Home > NRTIs & > Zidovudine

Zidovudine

齐多呋定,叠氮胸苷,Azidothymidine, NSC 602670, AZT

Zidovudine是核苷类似物逆转录酶抑制剂（NRTI），可作用于HIV/AIDS感染。

目录号
EY1481
EY1481
纯度
99.51%
99.51%
规格
100 mg
500 mg
原价
590
1400
售价
590
1400
库存
现货
现货
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  • 生物活性

    Zidovudine (ZDV) is a nucleoside analogue reverse transcriptase inhibitor, used to treat HIV.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Chiang G, et al. Clin Ther,?996, 18(6), 1080-1092.
    [2] Broder (2010) The development of antiretroviral therapy and its impact on the HIV-1/AIDS pandemic. Antiviral Res. 85 1.
    [3] Pereira et al (2013) Azidothymidine is effective against human multiple myeloma: a new use for an old drug? Anticancer Agents Med.Chem. 13 186.
    [4] Yu et al (2015) Small molecules enhance CRISPR genome editing in pluripotent stem cells. Cell Stem Cell 16 142.

    分子式
    C10H13N5O4    		 分子量
    267.24    		 CAS号
    30516-87-1    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    50 mg/mL    		 Water
    50 mg/mL    		 Ethanol
    20 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01540240 HIV|Zidovudine Adverse Reaction Drug: Zidovudine|Drug: Zidovudine University Hospital, Geneva Phase 2|Phase 3 2011-08-01 2012-02-27
    NCT00000765 HIV Infections Drug: Zidovudine National Institute of Allergy and Infectious Diseases (NIAID)|Glaxo Wellcome null 2012-03-15
    NCT00324649 HIV-1 Drug: Truvada|Drug: Zidovudine/lamivudine Gilead Sciences Phase 4 2006-05-01 2015-08-13
    NCT00000983 HIV Infections Drug: Zidovudine National Institute of Allergy and Infectious Diseases (NIAID)|Glaxo Wellcome Phase 2 null 2012-03-15
    NCT00000736 HIV Infections Drug: Zidovudine National Institute of Allergy and Infectious Diseases (NIAID) Phase 3 null 2012-03-15
    NCT00779376 Healthy Drug: Zidovudine 300mg tablets Ranbaxy Laboratories Limited|Ranbaxy Inc. 2005-02-01 2008-10-23
    NCT00001011 HIV Infections Drug: Zidovudine National Institute of Allergy and Infectious Diseases (NIAID) Phase 3 null 2012-03-15
    NCT00779233 Healthy Drug: Zidovudine tablets 300 mg Ranbaxy Laboratories Limited|Ranbaxy Inc. 2004-09-01 2008-10-23
    NCT00000999 HIV Infections Drug: Zidovudine National Institute of Allergy and Infectious Diseases (NIAID) Phase 1 null 2012-03-15
    NCT00000750 HIV Infections Drug: Zidovudine National Institute of Allergy and Infectious Diseases (NIAID)|Glaxo Wellcome Phase 3 null 2012-03-15
    NCT00000990 HIV Infections Drug: Zidovudine National Institute of Allergy and Infectious Diseases (NIAID) Phase 2 null 2012-03-15
    NCT00000662 HIV Infections Drug: Zidovudine National Institute of Allergy and Infectious Diseases (NIAID)|Glaxo Wellcome null 2016-10-27
    NCT00100568 HIV Infections Drug: Efavirenz|Drug: Lamivudine/zidovudine National Institute of Allergy and Infectious Diseases (NIAID)|Initiative Senegalaise d'Acces aux Antiretroviraux (ISAARV) 2006-07-01 2013-09-04
    NCT00000629 HIV Infections Drug: Valproic acid|Drug: Zidovudine National Institute of Allergy and Infectious Diseases (NIAID) Phase 1 null 2008-07-29
    NCT00000709 AIDS Dementia Complex|HIV Infections Drug: Zidovudine National Institute of Allergy and Infectious Diseases (NIAID) Phase 3 null 2012-03-15
    NCT00000685 HIV Infections|Kidney Disease Drug: Zidovudine National Institute of Allergy and Infectious Diseases (NIAID) Phase 1 null 2012-03-15
    NCT00000979 HIV Infections Drug: Zidovudine|Drug: Didanosine National Institute of Allergy and Infectious Diseases (NIAID)|Bristol-Myers Squibb Phase 2 null 2011-03-11
    NCT00002307 HIV Infections Drug: Stavudine|Drug: Zidovudine Bristol-Myers Squibb null 2011-08-04
    NCT00000965 HIV Infections Drug: Zidovudine National Institute of Allergy and Infectious Diseases (NIAID)|Glaxo Wellcome null 2011-02-25
    NCT00001106 HIV Infections|Pregnancy Drug: Zidovudine National Institute of Allergy and Infectious Diseases (NIAID) Phase 1 null 2015-06-02
    NCT00470041 Healthy Drug: administration of two anti-viral drugs (lamivudine and zidovudine) from a new oral formulation University Ghent Phase 1 2007-06-01 2010-06-15
    NCT00000671 HIV Infections Drug: Zidovudine|Drug: Didanosine National Institute of Allergy and Infectious Diseases (NIAID)|Bristol-Myers Squibb Phase 2 null 2011-03-11
    NCT00000993 HIV Infections Drug: Zidovudine National Institute of Allergy and Infectious Diseases (NIAID) null 2016-11-04

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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