Tenofovir能阻断HIV-1和HBV的逆转录酶,对HIV-1和HIV-2的IC50分别为0.5-2.2 uM和1.6-4.9 uM。
Tenofovir blocks reverse transcriptase and hepatitis B virus infections.
30 mg/kg皮下注射
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Witvrouw M, et al. Antivir Ther, 2004, 9(1), 57-65.
[2] Van Rompay, K.K., et al. 1996. Antimicrob. Agents Chemother. 40: 2586-2591.
[3] Cihlar, T., et al. 2002. Antiviral Res. 54: 37-45.
分子式 C9H14N5O4P |
分子量 287.21 |
CAS号 147127-20-6 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 10 mM |
Water 2 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT00651209 | Hepatitis B, Chronic | Drug: Tenofovir | Novartis Pharmaceuticals|Novartis | Phase 4 | 2008-02-01 | 2014-03-06 |
NCT00903084 | HIV | Drug: Tenofovir Disoproxil Fumarate | Public Health Foundation Enterprises, Inc.|National Institute of Mental Health (NIMH) | Phase 1 | 2009-06-01 | 2015-04-02 |
NCT01848743 | Chronic HBV With Severe Exacerbation | Drug: Tenofovir|Drug: lamivudine | Kaohsiung Veterans General Hospital. | Phase 3 | 2013-04-01 | 2014-09-12 |
NCT00648817 | HIV Infections | Drug: Tenofovir Disoproxil Fumarate|Drug: Tenofovir DF placebo | Gilead Sciences | Phase 4 | 2006-07-01 | 2008-03-31 |
NCT02463019 | Chronic Hepatitis B|Antiviral Treatment | Drug: Tenofovir Disoproxil Fumarate | E-DA Hospital|Taipei Institute of Pathology | Phase 4 | 2015-01-01 | 2015-06-02 |
NCT02585947 | Non-Hodgkin's Lymphoma, Burkitt's | Drug: Tenofovir | Seoul National University Hospital|Gilead Sciences|Konkuk University Hospital | Phase 4 | 2015-11-01 | 2016-12-20 |
NCT00119106 | HIV Infections | Device: Tenofovir | Centers for Disease Control and Prevention|Ministry of Health, Thailand|Bangkok Metropolitan Administration Medical College and Vajira Hospital | Phase 2|Phase 3 | 2005-06-01 | 2015-02-04 |
NCT02479880 | Hepatitis B | Drug: Tenofovir DF|Radiation: DEXA Scan | Gilead Sciences | Phase 4 | 2015-07-01 | 2017-01-12 |
NCT01334567 | Hepatitis B | Drug: Tenofovir DF | Gilead Sciences | Phase 2 | 2010-08-01 | 2014-02-28 |
NCT01260610 | Chronic Hepatitis B | Drug: Tenofovir|Drug: Telbivudine|Drug: Tenofovir plus Telbivudine | Institute of Liver and Biliary Sciences, India | 2011-06-01 | 2015-06-15 | |
NCT01872988 | Chronic Hepatitis B|Hepatocellular Carcinoma | Drug: Tenofovir|Drug: Placebo | Taichung Veterans General Hospital|Gilead Sciences|Taipei Institute of Pathology | Phase 3 | 2012-09-01 | 2014-09-03 |
NCT02995005 | Hepatitis B | Drug: Tenofovir Disoproxil Fumarate | Johns Hopkins Bloomberg School of Public Health|Thrasher Research Fund|Shoklo Malaria Research Unit|Chiang Mai University | Phase 1|Phase 2 | 2017-08-01 | 2017-02-28 |
NCT00036634 | HIV Infections | Drug: Tenofovir DF|Drug: Tenofovir alafenamide | Gilead Sciences | Phase 1|Phase 2 | 2002-03-01 | 2014-01-13 |
NCT02533544 | Chronic Hepatitis B | Drug: tenofovir disoproxil fumarate | Myeong Jun Song|Gilead Sciences|Wonkwang University|Soonchunhyang University Hospital|Chungnam National University Hospital|Konyang University Hospital|The Catholic University of Korea | 2015-10-01 | 2016-06-01 | |
NCT01639092 | Chronic Viral Hepatitis B Without Delta-agent | Drug: Tenofovir|Drug: Tenofovir|Drug: Entecavir | Asan Medical Center|Samsung Medical Center|Konkuk University Medical Center|Korea University Guro Hospital|Seoul National University Hospital | Phase 4 | 2012-09-01 | 2016-07-24 |
NCT01711567 | Chronic Hepatitis B | Drug: tenofovir|Drug: entecavir | Korea University|Gilead Sciences | Phase 4 | 2013-04-01 | 2016-11-08 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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