Home > Transferase & > Lonafarnib

Lonafarnib

洛那法尼,SCH66336

Lonafarnib(Sch66336)是口服生物相容性的FPTase抑制剂,对H-ras,K-ras-4B和N-ras的IC50分别为1.9 nM,5.2 nM和2.8 nM。

目录号
EY1846
EY1846
EY1846
EY1846
纯度
99.19%
99.19%
99.19%
99.19%
规格
1 mg
5 mg
10 mg
50 mg
原价
430
1080
1720
5520
售价
430
1080
1720
5520
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Lonafarnib (SCH 66336) is a selectively FPTase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM, respectively.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

    0.1 μM - 8 μM

  • 动物实验

    50 mg/kg 口服

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Liu M, et al. Cancer Res, 1998, 58(21), 4947-4956.

    分子式
    C27H31Br2ClN4O2
    分子量
    638.82
    CAS号
    193275-84-2
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    127 mg/mL
    Water
    <1 mg/mL
    Ethanol
    15 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00539968 Prostate Cancer|Breast Cancer|Ovarian Cancer|Lung Cancer|Gastric Cancer Drug: Docetaxel plus lonafarnib Merck Sharp & Dohme Corp. Phase 1|Phase 2 2007-06-01 2015-02-04
    NCT02527707 Chronic Delta Hepatitis Drug: lonafarnib|Drug: Ritonavir Eiger BioPharmaceuticals|Hannover Medical School Phase 2 2015-09-01 2016-09-14
    NCT00109538 Myelodysplastic Syndromes|Leukemia, Myelomonocytic, Chronic|Myelodysplasia|Myelomonocytic Drug: Lonafarnib|Other: Placebo Merck Sharp & Dohme Corp. Phase 3 2005-05-01 2015-04-09
    NCT00773474 Metastatic Breast Cancer Drug: Lonafarnib George Sledge|Schering-Plough|Hoosier Cancer Research Network Phase 2 2008-10-01 2016-01-21
    NCT00081510 Breast Cancer Drug: Lonafarnib|Drug: Placebo|Drug: anastrozole Merck Sharp & Dohme Corp. Phase 2 2003-12-01 2015-03-26
    NCT00047502 Chronic Myelogenous Leukemia Drug: Lonafarnib (SCH66336)|Drug: Imatinib Mesylate (Gleevec) M.D. Anderson Cancer Center Phase 1 2002-11-01 2012-02-20
    NCT01495585 Hepatitis D Drug: Lonafarnib|Other: Placebo National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|National Institutes of Health Clinical Center (CC) Phase 2 2011-12-01 2016-07-18
    NCT02430194 Chronic Hepatitis D Infection Drug: lonafarnib|Drug: Ritonavir|Drug: PEG IFN-a Eiger BioPharmaceuticals|Ankara University Phase 2 2014-12-01 2017-02-26
    NCT02430181 Chronic Hepatitis D Infection Drug: lonafarnib|Drug: PEG IFN-a|Drug: Ritonavir Eiger BioPharmaceuticals Phase 2 2014-11-01 2017-01-18
    NCT00103090 Head and Neck Cancer Drug: Fenretinide|Drug: Lonafarnib M.D. Anderson Cancer Center|National Cancer Institute (NCI) Phase 1 2005-01-01 2012-11-12
    NCT00288444 Lung Cancer|Soft Tissue Sarcoma|Colorectal Carcinoma|Breast Cancer|Prostate Cancer Drug: Lonafarnib|Drug: Docetaxel Emory University|Aventis Pharmaceuticals|Schering-Plough Phase 1 2006-01-01 2012-12-17
    NCT00102648 Glioblastoma Multiforme|Gliosarcoma|Brain Tumors Drug: Sarasar|Drug: Temodar M.D. Anderson Cancer Center|Schering-Plough Phase 1 2004-12-01 2016-06-07
    NCT00015899 Brain and Central Nervous System Tumors Drug: lonafarnib Pediatric Brain Tumor Consortium|National Cancer Institute (NCI) Phase 1 2002-01-01 2009-10-13
    NCT02968641 Chronic Delta Hepatitis Drug: Lonafarnib|Drug: Ritonavir Eiger BioPharmaceuticals Phase 2 2017-03-01 2016-11-16
    NCT01232881 Breast Cancer Procedure: Tumor Sample|Procedure: Serum Sample Hoosier Cancer Research Network|United States Department of Defense|Indiana University School of Medicine|Emory University 2009-08-01 2011-04-27
    NCT00281515 Epithelial Ovarian Cancer Drug: Lonafarnib AGO Study Group Phase 2 2006-01-01 2012-06-28
    NCT00083096 Brain and Central Nervous System Tumors Drug: lonafarnib|Drug: temozolomide European Organisation for Research and Treatment of Cancer - EORTC Phase 1 2004-03-01 2015-02-09
    NCT02511431 Hepatitis D Drug: Lonafarnib|Drug: Ritonavir|Other: Placebo National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|National Institutes of Health Clinical Center (CC) Phase 2 2015-07-21 2017-03-10

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

  • 相关化合物库

  • 使用AMQUAR产品发表文献后请联系我们

相关推荐

X
  • 联系人 :
  • 收件地址 :
  • 电话号码 :
  • 单位名称 :
  • 产品货号 :
  • 产品规格 :
  • 发票抬头以及单位税号 :