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SN-38

7-Ethyl-10-hydroxycamptothecin

SN-38是CPT-11的一种活性代谢物，抑制DNA topoisomerase I（DNA拓扑异构酶I） ，IC50为1 μM，抑制DNA合成，且造成频繁的DNA单链断裂。

目录号
EY1650
EY1650
纯度
99.33%
99.33%
规格
50 mg
100 mg
原价
390
572
售价
390
572
库存
现货
现货
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  • 生物活性

    SN-38(NK-012) is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

    0 -1000 nM

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Kawato Y, et al. Cancer Res, 1991, Aug 15, 51(16), 4187-4191.
    [2] Koizumi, F., et al. 2006. Cancer Res. 66: 10048-10056.
    [3] Gao, H., et al. 2005. Bioorg. Med. Chem. Lett. 15: 3233-3236.

    分子式
    C22H20N2O5    		 分子量
    392.4    		 CAS号
    86639-52-3    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    25 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00311610 Colorectal Cancer Drug: SN-38 liposome Alliance for Clinical Trials in Oncology|National Cancer Institute (NCI) Phase 2 2006-01-01 2016-06-28
    NCT00104754 Lung Cancer Drug: liposomal SN-38 Alliance for Clinical Trials in Oncology|National Cancer Institute (NCI) Phase 2 null 2016-07-19
    NCT00734682 Glioblastoma|Gliosarcoma|Anaplastic Astrocytoma|Anaplastic Oligodendroglioma Drug: Nanoliposomal CPT-11 University of California, San Francisco Phase 1 2008-08-01 2015-01-05
    NCT00509860 Sarcoma Drug: Irinotecan M.D. Anderson Cancer Center Phase 2 2003-03-01 2012-12-28
    NCT02171325 Small Cell Lung Cancer Drug: irinotecan Guangdong Association of Clinical Trials Phase 2 2014-06-01 2014-06-20
    NCT00644696 Neuroblastoma Drug: Irinotecan and Bortezomib University of Michigan Cancer Center|Millennium Pharmaceuticals, Inc. Phase 1 2008-04-01 2016-06-02
    NCT01607554 Non-small Cell Lung Cancer Drug: Irinotecan New Mexico Cancer Care Alliance|University of New Mexico Cancer Center|Lovelace Respiratory Research Institute Phase 1|Phase 2 2012-04-01 2016-06-07
    NCT00969033 Metastatic Colorectal Cancer Drug: CS-1008|Drug: irinotecan Daiichi Sankyo Inc. Phase 2 2009-07-01 2012-01-30
    NCT00353015 Gastrointestinal Cancer|Carcinoma, Neuroendocrine Drug: Cisplatin|Drug: Irinotecan M.D. Anderson Cancer Center|Pharmacia Phase 2 2003-03-01 2012-08-01
    NCT00808184 Solid Tumor Drug: CPT-11, Raltegravir (Isentress庐), Midazolam National University Hospital, Singapore Phase 4 2010-04-01 2012-10-31
    NCT00003748 Esophageal Cancer|Gastric Cancer Drug: irinotecan hydrochloride Jonsson Comprehensive Cancer Center|National Cancer Institute (NCI)|Pharmacia and Upjohn Phase 2 1998-08-01 2015-10-28
    NCT01654081 Lung Cancer Drug: Irinotecan Susanne Arnold|University of Kentucky Phase 2 2013-10-01 2014-05-28
    NCT01114555 Neuroblastoma Drug: Bevacizumab, Irinotecan and Temozolomide Memorial Sloan Kettering Cancer Center|Genentech, Inc. Phase 2 2010-04-01 2016-05-09
    NCT01016860 Colorectal Cancer Drug: OSI-906|Drug: irinotecan University of Colorado, Denver Phase 1 2009-12-01 2013-10-18
    NCT00563316 Metastatic Colorectal Cancer Drug: Panitumumab|Drug: Irinotecan Amgen Phase 1 2008-03-01 2016-03-14
    NCT01036113 Metastatic Breast Cancer Drug: EZN-2208 Enzon Pharmaceuticals, Inc. Phase 2 2009-11-01 2012-10-01
    NCT00532714 Breast Cancer Metastatic Drug: Irinotecan plus capecitabine National Cancer Center, Korea Phase 2 2006-08-01 2011-12-27
    NCT03053167 ColoRectal Cancer Drug: Irinotecan|Drug: Raltitrexed China Medical University, China|The First Affiliated Hospital of Dalian Medical University|The Second Affiliated Hospital of Dalian Medical University|Liaoning Tumor Hospital & Institute|Shengjing Hospital|General Hospital of Shenyang Military Region Phase 2 2016-12-01 2017-02-13
    NCT01847495 Colorectal Cancer Drug: Irinotecan|Radiation: CyberKnife Advocate Health Care 2013-10-01 2017-01-26
    NCT01826396 Colonic Neoplasms Drug: Irinotecan Colorectal Cancer Institute of the Heilongjiang Academy of Medical Sciences Phase 2 2013-04-01 2013-04-04

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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