Abiraterone

阿比特龙,CB-7598,CB7598,CB 7598,

Abiraterone是一种有效的类固醇细胞色素P450 17alpha-羟化酶-17, 20-裂解酶(CYP17)抑制剂,IC50为2 nM;对前列腺癌有活性。

目录号
EY1507
EY1507
EY1507
EY1507
纯度
99.09%
99.09%
99.09%
99.09%
规格
1 mg
5 mg
25 mg
100 mg
原价
120
280
800
1900
售价
120
280
800
1900
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Abiraterone (CB-7598) is a potent steroidal cytochrome P450 17alpha-hydroxylase-17,20-lyase (CYP17) inhibitor with an IC50 at 4 nM. Abiraterone is used in treatment of prostate cancer.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

    0.1 μM, 1 μM, -5 μM

  • 动物实验

    0.15 mmol/kg皮下注射

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Attard G, et al. J Clin Oncol. 2008, 26(28), 4563-4571.

    分子式
    C24H31NO
    分子量
    349.51
    CAS号
    154229-19-3
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    <1 mg/mL
    Water
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02426333 Metastatic Castration Resistant Prostate Cancer Other: Abiraterone Acetate Radboud University|Janssen-Cilag Ltd. Phase 1|Phase 2 2015-05-01 2016-09-15
    NCT01961843 Prostate Cancer Drug: Abiraterone|Drug: Prednisone Massachusetts General Hospital 2013-10-01 2017-03-16
    NCT01735396 Prostate Cancer Drug: Abiraterone Acetate Icahn School of Medicine at Mount Sinai Phase 2 2012-12-01 2017-01-09
    NCT01199146 Prostate Cancer Drug: Abiraterone acetate University of California, San Francisco|Johnson & Johnson|Cougar Biotechnology, Inc. Phase 2 2010-09-01 2015-10-02
    NCT02656615 Prostate Cancer Drug: abiraterone acetate Aurelius Omlin|Cantonal Hospital of St. Gallen|University Hospital, Basel, Switzerland Phase 2 2016-01-01 2017-03-22
    NCT01495910 21-hydroxylase Deficiency Drug: Abiraterone acetate Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Phase 1 2011-12-01 2014-02-27
    NCT02787837 Prostate Cancer Drug: Abiraterone Centro Nacional de Investigaciones Oncologicas CARLOS III 2014-05-01 2017-03-07
    NCT02415621 Prostate Cancer Drug: Abiraterone Acetate H. Lee Moffitt Cancer Center and Research Institute 2015-04-01 2017-02-06
    NCT01655147 Healthy Drug: Abiraterone acetate|Drug: Rifampicin Janssen Research & Development, LLC Phase 1 2012-01-01 2013-01-08
    NCT01842321 Breast Cancer Drug: Abiraterone Acetate UNICANCER Phase 2 2013-07-01 2016-03-17
    NCT01637402 Castration Resistant Prostate Cancer Drug: Abiraterone Acetate|Drug: Prednisone Terence Friedlander, MD|Janssen, LP|University of California, San Francisco Phase 2 2013-03-01 2016-05-20
    NCT02867852 Salivary Glands Tumors Drug: Abiraterone acetate Fondazione IRCCS Istituto Nazionale dei Tumori, Milano Phase 2 2015-03-01 2016-08-22
    NCT02608359 Prostate Cancer Drug: Abiraterone Acetate Johnson & Johnson Private Limited 2016-05-31 2017-03-12
    NCT02125357 Metastatic Castration-Resistant Prostate Cancer Drug: Abiraterone acetate|Drug: Enzalutamide British Columbia Cancer Agency Phase 2 2014-09-01 2017-02-01
    NCT01940276 Prostate Cancer Drug: Abiraterone acetate|Drug: Prednisone Duke University Phase 2 2013-10-01 2016-10-21
    NCT01780220 Biochemically-relapsing Prostate Adenocarcinoma Following Radical Prostatectomy Drug: Abiraterone UNICANCER Phase 1|Phase 2 2012-12-01 2013-01-29
    NCT01424930 Prostate Neoplasms|Prostate Cancer Drug: Abiraterone|Drug: Prednisone Janssen-Ortho Inc., Canada Phase 2 2011-10-01 2014-07-14
    NCT00910754 Prostate Neoplasms Drug: Abiraterone acetate|Drug: Prednisone Janssen Research & Development, LLC Phase 1 2009-05-01 2013-04-11
    NCT02001571 Prostate Cancer Drug: Abiraterone acetate Cougar Biotechnology, Inc. Phase 1 2009-08-01 2013-11-28
    NCT01678573 Healthy Drug: Treatment A: abiraterone acetate|Drug: Treatment B: abiraterone acetate|Drug: Treatment C: abiraterone acetate Janssen Research & Development, LLC Phase 1 2012-07-01 2013-09-05

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

  • 相关化合物库

  • 使用AMQUAR产品发表文献后请联系我们

相关推荐

X
  • 联系人 :
  • 收件地址 :
  • 电话号码 :
  • 单位名称 :
  • 产品货号 :
  • 产品规格 :
  • 发票抬头以及单位税号 :