Ciprofloxacin是氟喹诺酮类广谱抗生素。
Ciprofloxacin is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Wise R, et al. Antimicrob Agents Chemother, 1983, 23(4), 559-564.
[2] Hoffken, G., et al.: Antimicrob. Ag. Chemother., 27, 375 (1985)
[3] Scully, B.E., et al.: Lancet, 1, 819 (1986)
分子式 C17H18FN3O3 |
分子量 331.34 |
CAS号 85721-33-1 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO <1 mg/mL |
Water Insoluble |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02724046 | Meningitis, Meningococcal | Drug: Ciprofloxacin | Epicentre|Medecins Sans Frontieres, Netherlands | Phase 4 | 2017-01-01 | 2016-09-21 |
NCT00992329 | Healthy | Drug: ciprofloxacin | University of Maryland|Food and Drug Administration (FDA) | Phase 1 | 2013-01-01 | 2013-11-21 |
NCT02967341 | Childhood Cancer|Neutropenia | Other: Ciprofloxacin administration | Universitair Ziekenhuis Brussel | Phase 4 | 2016-03-01 | 2016-11-15 |
NCT02773732 | Leukemia|Acute Myelogenous Leukemia|Acute Myeloid Leukemia | Drug: Ciprofloxacin|Drug: Etoposide | University of Florida | Phase 1|Phase 2 | 2016-09-01 | 2016-09-22 |
NCT02961751 | Gonorrhoea | Drug: Ciprofloxacin | National Institute of Allergy and Infectious Diseases (NIAID) | 2016-09-13 | 2017-03-02 | |
NCT01789203 | BK Virus Infection | Drug: Ciprofloxacin|Drug: placebo | The Methodist Hospital System | Phase 4 | 2013-01-01 | 2016-03-15 |
NCT00609973 | Crohn's Disease | Drug: Ciprofloxacin|Drug: Placebo | University of North Carolina, Chapel Hill|Crohn's and Colitis Foundation|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Phase 2 | 2008-05-01 | 2013-03-21 |
NCT01402947 | Healthy | Drug: Ciprofloxacin XR + MMX Placebo|Drug: MMX Mesalazine/mesalamine + Ciprofloxacin XR | Shire | Phase 1 | 2011-07-01 | 2012-06-01 |
NCT01157819 | Otitis Externa|Otorhinolaryngologic Diseases|Ear Diseases|Otitis | Drug: 0.3% Ciprofloxacin Ear Drops|Drug: FoamOtic Cipro | Otic Pharma | Phase 2 | 2010-07-01 | 2011-03-14 |
NCT00910351 | Pseudomonas Infection | Drug: Ciprofloxacin (Cipro, BAYQ3939) | Bayer | Phase 1 | 2009-07-01 | 2013-11-20 |
NCT02661438 | Bronchiectasis|Pulmonary Disease, Chronic Obstructive | Drug: Placebo to Ciprofloxacin DPI (BAYQ3939) | Bayer|Novartis | 2016-01-01 | 2016-04-06 | |
NCT00668044 | Burns|Bacterial Infections | Drug: Ciprofloxacin (BAYO9867)|Drug: Ciprofloxacin (BAYO9867) | Bayer | Phase 3 | 2002-11-01 | 2009-10-26 |
NCT02326103 | Alcoholic Hepatitis|Alcoholic Cirrhosis | Drug: Ciprofloxacin|Drug: Placebo | Helsinki University | Early Phase 1 | 2015-04-01 | 2017-01-18 |
NCT00431028 | Inflammation|Bacterial Infections | Device: slow delivery ciprofloxacin + triamcinolone | Federal University of S茫o Paulo | Phase 1|Phase 2 | 2005-09-01 | 2008-03-06 |
NCT01753115 | Anthrax | Biological: BioThrax|Drug: Ciprofloxacin | Emergent BioSolutions|Department of Health and Human Services | Phase 2 | 2012-12-01 | 2014-11-18 |
NCT02598362 | Urinary Tract Infection|Pyelonephritis | Drug: ciprofloxacin | University Hospital, Ghent|Universitair Ziekenhuis Brussel | Phase 4 | 2015-04-01 | 2015-11-04 |
NCT00481689 | Urinary Tract Infections | Drug: Cipro XR (Ciprofloxacin, BAYQ3939) | Bayer | Phase 4 | 2004-05-01 | 2009-06-25 |
NCT00785980 | Healthy | Drug: Quinine Sulfate Capsules 324 mg|Drug: Ciprofloxacin 500 mg|Drug: Quinine Sulfate Capsules 324 mg | Mutual Pharmaceutical Company, Inc. | Phase 1 | 2008-09-01 | 2012-07-31 |
NCT00930982 | Bronchiectasis | Drug: Ciprofloxacin (Cipro, BAYQ3939)|Drug: Placebo | Bayer|Novartis | Phase 2 | 2009-06-01 | 2014-11-28 |
NCT01319435 | Pharmacokinetics of Ciprofloxacin in Neonates | Procedure: Collection of biological samples | Liverpool Women's NHS Foundation Trust|University of Liverpool | Phase 1 | 2011-01-01 | 2015-10-09 |
NCT01542801 | Adverse Reaction to Other Drugs and Medicines | Drug: Norfloxacin|Drug: ciprofloxacin | Korea University|Sungkyunkwan University|Kyungpook National University|Soon Chun Hyang University | Phase 4 | 2011-08-01 | 2016-12-27 |
NCT00194532 | Urinary Tract Infection | Drug: Cefpodoxime|Drug: Ciprofloxacin | University of Washington | 2005-06-01 | 2014-06-03 | |
NCT00741052 | Cholera | Drug: Ciprofloxacin|Drug: Azithromycin | International Centre for Diarrhoeal Disease Research, Bangladesh | Phase 3 | 2007-07-01 | 2011-07-11 |
NCT01243437 | Plague | Drug: ciprofloxacin|Drug: doxyxcycline | Centers for Disease Control and Prevention|MRC/UVRI Uganda Research Unit on Aids|Ministry of Health, Uganda | Phase 2 | 2010-12-01 | 2012-09-10 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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