Vincristine

长春新碱,Leurocristine

Vincristine通过与微管蛋白结合而抑制微管聚合,IC50为32 μM。

目录号
EY1704
EY1704
EY1704
EY1704
纯度
99.07%
99.07%
99.07%
99.07%
规格
5 mg
10 mg
50 mg
100 mg
原价
335
545
2080
3320
售价
335
545
2080
3320
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Vincristine is a naturally occurring alkaloid that potently inhibits the tubulin addition with the inhibition constant Ki value of 0.085 μM and exhibits an anti-proliferative activity against B16 melanoma cells with the half maximal inhibition concentration IC50 value of 0.45 M.

  • 体外研究

  • 体内研究

    Saline

  • 激酶实验

  • 细胞实验

    10 nM

  • 动物实验

    3 mg/kg 腹腔注射

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Jordan MA, et al. Cancer Res, 1985, 45(6), 2741-2747.
    [2] Li, Y., et al. 1992. Biochem. Biophys. Res. Commun. 187: 722-729.
    [3] Zhang, J., et al. 1996. Proc. Natl. Acad. Sci. U.S.A. 93: 5325-5328.

    分子式
    C46H58N4O14S
    分子量
    923.04
    CAS号
    2068-78-2
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    90 mg/mL
    Water
    40 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00038207 Soft Tissue Sarcoma|Lymphoma|Leukemia|Wilms' Tumor|Osteosarcoma Drug: Liposomal Vincristine M.D. Anderson Cancer Center|Inex Pharmaceuticals Phase 2 2000-06-01 2012-07-27
    NCT00555464 Hemangioma Drug: Vincristine|Drug: Prednisone Medical College of Wisconsin|FDA Office of Orphan Products Development Phase 2 2007-11-01 2013-06-04
    NCT01222780 Sarcoma|Neuroblastoma|Wilms Tumor|Leukemia|Lymphoma|Brain Tumors Drug: Marqibo Spectrum Pharmaceuticals, Inc|National Cancer Institute (NCI) Phase 1|Phase 2 2010-09-01 2015-05-26
    NCT02337478 Recurrent Adult Acute Myeloid Leukemia Drug: Vincristine Sulfate Liposome|Other: Laboratory Biomarker Analysis Wake Forest University Health Sciences|National Cancer Institute (NCI)|Spectrum Pharmaceuticals, Inc Phase 2 2015-05-01 2017-01-17
    NCT01397825 Diffuse Large B-Cell Lymphoma|Transformed Follicular Lymphoma|Mantle Cell Lymphoma|Burkitt's Lymphoma Drug: Alisertib (MLN8237) + Rituximab + Vincristine Millennium Pharmaceuticals, Inc.|Takeda Phase 1|Phase 2 2011-08-01 2016-11-17
    NCT00022555 AIDS-related Diffuse Large Cell Lymphoma|AIDS-related Diffuse Mixed Cell Lymphoma|AIDS-related Peripheral/Systemic Lymphoma|AIDS-related Small Noncleaved Cell Lymphoma Drug: bryostatin 1|Drug: vincristine sulfate National Cancer Institute (NCI) Phase 1 2001-11-01 2013-01-24
    NCT00145041 Malignant Melanoma Drug: Vincristine Sulfate Liposomes Injection Spectrum Pharmaceuticals, Inc Phase 1 2005-02-01 2014-03-27
    NCT02923388 Vincristine Induced Peripheral Neuropathy (VIPN) Drug: Injection Mecobalamin,|Drug: Tablet Pyridoxine hydrochloride|Drug: Intravenous normal saline 1 ml|Drug: Placebo pill Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh Phase 2 2016-10-01 2016-10-14
    NCT00058305 Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Nodal Marginal Zone B-cell Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Small Lymphocytic Lymphoma|Splenic Marginal Zone Lymphoma Drug: bryostatin 1|Drug: vincristine sulfate|Other: laboratory biomarker analysis National Cancer Institute (NCI) Phase 2 2003-03-01 2013-01-09
    NCT02861040 Recurrent Adult Acute Lymphoblastic Leukemia|Refractory Adult Acute Lymphoblastic Leukemia Other: Laboratory Biomarker Analysis|Other: Pharmacological Study|Drug: Vincristine Sulfate Liposome|Drug: Volasertib Northwestern University|National Comprehensive Cancer Network|National Cancer Institute (NCI) Phase 1 2016-08-01 2016-12-13
    NCT00003166 Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Refractory Chronic Lymphocytic Leukemia|Refractory Multiple Myeloma|Stage III Multiple Myeloma Drug: bryostatin 1|Drug: vincristine sulfate|Other: laboratory biomarker analysis National Cancer Institute (NCI) Phase 1 1998-05-01 2013-01-10
    NCT00901069 Lymphoma|Hodgkin Disease|Lymphoma, Non-Hodgkin Drug: Azacitidine with rituximab, vincristine, and cyclophosphamide Shams Shakil|Celgene|University of Kentucky Phase 1 2009-05-01 2016-10-13
    NCT00144963 Acute Lymphoblastic Leukemia Drug: Vincristine Sulfate Liposomes Injection|Drug: Dexamethasone Spectrum Pharmaceuticals, Inc Phase 1|Phase 2 2002-07-01 2014-03-27
    NCT02360930 Leukemia, Acute Lymphoblastic|Leukemia Children's Hospital Los Angeles 2014-09-01 2015-06-18
    NCT01439347 Acute Lymphoblastic Leukemia (ALL) Drug: Vincristine Sulfate Liposomes Injection (VSLI)|Drug: Vincristine Sulfate Injection (VSI) Spectrum Pharmaceuticals, Inc Phase 3 2012-03-01 2016-07-20
    NCT02879643 ALL, Childhood|Lymphoblastic Leukemia, Acute, Childhood|Lymphoblastic Leukemia, Acute Drug: Marqibo in combination with UK ALL R3 Therapeutic Advances in Childhood Leukemia Consortium|Spectrum Pharmaceuticals, Inc Phase 1 2016-07-01 2017-01-25

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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