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Rosiglitazone maleate

马来酸罗格列酮,BRL 49653

Rosiglitazone maleate是一种噻唑烷二酮类抗高血糖药，是过氧化物酶体增生物激活受体-γ的高亲和，选择性的激动剂。

目录号
EY1631
EY1631
EY1631
纯度
99.23%
99.23%
99.23%
规格
50 mg
100 mg
200 mg
原价
400
660
1000
售价
400
660
1000
库存
现货
现货
现货
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  • 生物活性

    Rosiglitazone maleate (Avandia) is a potent and selective PPARγ ligand that binds to the PPARγ ligand-binding domain with a Kd value of 43 nM.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Deeks ED, et al. Drugs, 2007, 67(18), 2747-2779.

    分子式
    C18H19N3O3S.C4H4O4    		 分子量
    473.5    		 CAS号
    155141-29-0    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    100 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    2 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01706211 Diabetes Mellitus Non Insulin Dependent Oral Agent Therapy Drug: BRL 49653C|Drug: Placebo National Taiwan University Hospital Phase 3 1998-10-01 2012-10-12
    NCT00785213 Healthy Drug: Rosiglitazone 4 mg Tablets|Drug: Rosiglitazone 4 mg Tablets|Drug: Quinine Sulfate 324 mg Capsules Mutual Pharmaceutical Company, Inc.|Cetero Research, San Antonio Phase 1 2008-09-01 2012-07-31
    NCT00369174 Oral Leukoplakia Drug: rosiglitazone maleate|Other: laboratory biomarker analysis National Cancer Institute (NCI) Phase 2 2006-06-01 2013-02-12
    NCT00182052 Adenocarcinoma of the Prostate|Prostate Cancer Drug: Rosiglitazone|Other: Placebo Massachusetts General Hospital|Dana-Farber Cancer Institute Phase 3 2000-09-01 2013-05-22
    NCT00065065 Ulcerative Colitis|Inflammatory Bowel Disease Drug: Rosiglitazone|Drug: Placebo James Lewis|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|GlaxoSmithKline|University of Pennsylvania Phase 2 2002-09-01 2015-12-04
    NCT00616642 Brain and Central Nervous System Tumors Drug: rosiglitazone maleate Jonsson Comprehensive Cancer Center|National Cancer Institute (NCI) Phase 2 2006-10-01 2013-03-04
    NCT01100619 Papillary Thyroid Cancer|Follicular Thyroid Cancer|Huerthle Cell Thyroid Cancer|Renal Cell Carcinoma Drug: rosiglitazone|Drug: XL184 Exelixis Phase 1 2010-04-01 2013-09-17
    NCT00486187 Type 2 Diabetes Mellitus Drug: rosiglitazone|Drug: metformin or sulfonylurea Dr. Milan Gupta|GlaxoSmithKline|Canadian Collaborative Research Network 2006-04-01 2016-01-27
    NCT00169832 Diabetes|Coronary Artery Bypass Grafting Drug: Rosiglitazone or placebo Laval University|GlaxoSmithKline Phase 3 2003-06-01 2008-10-09
    NCT00207402 Hepatitis C Drug: rosiglitazone Brooke Army Medical Center|InterMune Phase 4 2005-10-01 2012-02-13
    NCT00004180 Sarcoma Drug: rosiglitazone maleate Dana-Farber Cancer Institute|National Cancer Institute (NCI) Phase 2 1999-10-01 2017-02-09
    NCT00523913 Diabetes Mellitus, Type 2 Drug: rosiglitazone GlaxoSmithKline Phase 3 2005-11-01 2016-10-26
    NCT00242593 Mild Cognitive Impairment Drug: Rosiglitazone University of Washington|National Institute on Aging (NIA)|GlaxoSmithKline Phase 2 2006-06-01 2011-08-04
    NCT00746174 Insulin Sensitivity Drug: Rosiglitazone|Drug: Placebo University of Texas Southwestern Medical Center|GlaxoSmithKline Phase 4 2004-02-01 2008-09-02
    NCT00405015 Ischemia-Reperfusion Injury|The Metabolic Syndrome Drug: rosiglitazone Radboud University|GlaxoSmithKline Phase 2 2007-04-01 2010-08-23
    NCT00381238 Alzheimer's Disease Drug: rosiglitazone GlaxoSmithKline Phase 2 2006-06-01 2016-10-26
    NCT02694874 Malaria Drug: Rosiglitazone|Drug: Placebo Centro de Investigacao em Saude de Manhica|University Health Network, Toronto|Barcelona Institute for Global Health 2016-02-01 2016-07-07
    NCT00819910 Hypertriglyceridemia in Type 4 Hyperlipidemia|Non Diabetic Subjects With Normoglycemia Drug: Rosiglitazone|Drug: Placebo (Rosiglitazone)|Drug: Placebo (Fenofibrate)|Drug: Fenofibrate Ahmad Slim|GlaxoSmithKline|Brooke Army Medical Center Phase 4 2008-09-01 2014-04-08
    NCT02526615 Insulin Sensitivity|Type 2 Diabetes Drug: Rosiglitazone|Drug: Metformin|Drug: Placebo Turku University Hospital|SmithKline Beecham Phase 4 2000-10-01 2015-08-14
    NCT00367744 HIV Infections Drug: Rosiglitazone|Drug: Placebo National Institute of Allergy and Infectious Diseases (NIAID)|GlaxoSmithKline Phase 2 2006-07-01 2016-12-08

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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