Chloroquine Phosphate是一种4-氨基喹啉的抗疟疾和抗风湿抑制剂。
Chloroquine diphosphate has been reported as an adjuvant for radiation and chemotherapy for inducing cell autophagy to anti-cancer cells proliferation or metastasis. The mechanism of chloroquine diphosphate inducing cells autophagy is arresting cells in G1, up-regulates the expression of p27 and p53 while down-regulates the expression of CDK2 and cyclin D1.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Slater AF. Pharmacol Ther, 1993, 57(2-3), 203-235.
[2] Savarino A, et al. Lancet Infect Dis, 2003, 3(11), 722-727.
[3] Weber SM, et al. Curr Opin Microbiol, 2000, 3(4), 349-353.
分子式 C18H26ClN3.2H3O4P |
分子量 515.86 |
CAS号 50-63-5 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO <1 mg/mL |
Water 100 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT00969306 | Small Cell Lung Cancer | Drug: Chloroquine, A-CQ 100 | Maastricht Radiation Oncology|Maastricht University Medical Center|National Cancer Institute (NCI) | Phase 1 | 2013-09-01 | 2016-09-27 |
NCT01575782 | Small Cell Lung Cancer | Drug: Chloroquine | Maastricht Radiation Oncology | Phase 1 | 2014-05-01 | 2016-09-27 |
NCT01546961 | Vivax Malaria | Drug: Chloroquine | University of Oxford | 2011-06-01 | 2017-01-04 | |
NCT02496741 | Glioma|Cholangiocarcinoma|Chondrosarcoma | Drug: Metformin and chloroquine combination | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Phase 1|Phase 2 | 2015-11-01 | 2015-11-14 |
NCT02932007 | Atrial Fibrillation | Drug: Chloroquine Phosphate | University of South Florida | Phase 2 | 2017-01-01 | 2017-01-17 |
NCT02698748 | Malaria | Drug: Chloroquine|Drug: Placebo | Centro de Investigacao em Saude de Manhica | Phase 2|Phase 3 | 2015-01-01 | 2016-02-29 |
NCT01980745 | Hepatitis, Autoimmune | Drug: Chloroquine diphosphate 250mg|Drug: Placebo | University of Sao Paulo General Hospital | Phase 4 | 2002-02-01 | 2016-10-25 |
NCT00308620 | HIV Infections | Drug: chloroquine phosphate|Drug: Placebo | University of Minnesota - Clinical and Translational Science Institute|Minnesota Medical Foundation | Phase 2|Phase 3 | 2006-03-01 | 2012-07-09 |
NCT01023477 | Carcinoma, Intraductal, Noninfiltrating|DCIS|Ductal Carcinoma In Situ | Drug: Chloroquine Standard Dose (500mg/week)|Drug: Chloroquine Low Dose (250mg/week)|Procedure: Breast Biopsy | Inova Health Care Services|George Mason University|University of Pittsburgh|United States Department of Defense|U.S. Army Medical Research and Materiel Command | Phase 1|Phase 2 | 2009-12-01 | 2017-03-07 |
NCT01078779 | Influenza | Drug: Chloroquine|Drug: Placebo | National University Hospital, Singapore | Phase 2 | 2009-11-01 | 2010-02-28 |
NCT02463331 | Autoimmune Hepatitis | Drug: Chloroquine diphosphate|Drug: prednisone|Drug: azathioprine | University of Sao Paulo General Hospital | Phase 4 | 2003-05-01 | 2016-12-29 |
NCT02610686 | Plasmodium Vivax | Drug: Chloroquine | National Institute of Malariology, Parasitology and Entomology, Vietnam|Institute of Tropical Medicine, Belgium | Phase 4 | 2015-03-01 | 2016-03-22 |
NCT02004314 | HIV | Drug: Chloroquine | CIHR Canadian HIV Trials Network | 2009-10-01 | 2013-12-03 | |
NCT01894633 | Brain Metastasis | Drug: Chloroquine|Radiation: Total brain radiotherapy | Instituto Nacional de Cancerologia de Mexico | Phase 2 | 2011-05-01 | 2017-03-02 |
NCT02071537 | Malignant Neoplasm|Solid Tumors | Drug: Chloroquine|Drug: Carboplatin|Drug: Gemcitabine | University of Cincinnati | Phase 1 | 2014-05-01 | 2017-01-05 |
NCT01814423 | Malaria | Drug: Chloroquine-base 50 mg|Drug: Chloroquine-base 70 mg | Bandim Health Project | Phase 4 | 2013-04-01 | 2014-03-10 |
NCT02691910 | Malaria, Vivax | Drug: Chloroquine|Drug: Primaquine | Oswaldo Cruz Foundation|University of Sao Paulo | Phase 2|Phase 3 | 2014-08-01 | 2016-02-24 |
NCT00844207 | Malaria | Drug: Fixed combination of Azithromycin and Chloroquine|Drug: Azithromycin and Chloroquine | Pfizer | Phase 1 | 2009-02-01 | 2009-04-20 |
NCT00473837 | Malaria Anaemia | Drug: Chloroquine|Drug: Placebo | Medical Research Council Unit, The Gambia | 2007-07-01 | 2014-10-09 | |
NCT01777477 | Pancreatic Cancer | Drug: Chloroquine|Drug: Gemcitabine | University of Zurich | Phase 1 | 2012-07-01 | 2015-09-21 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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