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Cyclophosphamide Monohydrate

一水环磷酰胺

Cyclophosphamide monohydrate是一种氮芥类烷化剂,使烷基连接到DNA的鸟嘌呤碱基。

目录号
EY1492
EY1492
EY1492
纯度
99.27%
99.27%
99.27%
规格
50 mg
100 mg
500 mg
原价
180
320
600
售价
180
320
600
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Cyclophosphamide is a nitrogen mustard alkylating agent used in the treatment of cancers and autoimmune disorders.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Lutsiak ME, et al. Blood, 2005, 105(7), 2862-2868.
    [2] Lee, J.H., et al. 1997. J. Korean Med. Sci. 12: 185-189.
    [3] Wang, G.J. and Cai, L. 1999. Mutat. Res. 427: 125-133.

    分子式
    C7H15Cl2N2O2P.H2O
    分子量
    279.1
    CAS号
    6055-19-2
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    50 mg/mL
    Water
    9 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02139280 Hematologic Malignancies Drug: Cyclophosphamide Dartmouth-Hitchcock Medical Center Phase 2 2013-12-01 2016-11-02
    NCT00501995 Scleroderma Drug: IV Cyclophosphamide Johns Hopkins University Phase 3 2001-02-01 2016-08-29
    NCT01836289 Crohn's Disease|Crohn Disease Drug: High-dose Cyclophosphamide Johns Hopkins University Phase 1|Phase 2 2015-03-01 2015-03-01
    NCT01630538 Antibody Mediated Rejection Drug: Cyclophosphamide University of Manitoba Phase 2 2013-06-01 2016-10-24
    NCT02389309 Solid Tumors Drug: Dasatinib|Drug: Cyclophosphamide|Drug: Temsirolimus M.D. Anderson Cancer Center Phase 1 2015-10-05 2017-03-07
    NCT00412243 Burkitt's Lymphoma|Lymphoblastic Lymphoma|Acute Lymphoblastic Leukemia Drug: Clofarabine|Drug: Cyclophosphamide M.D. Anderson Cancer Center|Genzyme, a Sanofi Company Phase 1|Phase 2 2006-03-01 2013-03-08
    NCT02444091 Chronic Fatigue Syndrome (CFS)|Myalgic Encephalomyelitis (ME) Drug: Cyclophosphamide Haukeland University Hospital|The Kavli Foundation|Oslo University Hospital Phase 2 2015-03-01 2016-04-11
    NCT01352338 Multiple Myeloma Drug: Lenalidomide, endoxan, prednisone|Drug: lenalidomide, endoxan, prednisone UMC Utrecht|Celgene Corporation Phase 1|Phase 2 2011-08-01 2016-02-25
    NCT00981708 Amyloidosis Drug: Lenalidomide, Dexamethasone and Cyclophosphamide University of Athens|Hellenic Cooperative Oncology Group Phase 1|Phase 2 2008-02-01 2014-01-30
    NCT01974518 Pemphigus Drug: Rituximab and Cyclophosphamide IV Uprety Shraddha|Postgraduate Institute of Medical Education and Research Phase 3 2013-11-01 2014-10-29
    NCT02794077 Recurrent Nasopharyngeal Undifferentiated Carcinoma|Stage IV Nasopharyngeal Undifferentiated Carcinoma Drug: Cyclophosphamide The University of Hong Kong Phase 2 2008-01-01 2016-06-02
    NCT01995331 Aplastic Anemia Drug: cyclophosphamide,cyclosporine A Xiaofan Zhu|Chinese Academy of Medical Sciences Phase 4 2012-03-01 2013-11-21
    NCT02013336 Recurrent or Refractory Solid Tumors|Ewing Sarcoma|Rhabdomyosarcoma|Neuroblastoma|Osteosarcoma Drug: MM-398 (Irinotecan Sucrosofate Liposome Injection) plus cyclophosphamide South Plains Oncology Consortium Phase 1 2013-12-01 2017-02-02
    NCT00890955 Lung Cancer Drug: Amrubicin|Drug: Cyclophosphamide Lawrence Einhorn|Celgene Corporation|Hoosier Cancer Research Network Phase 1 2009-03-01 2015-12-21
    NCT01207297 SLE|Lupus Nephritis|Renal Insufficiency|End-stage Renal Disease Drug: Tacrolimus|Drug: cyclophosphamide Zhejiang University Phase 1 2003-03-01 2011-08-22
    NCT01740401 Melanoma Drug: Cyclophosphamide, Ipilimumab Icahn School of Medicine at Mount Sinai|Bristol-Myers Squibb Phase 2 2012-10-01 2015-01-06
    NCT01910844 Metastatic Breast Cancer Drug: Cisplatin|Drug: Cyclophosphamide Centre Jean Perrin Phase 2 2013-07-01 2016-10-10
    NCT02441491 ROHHAD Syndrome Drug: Cyclophosphamide Sidney Kimmel Comprehensive Cancer Center 2015-03-01 2016-05-17
    NCT00176605 Prostate Cancer Drug: Etoposide|Drug: Cyclophosphamide Rutgers, The State University of New Jersey|National Cancer Institute (NCI)|Bristol-Myers Squibb Phase 2 2005-05-01 2014-04-18
    NCT00844506 Ovarian Cancer Drug: P53-SLP vaccine|Drug: Cyclophosphamide University Medical Center Groningen|ISA Pharmaceuticals B.V.|Dutch Cancer Society Phase 2 2008-10-01 2011-02-24

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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