Tenofovir

替诺福韦,GS 1278, PMPA, Viread, TDF

Tenofovir能阻断HIV-1和HBV的逆转录酶,对HIV-1和HIV-2的IC50分别为0.5-2.2 uM和1.6-4.9 uM。

目录号
EY1722
EY1722
EY1722
EY1722
纯度
99.43%
99.43%
99.43%
99.43%
规格
5 mg
10 mg
50 mg
100 mg
原价
345
515
998
1410
售价
345
515
998
1410
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Tenofovir blocks reverse transcriptase and hepatitis B virus infections.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

    30 mg/kg皮下注射

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Witvrouw M, et al. Antivir Ther, 2004, 9(1), 57-65.
    [2] Van Rompay, K.K., et al. 1996. Antimicrob. Agents Chemother. 40: 2586-2591.
    [3] Cihlar, T., et al. 2002. Antiviral Res. 54: 37-45.

    分子式
    C9H14N5O4P
    分子量
    287.21
    CAS号
    147127-20-6
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    10 mM
    Water
    2 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT00651209 Hepatitis B, Chronic Drug: Tenofovir Novartis Pharmaceuticals|Novartis Phase 4 2008-02-01 2014-03-06
    NCT00903084 HIV Drug: Tenofovir Disoproxil Fumarate Public Health Foundation Enterprises, Inc.|National Institute of Mental Health (NIMH) Phase 1 2009-06-01 2015-04-02
    NCT01848743 Chronic HBV With Severe Exacerbation Drug: Tenofovir|Drug: lamivudine Kaohsiung Veterans General Hospital. Phase 3 2013-04-01 2014-09-12
    NCT00648817 HIV Infections Drug: Tenofovir Disoproxil Fumarate|Drug: Tenofovir DF placebo Gilead Sciences Phase 4 2006-07-01 2008-03-31
    NCT02463019 Chronic Hepatitis B|Antiviral Treatment Drug: Tenofovir Disoproxil Fumarate E-DA Hospital|Taipei Institute of Pathology Phase 4 2015-01-01 2015-06-02
    NCT02585947 Non-Hodgkin's Lymphoma, Burkitt's Drug: Tenofovir Seoul National University Hospital|Gilead Sciences|Konkuk University Hospital Phase 4 2015-11-01 2016-12-20
    NCT00119106 HIV Infections Device: Tenofovir Centers for Disease Control and Prevention|Ministry of Health, Thailand|Bangkok Metropolitan Administration Medical College and Vajira Hospital Phase 2|Phase 3 2005-06-01 2015-02-04
    NCT02479880 Hepatitis B Drug: Tenofovir DF|Radiation: DEXA Scan Gilead Sciences Phase 4 2015-07-01 2017-01-12
    NCT01334567 Hepatitis B Drug: Tenofovir DF Gilead Sciences Phase 2 2010-08-01 2014-02-28
    NCT01260610 Chronic Hepatitis B Drug: Tenofovir|Drug: Telbivudine|Drug: Tenofovir plus Telbivudine Institute of Liver and Biliary Sciences, India 2011-06-01 2015-06-15
    NCT01872988 Chronic Hepatitis B|Hepatocellular Carcinoma Drug: Tenofovir|Drug: Placebo Taichung Veterans General Hospital|Gilead Sciences|Taipei Institute of Pathology Phase 3 2012-09-01 2014-09-03
    NCT02995005 Hepatitis B Drug: Tenofovir Disoproxil Fumarate Johns Hopkins Bloomberg School of Public Health|Thrasher Research Fund|Shoklo Malaria Research Unit|Chiang Mai University Phase 1|Phase 2 2017-08-01 2017-02-28
    NCT00036634 HIV Infections Drug: Tenofovir DF|Drug: Tenofovir alafenamide Gilead Sciences Phase 1|Phase 2 2002-03-01 2014-01-13
    NCT02533544 Chronic Hepatitis B Drug: tenofovir disoproxil fumarate Myeong Jun Song|Gilead Sciences|Wonkwang University|Soonchunhyang University Hospital|Chungnam National University Hospital|Konyang University Hospital|The Catholic University of Korea 2015-10-01 2016-06-01
    NCT01639092 Chronic Viral Hepatitis B Without Delta-agent Drug: Tenofovir|Drug: Tenofovir|Drug: Entecavir Asan Medical Center|Samsung Medical Center|Konkuk University Medical Center|Korea University Guro Hospital|Seoul National University Hospital Phase 4 2012-09-01 2016-07-24
    NCT01711567 Chronic Hepatitis B Drug: tenofovir|Drug: entecavir Korea University|Gilead Sciences Phase 4 2013-04-01 2016-11-08

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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