Acetylcysteine是营养补充剂。
Acetylcysteine is a derivative of cysteine; an acetyl group that is attached to the nitrogen atom. This compound is sold as a dietary supplement commonly claiming antioxidant and liver protecting effects.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Alvirez-Freites EJ, et al. Antimicrob Agents Chemother, 2002, 46(4), 1022-1025.
[2] Tsai, J.C., et al. 1996. J. Biol. Chem. 271: 3667-3670.
[3] Tirouvanziam, R., et al. 2006. Proc. Natl. Acad. Sci. U.S.A. 103: 4628-4633.
[4] Ortolani, O., et al. 2000. Am. J. Respir. Crit. Care Med. 161: 1907-1911.
分子式 C5H9NO3S |
分子量 163.19 |
CAS号 616-91-1 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO >30 mg/mL |
Water >30 mg/mL |
Ethanol >20 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02124525 | Tobacco Smoking|Oxidative Stress|Inflammation | Drug: N-acetylcysteine | Universidade Estadual de Londrina | Phase 3 | 2013-02-01 | 2014-04-24 |
NCT02865629 | Depression | Drug: N-acetyl cysteine | University of Cincinnati | 2016-08-01 | 2017-03-21 | |
NCT01808521 | Purpura, Thrombotic Thrombocytopenic|TTP | Drug: N-Acetylcysteine | Bloodworks (Puget Sound Blood Center)|University of Washington | Early Phase 1 | 2013-05-01 | 2016-10-14 |
NCT01403506 | Disorder Related to Renal Transplantation | Drug: N-acetyl Cysteine | Shahid Beheshti University of Medical Sciences | Phase 3 | 2011-04-01 | 2011-07-26 |
NCT00967005 | Gambling|Tobacco Use Disorder | Drug: N Acetyl Cysteine|Other: Sugar Pill | Yale University|National Institute on Drug Abuse (NIDA)|University of Minnesota - Clinical and Translational Science Institute | Phase 2 | 2009-09-01 | 2014-03-10 |
NCT00998972 | Brain Death|Chronic Renal Insufficiency | Drug: N-acetylcysteine | Institut d'Anesthesiologie des Alpes Maritimes | Phase 3 | 2006-09-01 | 2011-07-09 |
NCT00532688 | Heart Failure, Congestive|Kidney Failure, Chronic | Drug: N-acetylcysteine | Bayside Health|The Alfred | Phase 2|Phase 3 | 2007-09-01 | 2007-09-19 |
NCT02505477 | Schizophrenia|Cognitive Deficits|Schizophrenia; Negative Type | Drug: N-acetylcysteine|Other: Treatment as Usual | University of California, Los Angeles | Phase 4 | 2017-02-06 | 2017-02-08 |
NCT01866644 | Unspecified Complication of Liver Transplant | Drug: N-acetylcysteine|Drug: Saline | Instituto de Investigacion Sanitaria La Fe | Phase 3 | 2011-09-01 | 2015-07-21 |
NCT00896025 | Acute Liver Failure|Fulminant Hepatic Failure | Drug: N-acetylcysteine | William Lee|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|University of Texas Southwestern Medical Center | Phase 4 | 2008-12-01 | 2014-01-29 |
NCT00637624 | Carcinoma, Non-Small-Cell Lung|Carcinoma, Small Cell Lung|Mesothelioma | Drug: N-Acetylcysteine|Drug: Placebo | Rijnstate Hospital | 2008-03-01 | 2011-08-08 | |
NCT02212678 | Parkinson Disease | Drug: N-acetylcysteine capsule | University of Minnesota - Clinical and Translational Science Institute|Parkinson's Disease Society of the United Kingdom | Phase 2 | 2014-09-01 | 2016-02-17 |
NCT00568087 | Alcoholism | Drug: N-acetylcysteine|Drug: Placebo | Minneapolis Veterans Affairs Medical Center|Minnesota Veterans Medical Research and Education Foundation | Phase 1|Phase 2 | 2007-12-01 | 2013-08-28 |
NCT00248625 | Acute Liver Failure|Hepatic Encephalopathy | Drug: N-acetylcysteine|Drug: Placebo | University of Pittsburgh|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Phase 3 | 2000-01-01 | 2016-06-16 |
NCT01118663 | Acetaminophen Overdose | Drug: Acetadote EF (Ethylenediaminetetraacetic Acid (EDTA) - Free)|Drug: Acetadote | Cumberland Pharmaceuticals | Phase 3 | 2010-09-01 | 2014-08-01 |
NCT01726465 | Ischemic Reperfusion Injury|Insufficiency; Hepatic, Postoperative|Liver Tumour | Drug: Methylprednisolone|Drug: N-acetylcysteine | Istituto Clinico Humanitas | Phase 2 | 2012-11-01 | 2013-11-09 |
NCT02788292 | Adipose Tissue Atrophy|Deformity of Reconstructed Breast|Graft Loss | Drug: Acetylcysteine | Michael Bezuhly|Nova Scotia Health Authority | Phase 4 | 2016-07-01 | 2016-05-27 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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