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Chloroquine Phosphate

磷酸氯喹,Resochin bisphosphate,Aralen diphosphate

Chloroquine Phosphate是一种4-氨基喹啉的抗疟疾和抗风湿抑制剂。

目录号
EY1843
EY1843
EY1843
纯度
99.52%
99.52%
99.52%
规格
50 mg
100 mg
500 mg
原价
260
400
1500
售价
260
400
1500
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Chloroquine diphosphate has been reported as an adjuvant for radiation and chemotherapy for inducing cell autophagy to anti-cancer cells proliferation or metastasis. The mechanism of chloroquine diphosphate inducing cells autophagy is arresting cells in G1, up-regulates the expression of p27 and p53 while down-regulates the expression of CDK2 and cyclin D1.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Slater AF. Pharmacol Ther, 1993, 57(2-3), 203-235.
    [2] Savarino A, et al. Lancet Infect Dis, 2003, 3(11), 722-727.
    [3] Weber SM, et al. Curr Opin Microbiol, 2000, 3(4), 349-353.

    分子式
    C18H26ClN3.2H3O4P
    分子量
    515.86
    CAS号
    50-63-5
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    <1 mg/mL
    Water
    100 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00969306 Small Cell Lung Cancer Drug: Chloroquine, A-CQ 100 Maastricht Radiation Oncology|Maastricht University Medical Center|National Cancer Institute (NCI) Phase 1 2013-09-01 2016-09-27
    NCT01575782 Small Cell Lung Cancer Drug: Chloroquine Maastricht Radiation Oncology Phase 1 2014-05-01 2016-09-27
    NCT01546961 Vivax Malaria Drug: Chloroquine University of Oxford 2011-06-01 2017-01-04
    NCT02496741 Glioma|Cholangiocarcinoma|Chondrosarcoma Drug: Metformin and chloroquine combination Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Phase 1|Phase 2 2015-11-01 2015-11-14
    NCT02932007 Atrial Fibrillation Drug: Chloroquine Phosphate University of South Florida Phase 2 2017-01-01 2017-01-17
    NCT02698748 Malaria Drug: Chloroquine|Drug: Placebo Centro de Investigacao em Saude de Manhica Phase 2|Phase 3 2015-01-01 2016-02-29
    NCT01980745 Hepatitis, Autoimmune Drug: Chloroquine diphosphate 250mg|Drug: Placebo University of Sao Paulo General Hospital Phase 4 2002-02-01 2016-10-25
    NCT00308620 HIV Infections Drug: chloroquine phosphate|Drug: Placebo University of Minnesota - Clinical and Translational Science Institute|Minnesota Medical Foundation Phase 2|Phase 3 2006-03-01 2012-07-09
    NCT01023477 Carcinoma, Intraductal, Noninfiltrating|DCIS|Ductal Carcinoma In Situ Drug: Chloroquine Standard Dose (500mg/week)|Drug: Chloroquine Low Dose (250mg/week)|Procedure: Breast Biopsy Inova Health Care Services|George Mason University|University of Pittsburgh|United States Department of Defense|U.S. Army Medical Research and Materiel Command Phase 1|Phase 2 2009-12-01 2017-03-07
    NCT01078779 Influenza Drug: Chloroquine|Drug: Placebo National University Hospital, Singapore Phase 2 2009-11-01 2010-02-28
    NCT02463331 Autoimmune Hepatitis Drug: Chloroquine diphosphate|Drug: prednisone|Drug: azathioprine University of Sao Paulo General Hospital Phase 4 2003-05-01 2016-12-29
    NCT02610686 Plasmodium Vivax Drug: Chloroquine National Institute of Malariology, Parasitology and Entomology, Vietnam|Institute of Tropical Medicine, Belgium Phase 4 2015-03-01 2016-03-22
    NCT02004314 HIV Drug: Chloroquine CIHR Canadian HIV Trials Network 2009-10-01 2013-12-03
    NCT01894633 Brain Metastasis Drug: Chloroquine|Radiation: Total brain radiotherapy Instituto Nacional de Cancerologia de Mexico Phase 2 2011-05-01 2017-03-02
    NCT02071537 Malignant Neoplasm|Solid Tumors Drug: Chloroquine|Drug: Carboplatin|Drug: Gemcitabine University of Cincinnati Phase 1 2014-05-01 2017-01-05
    NCT01814423 Malaria Drug: Chloroquine-base 50 mg|Drug: Chloroquine-base 70 mg Bandim Health Project Phase 4 2013-04-01 2014-03-10
    NCT02691910 Malaria, Vivax Drug: Chloroquine|Drug: Primaquine Oswaldo Cruz Foundation|University of Sao Paulo Phase 2|Phase 3 2014-08-01 2016-02-24
    NCT00844207 Malaria Drug: Fixed combination of Azithromycin and Chloroquine|Drug: Azithromycin and Chloroquine Pfizer Phase 1 2009-02-01 2009-04-20
    NCT00473837 Malaria Anaemia Drug: Chloroquine|Drug: Placebo Medical Research Council Unit, The Gambia 2007-07-01 2014-10-09
    NCT01777477 Pancreatic Cancer Drug: Chloroquine|Drug: Gemcitabine University of Zurich Phase 1 2012-07-01 2015-09-21

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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