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SCR7

SCR7 is a specific DNA Ligase IV inhibitor (IC50 = 40 nM in Hela and A549 cell).

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生物活性

SCR7 inhibits joining of DSBs in cell-free repair system and NHEJ (nonhomologous end-joining) in a Ligase IV-dependent manner within cells.SCR7 does not induce DSBs directly to the genome and is Ligase IV dependent. Accumulation of DSBs leads to cell death upon SCR7 treatment with a dose-dependent decrease in cell proliferation of MCF7, A549, and HeLa with an IC50 of 40, 34, and 44 μM, respectively, which was further confirmed by DIC imaging in MCF7, T47D, A2780, and HT1080 were also sensitive to SCR7, with an IC50 of 8.5, 120, and 10 μM, respectively. SCR7 treatment (10 mg/kg, six doses) significantly reduced breast adenocarcinoma-induced tumor in mice, whereas treated animals exhibited ～4-fold increase in lifespan.
体外研究
体内研究
激酶实验
细胞实验

250 μM
动物实验

10 mg/kg i.m.
不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数

例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

参考文献

[1] Srivastava M, et al. Cell. 2012, 151(7), 1474-1487.

分子式 C18H14N4OS	分子量 334.4	CAS号 1533426-72-0	储存方式 ﹣20 ℃冷藏长期储存。冰袋运输
溶剂（常温）	DMSO 45 mg/mL	Water <1 mg/mL	Ethanol <1 mg/mL

体内溶解度

Clinical Trial Information ( data from http://clinicaltrials.gov )

注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。
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