Dorsomorphin 2HCl是一种有效的,可逆的AMPK选择性抑制剂,Ki为109 nM,对ZAPK, SYK, PKCθ, PKA和JAK3没有显著的抑制作用。
Dorsomorphin 2HCl是一种有效的,可逆的AMPK选择性抑制剂,Ki为109 nM,对一些结构相关的激酶,包括ZAPK, SYK, PKCθ, PKA和JAK3没有显著的抑制作用。同时抑制了BMP一型受体作用。
1% DMSO+30% polyethylene glycol+1% Tween 80
~10 mg/kg 静脉注射
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Zhou G, et al. J Clin Invest. 2001, 108(8), 1167-1174.
[2] Vucicevic et al (2011) Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway. Autophagy 7 40.
[3] Diekmann et al (2015) A reliable and efficient protocol for human pluripotent stem cell differentiation into the definitive endoderm based on dispersed single cells. Stem Cells Dev. 24 190.
[4] Hao et al (2008) Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells. PLoS ONE 3 2904.
分子式 C24H25N5O.2HCl |
分子量 472.41 |
CAS号 1219168-18-9 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 20 mM |
Water 100 mM |
Ethanol <1 mg/mL |
体内溶解度
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注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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