Abiraterone是一种有效的类固醇细胞色素P450 17alpha-羟化酶-17, 20-裂解酶(CYP17)抑制剂,IC50为2 nM;对前列腺癌有活性。
Abiraterone (CB-7598) is a potent steroidal cytochrome P450 17alpha-hydroxylase-17,20-lyase (CYP17) inhibitor with an IC50 at 4 nM. Abiraterone is used in treatment of prostate cancer.
0.1 μM, 1 μM, -5 μM
0.15 mmol/kg皮下注射
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Attard G, et al. J Clin Oncol. 2008, 26(28), 4563-4571.
分子式 C24H31NO |
分子量 349.51 |
CAS号 154229-19-3 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO <1 mg/mL |
Water |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02426333 | Metastatic Castration Resistant Prostate Cancer | Other: Abiraterone Acetate | Radboud University|Janssen-Cilag Ltd. | Phase 1|Phase 2 | 2015-05-01 | 2016-09-15 |
NCT01961843 | Prostate Cancer | Drug: Abiraterone|Drug: Prednisone | Massachusetts General Hospital | 2013-10-01 | 2017-03-16 | |
NCT01735396 | Prostate Cancer | Drug: Abiraterone Acetate | Icahn School of Medicine at Mount Sinai | Phase 2 | 2012-12-01 | 2017-01-09 |
NCT01199146 | Prostate Cancer | Drug: Abiraterone acetate | University of California, San Francisco|Johnson & Johnson|Cougar Biotechnology, Inc. | Phase 2 | 2010-09-01 | 2015-10-02 |
NCT02656615 | Prostate Cancer | Drug: abiraterone acetate | Aurelius Omlin|Cantonal Hospital of St. Gallen|University Hospital, Basel, Switzerland | Phase 2 | 2016-01-01 | 2017-03-22 |
NCT01495910 | 21-hydroxylase Deficiency | Drug: Abiraterone acetate | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Phase 1 | 2011-12-01 | 2014-02-27 |
NCT02787837 | Prostate Cancer | Drug: Abiraterone | Centro Nacional de Investigaciones Oncologicas CARLOS III | 2014-05-01 | 2017-03-07 | |
NCT02415621 | Prostate Cancer | Drug: Abiraterone Acetate | H. Lee Moffitt Cancer Center and Research Institute | 2015-04-01 | 2017-02-06 | |
NCT01655147 | Healthy | Drug: Abiraterone acetate|Drug: Rifampicin | Janssen Research & Development, LLC | Phase 1 | 2012-01-01 | 2013-01-08 |
NCT01842321 | Breast Cancer | Drug: Abiraterone Acetate | UNICANCER | Phase 2 | 2013-07-01 | 2016-03-17 |
NCT01637402 | Castration Resistant Prostate Cancer | Drug: Abiraterone Acetate|Drug: Prednisone | Terence Friedlander, MD|Janssen, LP|University of California, San Francisco | Phase 2 | 2013-03-01 | 2016-05-20 |
NCT02867852 | Salivary Glands Tumors | Drug: Abiraterone acetate | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | Phase 2 | 2015-03-01 | 2016-08-22 |
NCT02608359 | Prostate Cancer | Drug: Abiraterone Acetate | Johnson & Johnson Private Limited | 2016-05-31 | 2017-03-12 | |
NCT02125357 | Metastatic Castration-Resistant Prostate Cancer | Drug: Abiraterone acetate|Drug: Enzalutamide | British Columbia Cancer Agency | Phase 2 | 2014-09-01 | 2017-02-01 |
NCT01940276 | Prostate Cancer | Drug: Abiraterone acetate|Drug: Prednisone | Duke University | Phase 2 | 2013-10-01 | 2016-10-21 |
NCT01780220 | Biochemically-relapsing Prostate Adenocarcinoma Following Radical Prostatectomy | Drug: Abiraterone | UNICANCER | Phase 1|Phase 2 | 2012-12-01 | 2013-01-29 |
NCT01424930 | Prostate Neoplasms|Prostate Cancer | Drug: Abiraterone|Drug: Prednisone | Janssen-Ortho Inc., Canada | Phase 2 | 2011-10-01 | 2014-07-14 |
NCT00910754 | Prostate Neoplasms | Drug: Abiraterone acetate|Drug: Prednisone | Janssen Research & Development, LLC | Phase 1 | 2009-05-01 | 2013-04-11 |
NCT02001571 | Prostate Cancer | Drug: Abiraterone acetate | Cougar Biotechnology, Inc. | Phase 1 | 2009-08-01 | 2013-11-28 |
NCT01678573 | Healthy | Drug: Treatment A: abiraterone acetate|Drug: Treatment B: abiraterone acetate|Drug: Treatment C: abiraterone acetate | Janssen Research & Development, LLC | Phase 1 | 2012-07-01 | 2013-09-05 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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