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Phenformin HCl

盐酸苯乙福明,盐酸苯乙双胍

Phenformin盐酸盐具有抗糖尿病和抗癌活性。

目录号
EY1505
EY1505
EY1505
纯度
99.78%
99.78%
99.78%
规格
50 mg
100 mg
1 g
原价
120
200
480
售价
120
200
480
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    In 5 patients with diabetes mellitus, phenformin reduced the blood glucose values and glycosuria. In 4 of 5 patients, cholesterol and total lipid levels were dropped. Also, Phenformin had no impact on glucose, nor the insulin levels after intravenous glucose loading.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Sakamoto K, et al. Am J Physiol Endocrinol Metab, 2004, 287(2), E310-317.

    分子式
    C10H16ClN5
    分子量
    241.72
    CAS号
    834-28-6
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    50 mg/mL
    Water
    50 mg/mL
    Ethanol
    12 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT03026517 Melanoma Drug: Dabrafenib|Drug: Trametinib|Drug: Phenformin Memorial Sloan Kettering Cancer Center|Massachusetts General Hospital|Weill Medical College of Cornell University Phase 1 2017-01-01 2017-01-18
    NCT02476760 Diabetes Mellitus, Type 2 Drug: DPP-4 inhibitors|Drug: GLP-1 analogs|Drug: Insulins|Drug: Biguanides|Drug: Sulfonylureas|Drug: Thiazolidinediones|Drug: Alpha-glucosidase inhibitors|Drug: Meglitinides Canadian Network for Observational Drug Effect Studies, CNODES|Drug Safety and Effectiveness Network, Canada|Canadian Institutes of Health Research (CIHR) 2014-03-01 2016-11-01
    NCT02475499 Diabetes Mellitus, Type 2 Drug: DPP-4 inhibitors|Drug: GLP-1 analogs|Drug: Sulfonylureas|Drug: Biguanides|Drug: Thiazolidinediones|Drug: Alpha-glucosidase inhibitors|Drug: Meglitinides Canadian Network for Observational Drug Effect Studies, CNODES|Drug Safety and Effectiveness Network, Canada|Canadian Institutes of Health Research (CIHR) 2014-03-01 2016-03-11
    NCT02456428 Type 2 Diabetes Mellitus Drug: DPP-4 inhibitors|Drug: GLP-1 analogs|Drug: Insulins|Drug: Biguanides|Drug: Sulfonylureas|Drug: Thiazolidinediones|Drug: Alpha-glucosidase inhibitors|Drug: Meglitinides Canadian Network for Observational Drug Effect Studies, CNODES|Drug Safety and Effectiveness Network, Canada|Canadian Institutes of Health Research (CIHR) 2014-03-01 2016-04-15

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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