Melatonin

褪黑素,褪黑激素,松果体素,松果素,美拉托宁,美乐托宁,MLT,Melovine

Melatonin是由松果体产生的激素。

目录号
EY1809
EY1809
EY1809
EY1809
纯度
99.46%
99.46%
99.46%
99.46%
规格
100 mg
500 mg
1 g
5 g
原价
150
300
480
990
售价
150
300
480
990
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Melatonin is a MT receptor agonist, used as a dietary supplement.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Reiter RJ, et al. J Biomed Sci, 2000, 7(6), 444-458.
    [2] Dubocovich, M.L., et al. 1998. FASEB J. 12: 1211-1220.
    [3] Hardeland, R. 2005. Endocrine. 27: 119-130.
    [4] Boutin, J.A., et al. 2005. Trends Pharmacol. Sci. 26: 412-419.

    分子式
    C13H16N2O2
    分子量
    232.28
    CAS号
    73-31-4
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    50 mM
    Water
    <1 mg/mL
    Ethanol

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02845778 Pharmacokinetics of Melatonin Drug: Melatonin Khon Kaen University Phase 1|Phase 2 2016-05-01 2016-07-24
    NCT02107079 Pharmacokinetics of Melatonin Drug: Melatonin Utrecht University 2012-01-01 2014-04-03
    NCT00790478 Ulcerative Colitis Dietary Supplement: Melatonin|Other: Placebo Emory University Phase 2 2009-01-01 2009-12-22
    NCT02644590 Diabetes Mellitus, Type 1|Hypertension Drug: Melatonin Sheba Medical Center Early Phase 1 2016-02-01 2015-12-30
    NCT01805089 Breast Cancer Drug: Melatonin 3 mg Dana-Farber Cancer Institute Early Phase 1 2006-10-01 2015-03-03
    NCT01858155 Relapsed Malignant Solid Tumor Drug: Melatonin C17 Council Phase 1 2013-05-01 2017-01-30
    NCT01705639 Diabetes|Glucose Tolerance Drug: Melatonin Helsinki University|Lund University|Folkhalsan Research Center Phase 3 2012-11-01 2017-01-03
    NCT00849511 Migraine Drug: melatonin Nordlandssykehuset HF|University of Tromso Phase 2 2009-02-01 2014-09-24
    NCT00927030 Autistic Disorder|Insomnia Drug: supplemental liquid melatonin|Drug: flavored liquid or liquid supplemental melatonin Vanderbilt University|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Phase 1 2008-01-01 2012-06-28
    NCT00686907 Blindness Drug: Melatonin National Eye Institute (NEI) 2007-03-01 2012-10-23
    NCT01370486 Lennox-Gastaut Syndrome Drug: melatonin|Drug: placebo Institution de Lavigny Phase 4 2011-08-01 2011-06-09
    NCT02963181 Hypotension, Orthostatic|Hypertension|Autonomic Nervous System Diseases Drug: Yohimbine|Drug: Melatonin Lawson Health Research Institute Early Phase 1 2017-01-01 2016-11-14
    NCT01860716 Evidence of Liver Transplantation Drug: Melatonin|Drug: Placebo Aragon Institute of Health Sciences|Fondo de Investigacion Sanitaria Phase 3 2013-05-01 2013-05-22
    NCT02359448 Parkinson's Disease|Nocturia Drug: Melatonin University College, London Phase 2 2015-04-01 2015-02-04
    NCT02768077 Parkinson's Disease Drug: Melatonin(Circadin庐)|Drug: Placebo Kuhnil Pharmaceutical Co., Ltd. Phase 4 2016-01-01 2016-05-16
    NCT01695070 Fetal Growth Retardation Drug: Melatonin Monash University Phase 4 2012-09-01 2014-11-14
    NCT01700959 Cancer Malignancies Drug: melatonin|Drug: placebo St. Jude Children's Research Hospital|National Cancer Institute (NCI) Phase 3 2013-01-01 2016-12-20
    NCT03013790 Delirium|Melatonin Drug: Melatonin MICE Trial Group Phase 4 2016-12-01 2017-01-04
    NCT02836743 REM Sleep Behavior Disorder Drug: Circadin|Drug: Placebo Seoul National University Hospital Phase 4 2016-01-01 2016-07-18
    NCT02536417 Delirium Drug: Melatonin|Drug: Sugar pill Fraser Health Phase 3 2015-09-01 2015-08-27
    NCT02454855 Cancer Drug: melatonin|Drug: placebo Centre Jean Perrin Phase 3 2015-05-01 2016-06-10

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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