Betamethasone

倍他米松,贝他美松,NSC-39470,SCH-4831,Celestone,NSC39470,SCH 4831,NSC 39470,SCH4831

Betamethasone为糖皮质素类固醇,具有抗炎和免疫抑制活性。

目录号
EY1824
EY1824
EY1824
纯度
99.47%
99.47%
99.47%
规格
50 mg
100 mg
500 mg
原价
500
750
3360
售价
500
750
3360
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Betamethasone is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Schwab M, et al. J Physiol,2000, 528(Pt 3), 619-632.
    [2] Hofmann TG, Hehner SP, Bacher S et al. FEBS Lett. 441:441-6 (1998).
    [3] Kalthoff FS, Chung J, Musser P et al. Clin Exp Immunol. 133:350-9 (2003).

    分子式
    C22H29FO5
    分子量
    392.46
    CAS号
    378-44-9
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    79 mg/mL
    Water
    Insoluble
    Ethanol
    10 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00139256 Respiratory Distress Syndrome, Newborn Drug: Betamethasone Emory University Phase 2|Phase 3 2005-08-01 2013-11-25
    NCT00963573 Rhinitis Drug: Loratadine|Drug: Betamethasone Merck Sharp & Dohme Corp. Phase 4 2003-09-01 2015-04-20
    NCT01885481 Back Pain|Neck Pain Drug: Dexamethasone|Drug: Betamethasone Seoul National University Bundang Hospital 2013-10-01 2016-03-28
    NCT03026478 Oral Lichen Planus Drug: Betamethasone Dipropionate|Drug: Clobetasol Propionate Garlapati Komali|Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre Phase 2 2016-05-01 2017-01-21
    NCT01011621 Dermatitis, Atopic|Dermatitis, Contact|Dermatitis, Seborrheic|Psoriasis Drug: 0.5% prednisolone acetate cream|Drug: 0.1% betamethasone valerate cream Mantecorp Industria Quimica e Farmaceutica Ltd. Phase 3 2010-02-01 2009-11-10
    NCT02114073 Glaucoma, Open Angle Drug: Cyclosporine|Drug: Betamethasone Mashhad University of Medical Sciences Phase 2 2014-04-01 2015-04-17
    NCT02897076 Neonatal Complications Drug: betamethasone 24 mg|Drug: 12mg betamethasone +placebo Assistance Publique - H么pitaux de Paris Phase 3 2017-01-01 2017-01-13
    NCT02939742 PPROM|Respiratory Distress Syndrome in Premature Infants Drug: Betamethasone|Drug: Placebo The University of Texas Medical Branch, Galveston Phase 2|Phase 3 2016-11-01 2016-10-17
    NCT00453141 Preterm Delivery Drug: dosing of Betamethasone The Cooper Health System 2006-04-01 2009-11-07
    NCT00608673 Discoid Lupus Erythematosus Drug: Pimecrolimus 1% cream|Drug: betamethasone valerate 0.1% cream Shahid Beheshti University of Medical Sciences 2006-04-01 2008-02-06
    NCT02833116 Chronic Pain Drug: Betamethasone|Drug: Dexamethasone Basque Health Service Phase 4 2016-06-01 2016-10-24
    NCT00279162 Psoriasis Drug: Calcipotriene/betamethasone gel and ointment LEO Pharma Phase 3 2005-12-01 2015-03-25
    NCT01165775 Pregnancy Complications Device: Dexcom Seven Plus Continuous Glucose Monitoring System Stanford University 2010-07-01 2016-07-28
    NCT02191007 Psoriasis Drug: Calcipotriol Betamethasone ointment and Calcipotriol ointment|Drug: Calcipotriol Betamethasone ointment|Drug: Calcipotriol Betamethasone ointment and Urea Cream Xijing Hospital 2013-11-01 2014-07-11
    NCT00574249 Chronic Plaque Psoriasis Biological: adalimumab|Drug: Calcipotriol/Betamethasone Ointment|Drug: placebo (vehicle ointment) Abbott Phase 3 2007-11-01 2011-04-11
    NCT00800293 Healthy Drug: Betamethasone Dipropionate 0.05% Cream Perrigo Company Phase 1 2002-12-01 2012-03-15
    NCT02004574 Psoriasis Vulgaris Drug: Calcipotriol/betamethasone dipropionate gel Jooheung Lee|Samsung Medical Center Phase 4 2013-10-01 2014-06-03
    NCT02582177 Tinea Drug: Ketoconazole + betamethasone dipropionate|Drug: Clotrimazole + Dexamethasone acetate Ache Laboratorios Farmaceuticos S.A. Phase 3 2017-08-01 2017-02-14

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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