Melatonin是由松果体产生的激素。
Melatonin is a MT receptor agonist, used as a dietary supplement.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Reiter RJ, et al. J Biomed Sci, 2000, 7(6), 444-458.
[2] Dubocovich, M.L., et al. 1998. FASEB J. 12: 1211-1220.
[3] Hardeland, R. 2005. Endocrine. 27: 119-130.
[4] Boutin, J.A., et al. 2005. Trends Pharmacol. Sci. 26: 412-419.
分子式 C13H16N2O2 |
分子量 232.28 |
CAS号 73-31-4 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 50 mM |
Water <1 mg/mL |
Ethanol |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02845778 | Pharmacokinetics of Melatonin | Drug: Melatonin | Khon Kaen University | Phase 1|Phase 2 | 2016-05-01 | 2016-07-24 |
NCT02107079 | Pharmacokinetics of Melatonin | Drug: Melatonin | Utrecht University | 2012-01-01 | 2014-04-03 | |
NCT00790478 | Ulcerative Colitis | Dietary Supplement: Melatonin|Other: Placebo | Emory University | Phase 2 | 2009-01-01 | 2009-12-22 |
NCT02644590 | Diabetes Mellitus, Type 1|Hypertension | Drug: Melatonin | Sheba Medical Center | Early Phase 1 | 2016-02-01 | 2015-12-30 |
NCT01805089 | Breast Cancer | Drug: Melatonin 3 mg | Dana-Farber Cancer Institute | Early Phase 1 | 2006-10-01 | 2015-03-03 |
NCT01858155 | Relapsed Malignant Solid Tumor | Drug: Melatonin | C17 Council | Phase 1 | 2013-05-01 | 2017-01-30 |
NCT01705639 | Diabetes|Glucose Tolerance | Drug: Melatonin | Helsinki University|Lund University|Folkhalsan Research Center | Phase 3 | 2012-11-01 | 2017-01-03 |
NCT00849511 | Migraine | Drug: melatonin | Nordlandssykehuset HF|University of Tromso | Phase 2 | 2009-02-01 | 2014-09-24 |
NCT00927030 | Autistic Disorder|Insomnia | Drug: supplemental liquid melatonin|Drug: flavored liquid or liquid supplemental melatonin | Vanderbilt University|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Phase 1 | 2008-01-01 | 2012-06-28 |
NCT00686907 | Blindness | Drug: Melatonin | National Eye Institute (NEI) | 2007-03-01 | 2012-10-23 | |
NCT01370486 | Lennox-Gastaut Syndrome | Drug: melatonin|Drug: placebo | Institution de Lavigny | Phase 4 | 2011-08-01 | 2011-06-09 |
NCT02963181 | Hypotension, Orthostatic|Hypertension|Autonomic Nervous System Diseases | Drug: Yohimbine|Drug: Melatonin | Lawson Health Research Institute | Early Phase 1 | 2017-01-01 | 2016-11-14 |
NCT01860716 | Evidence of Liver Transplantation | Drug: Melatonin|Drug: Placebo | Aragon Institute of Health Sciences|Fondo de Investigacion Sanitaria | Phase 3 | 2013-05-01 | 2013-05-22 |
NCT02359448 | Parkinson's Disease|Nocturia | Drug: Melatonin | University College, London | Phase 2 | 2015-04-01 | 2015-02-04 |
NCT02768077 | Parkinson's Disease | Drug: Melatonin(Circadin庐)|Drug: Placebo | Kuhnil Pharmaceutical Co., Ltd. | Phase 4 | 2016-01-01 | 2016-05-16 |
NCT01695070 | Fetal Growth Retardation | Drug: Melatonin | Monash University | Phase 4 | 2012-09-01 | 2014-11-14 |
NCT01700959 | Cancer Malignancies | Drug: melatonin|Drug: placebo | St. Jude Children's Research Hospital|National Cancer Institute (NCI) | Phase 3 | 2013-01-01 | 2016-12-20 |
NCT03013790 | Delirium|Melatonin | Drug: Melatonin | MICE Trial Group | Phase 4 | 2016-12-01 | 2017-01-04 |
NCT02836743 | REM Sleep Behavior Disorder | Drug: Circadin|Drug: Placebo | Seoul National University Hospital | Phase 4 | 2016-01-01 | 2016-07-18 |
NCT02536417 | Delirium | Drug: Melatonin|Drug: Sugar pill | Fraser Health | Phase 3 | 2015-09-01 | 2015-08-27 |
NCT02454855 | Cancer | Drug: melatonin|Drug: placebo | Centre Jean Perrin | Phase 3 | 2015-05-01 | 2016-06-10 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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