Betamethasone为糖皮质素类固醇,具有抗炎和免疫抑制活性。
Betamethasone is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Schwab M, et al. J Physiol,2000, 528(Pt 3), 619-632.
[2] Hofmann TG, Hehner SP, Bacher S et al. FEBS Lett. 441:441-6 (1998).
[3] Kalthoff FS, Chung J, Musser P et al. Clin Exp Immunol. 133:350-9 (2003).
分子式 C22H29FO5 |
分子量 392.46 |
CAS号 378-44-9 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 79 mg/mL |
Water Insoluble |
Ethanol 10 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT00139256 | Respiratory Distress Syndrome, Newborn | Drug: Betamethasone | Emory University | Phase 2|Phase 3 | 2005-08-01 | 2013-11-25 |
NCT00963573 | Rhinitis | Drug: Loratadine|Drug: Betamethasone | Merck Sharp & Dohme Corp. | Phase 4 | 2003-09-01 | 2015-04-20 |
NCT01885481 | Back Pain|Neck Pain | Drug: Dexamethasone|Drug: Betamethasone | Seoul National University Bundang Hospital | 2013-10-01 | 2016-03-28 | |
NCT03026478 | Oral Lichen Planus | Drug: Betamethasone Dipropionate|Drug: Clobetasol Propionate | Garlapati Komali|Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre | Phase 2 | 2016-05-01 | 2017-01-21 |
NCT01011621 | Dermatitis, Atopic|Dermatitis, Contact|Dermatitis, Seborrheic|Psoriasis | Drug: 0.5% prednisolone acetate cream|Drug: 0.1% betamethasone valerate cream | Mantecorp Industria Quimica e Farmaceutica Ltd. | Phase 3 | 2010-02-01 | 2009-11-10 |
NCT02114073 | Glaucoma, Open Angle | Drug: Cyclosporine|Drug: Betamethasone | Mashhad University of Medical Sciences | Phase 2 | 2014-04-01 | 2015-04-17 |
NCT02897076 | Neonatal Complications | Drug: betamethasone 24 mg|Drug: 12mg betamethasone +placebo | Assistance Publique - H么pitaux de Paris | Phase 3 | 2017-01-01 | 2017-01-13 |
NCT02939742 | PPROM|Respiratory Distress Syndrome in Premature Infants | Drug: Betamethasone|Drug: Placebo | The University of Texas Medical Branch, Galveston | Phase 2|Phase 3 | 2016-11-01 | 2016-10-17 |
NCT00453141 | Preterm Delivery | Drug: dosing of Betamethasone | The Cooper Health System | 2006-04-01 | 2009-11-07 | |
NCT00608673 | Discoid Lupus Erythematosus | Drug: Pimecrolimus 1% cream|Drug: betamethasone valerate 0.1% cream | Shahid Beheshti University of Medical Sciences | 2006-04-01 | 2008-02-06 | |
NCT02833116 | Chronic Pain | Drug: Betamethasone|Drug: Dexamethasone | Basque Health Service | Phase 4 | 2016-06-01 | 2016-10-24 |
NCT00279162 | Psoriasis | Drug: Calcipotriene/betamethasone gel and ointment | LEO Pharma | Phase 3 | 2005-12-01 | 2015-03-25 |
NCT01165775 | Pregnancy Complications | Device: Dexcom Seven Plus Continuous Glucose Monitoring System | Stanford University | 2010-07-01 | 2016-07-28 | |
NCT02191007 | Psoriasis | Drug: Calcipotriol Betamethasone ointment and Calcipotriol ointment|Drug: Calcipotriol Betamethasone ointment|Drug: Calcipotriol Betamethasone ointment and Urea Cream | Xijing Hospital | 2013-11-01 | 2014-07-11 | |
NCT00574249 | Chronic Plaque Psoriasis | Biological: adalimumab|Drug: Calcipotriol/Betamethasone Ointment|Drug: placebo (vehicle ointment) | Abbott | Phase 3 | 2007-11-01 | 2011-04-11 |
NCT00800293 | Healthy | Drug: Betamethasone Dipropionate 0.05% Cream | Perrigo Company | Phase 1 | 2002-12-01 | 2012-03-15 |
NCT02004574 | Psoriasis Vulgaris | Drug: Calcipotriol/betamethasone dipropionate gel | Jooheung Lee|Samsung Medical Center | Phase 4 | 2013-10-01 | 2014-06-03 |
NCT02582177 | Tinea | Drug: Ketoconazole + betamethasone dipropionate|Drug: Clotrimazole + Dexamethasone acetate | Ache Laboratorios Farmaceuticos S.A. | Phase 3 | 2017-08-01 | 2017-02-14 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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