Drug: Sulfonylureas\|Drug: Thiazolidinediones\|Drug: Alpha-glucosidase inhibitors\|Drug: Meglitinides	Canadian Network for Observational Drug Effect Studies, CNODES\|Drug Safety and Effectiveness Network, Canada\|Canadian Institutes of Health Research (CIHR)		2014-03-01	2016-11-01
NCT02475499	Diabetes Mellitus, Type 2	Drug: DPP-4 inhibitors\|Drug: GLP-1 analogs\|Drug: Sulfonylureas\|Drug: Biguanides\|Drug: Thiazolidinediones\|Drug: Alpha-glucosidase inhibitors\|Drug: Meglitinides	Canadian Network for Observational Drug Effect Studies, CNODES\|Drug Safety and Effectiveness Network, Canada\|Canadian Institutes of Health Research (CIHR)		2014-03-01	2016-03-11
NCT02456428	Type 2 Diabetes Mellitus	Drug: DPP-4 inhibitors\|Drug: GLP-1 analogs\|Drug: Insulins\|Drug: Biguanides\|Drug: Sulfonylureas\|Drug: Thiazolidinediones\|Drug: Alpha-glucosidase inhibitors\|Drug: Meglitinides	Canadian Network for Observational Drug Effect Studies, CNODES\|Drug Safety and Effectiveness Network, Canada\|Canadian Institutes of Health Research (CIHR)		2014-03-01	2016-04-15

注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。