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Itraconazole

伊曲康唑,R 51211,Oriconazole,Sporanox

Itraconazole 是一种三唑类抗真菌药物。

目录号
EY1788
EY1788
纯度
99.31%
99.31%
规格
100 mg
500 mg
原价
498
1920
售价
498
1920
库存
现货
现货
订购
订购
订购
订购
订购
订购
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  • 生物活性

    Itraconazole is a triazole antifungal agent.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Isoherranen N, et al. Drug Metab Dispos, 2004, 32(10), 1121-1131.
    [2] Chong et al (2007) Inhibition of angiogenesis by the antifungal drug itraconazole. ACS Chem.Biol. 2 263.
    [3] Pace et al (2016) Repurposing the clinically efficacious antifungal agent itraconazole as an anticancer chemotherapeutic. J.Med.Chem. 59 3635.
    [4] Kim et al (2013) Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists. Cancer Cell 23 23.

    分子式
    C35H38Cl2N8O4    		 分子量
    705.63    		 CAS号
    84625-61-6    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    5 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00588016 Sinusitis Drug: Itraconazole Mayo Clinic Phase 1 2007-04-01 2015-04-12
    NCT01108094 Skin Cancers|Carcinoma, Basal Cell|Skin Cancer|Basal Cell Carcinoma Drug: Itraconazole Stanford University Phase 2 2010-04-01 2016-06-30
    NCT01021683 Hematologic Neoplasms|Neutropenia|Fever Drug: Itraconazole Janssen Korea, Ltd., Korea Phase 4 2009-07-01 2013-07-24
    NCT00769600 Recurrent Non Small Cell Lung Cancer Drug: Itraconazole|Drug: Pemetrexed Sidney Kimmel Comprehensive Cancer Center Phase 2 2008-11-01 2016-10-12
    NCT01409018 Pediatric, Cancer Drug: Itraconazole Seoul National University Hospital Phase 1 2009-06-01 2013-11-17
    NCT00798135 Breast Neoplasms|Neoplasm Metastasis Drug: itraconazole Indiana University 2008-11-01 2015-08-28
    NCT01706562 Neutropenia Drug: Itraconazole Janssen Korea, Ltd., Korea Phase 4 2011-05-01 2013-02-18
    NCT00871728 Onychomycosis, Toe Drug: Itraconazole Janssen Korea, Ltd., Korea Phase 4 2007-01-01 2013-06-24
    NCT02120677 Basal Cell Carcinoma Drug: Itraconazole Johns Hopkins University Early Phase 1 2014-05-01 2016-09-21
    NCT00356915 Onychomycosis Drug: Itraconazole 100mg capsules|Drug: Itraconazole 200mg tablets|Drug: Placebo tablets Stiefel, a GSK Company|GlaxoSmithKline Phase 3 2006-07-01 2016-12-16
    NCT02259010 Advanced Solid Tumors|Relapsed/Refractory Lymphoma Drug: Alisertib|Drug: Itraconazole Millennium Pharmaceuticals, Inc. Phase 1 2014-10-01 2016-01-06
    NCT01787331 Prostate Cancer Drug: Itraconazole University of California, San Francisco Phase 2 2013-11-01 2016-10-24
    NCT01823289 Pulmonary Fungal Infection Drug: Itraconazole Xian-Janssen Pharmaceutical Ltd. Phase 4 2007-06-01 2013-04-12
    NCT03086226 Mycetoma Drug: Fosravuconazole|Drug: Itraconazole Drugs for Neglected Diseases Phase 2 2017-03-31 2017-03-15
    NCT00887458 Prostate Cancer Drug: Itraconazole 200 mg|Drug: Itraconazole 300mg Johns Hopkins University|Memorial Sloan Kettering Cancer Center Phase 2 2009-07-01 2014-01-28
    NCT02455856 Healthy Drug: JNJ-42847922|Drug: Itraconazole Janssen Cilag N.V./S.A. Phase 1 2015-05-01 2015-07-24
    NCT02175407 Pharmacokinetics|DDI (Drug-Drug Interaction)|Healthy Subjects Drug: ASP1707|Drug: itraconazole Astellas Pharma Europe B.V.|Astellas Pharma Inc Phase 1 2014-04-01 2014-07-01
    NCT01259336 Chronic Cavitary Pulmonary Aspergillosis Drug: Itraconazole|Drug: treatment in cavitary pulmonary aspergillosis Postgraduate Institute of Medical Education and Research Phase 4 2010-07-01 2012-02-18
    NCT01450683 Prostate Cancer|Prostatic Neoplasms|Castrate-resistant Prostate Cancer (CRPC)|Androgen-insensitive Prostate Cancer|Hormone-refractory Prostate Cancer|Metastatic Disease Drug: Itraconazole Stanford University Phase 2 2010-09-01 2014-08-29
    NCT02475746 Healthy Drug: PF-06372865|Drug: itraconazole Pfizer Phase 1 2015-07-01 2015-07-22

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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