Home > Topoisomerase & > Irinotecan

Irinotecan

伊立替康,依立替康,依林特肯,CPT-11

Irinotecan(CPT-11)能通过抑制拓扑异构酶1阻止DNA的解旋。

目录号
EY1615
EY1615
EY1615
纯度
99.36%
99.36%
99.36%
规格
50 mg
100 mg
500 mg
原价
500
800
2000
售价
500
800
2000
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
具体折扣请咨询客服

  • 生物活性

    (+)-Irinotecan is an isomer of the Topo I inhibitor Irinotecan.

  • 体外研究

  • 体内研究

    30% Propylene glycol, 5% Tween 80, 65% D5W(5%葡萄糖水溶液)

  • 激酶实验

  • 细胞实验

    0 μM -100 μM

  • 动物实验

    20 mg/kg 腹腔注射给药

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Pavillard V, et al. Cancer Chemother Pharmacol. 2002, 49(4), 329-335.

    分子式
    C33H38N4O6    		 分子量
    586.68    		 CAS号
    97682-44-5    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    10 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00509860 Sarcoma Drug: Irinotecan M.D. Anderson Cancer Center Phase 2 2003-03-01 2012-12-28
    NCT02171325 Small Cell Lung Cancer Drug: irinotecan Guangdong Association of Clinical Trials Phase 2 2014-06-01 2014-06-20
    NCT00644696 Neuroblastoma Drug: Irinotecan and Bortezomib University of Michigan Cancer Center|Millennium Pharmaceuticals, Inc. Phase 1 2008-04-01 2016-06-02
    NCT01654081 Lung Cancer Drug: Irinotecan Susanne Arnold|University of Kentucky Phase 2 2013-10-01 2014-05-28
    NCT01607554 Non-small Cell Lung Cancer Drug: Irinotecan New Mexico Cancer Care Alliance|University of New Mexico Cancer Center|Lovelace Respiratory Research Institute Phase 1|Phase 2 2012-04-01 2016-06-07
    NCT00969033 Metastatic Colorectal Cancer Drug: CS-1008|Drug: irinotecan Daiichi Sankyo Inc. Phase 2 2009-07-01 2012-01-30
    NCT00353015 Gastrointestinal Cancer|Carcinoma, Neuroendocrine Drug: Cisplatin|Drug: Irinotecan M.D. Anderson Cancer Center|Pharmacia Phase 2 2003-03-01 2012-08-01
    NCT01114555 Neuroblastoma Drug: Bevacizumab, Irinotecan and Temozolomide Memorial Sloan Kettering Cancer Center|Genentech, Inc. Phase 2 2010-04-01 2016-05-09
    NCT00003748 Esophageal Cancer|Gastric Cancer Drug: irinotecan hydrochloride Jonsson Comprehensive Cancer Center|National Cancer Institute (NCI)|Pharmacia and Upjohn Phase 2 1998-08-01 2015-10-28
    NCT00532714 Breast Cancer Metastatic Drug: Irinotecan plus capecitabine National Cancer Center, Korea Phase 2 2006-08-01 2011-12-27
    NCT01016860 Colorectal Cancer Drug: OSI-906|Drug: irinotecan University of Colorado, Denver Phase 1 2009-12-01 2013-10-18
    NCT00183859 Adenocarcinoma|Gastric Cancer Drug: irinotecan University of Southern California Phase 1 1999-09-01 2014-05-20
    NCT00005626 Leukemia|Lymphoma Drug: Irinotecan H. Lee Moffitt Cancer Center and Research Institute|National Cancer Institute (NCI)|Upjohn Phase 2 1998-02-01 2012-09-24
    NCT01847495 Colorectal Cancer Drug: Irinotecan|Radiation: CyberKnife Advocate Health Care 2013-10-01 2017-01-26
    NCT00563316 Metastatic Colorectal Cancer Drug: Panitumumab|Drug: Irinotecan Amgen Phase 1 2008-03-01 2016-03-14
    NCT03053167 ColoRectal Cancer Drug: Irinotecan|Drug: Raltitrexed China Medical University, China|The First Affiliated Hospital of Dalian Medical University|The Second Affiliated Hospital of Dalian Medical University|Liaoning Tumor Hospital & Institute|Shengjing Hospital|General Hospital of Shenyang Military Region Phase 2 2016-12-01 2017-02-13
    NCT01004159 Colorectal Cancer Drug: cetuximab with irinotecan Roswell Park Cancer Institute|Bristol-Myers Squibb Phase 2 2009-09-01 2015-09-29
    NCT01239485 Acute Leukemia Drug: Irinotecan Seoul National University Hospital Phase 1 2010-11-01 2013-11-17
    NCT01826396 Colonic Neoplasms Drug: Irinotecan Colorectal Cancer Institute of the Heilongjiang Academy of Medical Sciences Phase 2 2013-04-01 2013-04-04
    NCT00671801 Malignant Gliomas Drug: Irinotecan|Drug: Lenalidomide M.D. Anderson Cancer Center|Celgene Corporation Phase 1 2008-04-01 2015-02-16
    NCT00856830 Small Cell Lung Cancer|Extensive Stage Lung Cancer|Chemonaive Drug: Bendamustine, Irinotecan, Etoposide/Carboplatin (Novel drug combination) University of Alabama at Birmingham|National Comprehensive Cancer Network Phase 1|Phase 2 2009-03-01 2016-07-07
    NCT01574092 Pediatric High Risk Gliomas Drug: Combination of two marketed drugs (irinotecan and cisplatin) Hospital Sant Joan de Deu|Fundaci贸 Sant Joan de D茅u|Spanish National Health System Phase 2 2009-11-01 2015-08-21
    NCT00360828 Astrocytoma|Glioma|Oligodendroglioma Drug: Irinotecan Hydrochloride (HCI) Treatment|Drug: Continued Irinotecan Hydrochloride (HCI) Treatment H. Lee Moffitt Cancer Center and Research Institute Phase 2 2006-02-01 2017-02-20
    NCT00183872 Gastric Cancer|Esophageal Neoplasms Drug: irinotecan, docetaxel University of Southern California|Sanofi Phase 2 2005-04-01 2015-10-24
    NCT02318589 Solid Tumor Drug: Irinotecan + Eribulin Tom Badgett|University of Kentucky Phase 1 2015-08-01 2016-10-14
    NCT02720601 Biliary Tract Cancer Drug: Irinotecan & Capecitabine New Mexico Cancer Care Alliance Phase 2 2015-11-01 2016-03-28

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

  • 相关化合物库

  • 使用AMQUAR产品发表文献后请联系我们

相关推荐

X
  • 联系人 ：
  • 收件地址 ：
  • 电话号码 ：
  • 单位名称 ：
  • 产品货号 ：
  • 产品规格 ：
  • 发票抬头以及单位税号 ：