Nimodipine是钙离子通道阻断剂nifedipine类似物,能降血压,降低胞内游离钙,Beclin-1和自吞噬。
Nimodipine is a dihydropyridine calcium channel blocker and an autophagy inhibitor, used in the treatment of high blood pressure.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Moyer JR Jr, et al. J Neurophysiol,1992, 68(6), 2100-2109.
[2] Batuecas et al (1998) Effects of chronic nimodipine on working memory of old rats in relation to defects in synaptosomal calcium homeostasis. Eur.J.Pharmacol. 350 141.
[3] McCarthy, R.T., et al. 1992. J. Neurosci. 12: 2225-2234.
[4] Fleming et al (2011) Chemical modulators of autophagy as biological probes and potential therapeutics. Nat.Chem.Biol. 7 9.
[5] Izquierdo (1990) Nimodipine and the recovery of memory. TiPS 11 309.
[6] Dolin, S.J., et al. 1988. Eur. J. Pharmacol. 152: 19-27.
分子式 C21H26N2O7 |
分子量 418.44 |
CAS号 66085-59-4 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO >20 mg/mL |
Water <1 mg/mL |
Ethanol 10 mM |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01551368 | Infertility | Drug: Nimodipine|Drug: Placebo | Mount Sinai Hospital, Canada | Phase 2 | 2012-12-01 | 2016-05-04 |
NCT01835665 | Progranulin Mutation Carriers | Drug: Nimodipine | University of California, San Francisco|The Bluefield Project | Phase 1 | 2013-03-01 | 2016-05-12 |
NCT02790632 | Subarachnoid Hemorrhage, Aneurysmal | Drug: EG-1962 (nimodipine microparticles)|Drug: Enteral Nimodipine | Edge Therapeutics Inc | Phase 3 | 2016-07-01 | 2017-02-27 |
NCT02537080 | Mild Cognitive Impairment | Drug: Nimodipine group|Drug: Control group | University Hospital Hradec Kralove | 2015-09-01 | 2016-10-15 | |
NCT01672801 | Unexplained Infertility|Polycystic Ovarian Syndrome|Anovulatory | Drug: Placebo|Drug: Nimodipine | Boston IVF|Village Fertility Pharmacy | 2012-09-01 | 2016-01-11 | |
NCT02248233 | Cerebral Infarction | Drug: Nimodipine|Drug: Saline + citicoline | Fengtian Hospital | Phase 4 | 2014-10-01 | 2014-10-14 |
NCT01893190 | Ruptured Cerebral Aneurysm|Ruptured Berry Aneurysm | Drug: Nimodipine|Drug: Nimodipine Microparticles | Edge Therapeutics Inc | Phase 1|Phase 2 | 2013-09-01 | 2016-01-19 |
NCT00781326 | Depression | Drug: Nimodipine|Drug: Placebo | University of Pittsburgh|National Institute of Mental Health (NIMH) | Phase 4 | 2008-08-01 | 2016-08-05 |
NCT02893826 | Subarachnoid Hemorrhage, Aneurysmal | Drug: EG-1962 (nimodipine microparticles)|Drug: Enteral Nimodipine | Edge Therapeutics Inc | Phase 1 | 2016-09-01 | 2017-03-24 |
NCT00000332 | Cocaine-Related Disorders | Drug: Nimodipine | National Institute on Drug Abuse (NIDA)|Washington D.C. Veterans Affairs Medical Center | Phase 2 | 1998-05-01 | 2017-02-23 |
NCT00000738 | AIDS Dementia Complex|HIV Infections | Drug: Nimodipine|Drug: Zidovudine | National Institute of Allergy and Infectious Diseases (NIAID)|Miles|Glaxo Wellcome | Phase 1 | null | 2012-03-30 |
NCT02991157 | Subarachnoid Hemorrhage, Aneurysmal | Drug: Nimodipine | National Institute of Mental Health and Neuro Sciences, India | 2016-12-01 | 2016-12-09 | |
NCT03028090 | Indication for Peripheral Intravenous Catheterization | Device: SHERLOCK 3CG鈩?Tip Confirmation System with MODUS Software | C. R. Bard | 2013-11-01 | 2017-01-18 | |
NCT00004399 | Pre-eclampsia | Drug: magnesium sulfate|Drug: nimodipine | FDA Office of Orphan Products Development|University of Utah | 1995-09-01 | 2015-03-24 | |
NCT02165644 | Acute Cerebrovascular Accident|Vasospasm | Drug: Acetazolamide|Drug: Nimodipine | University of Florida | Phase 2 | 2015-09-01 | 2015-09-23 |
NCT00814658 | Dementia | Drug: Galantamine|Drug: Nimodipine|Drug: Placebo | Janssen-Cilag Farmaceutica Ltda. | Phase 4 | 2008-06-01 | 2013-08-22 |
NCT00000280 | Cocaine-Related Disorders | Drug: Nimodipine | Yale University|National Institute on Drug Abuse (NIDA)|VA Connecticut Healthcare System | Phase 1 | 1994-09-01 | 2013-07-24 |
NCT02983396 | Chest Pain|ST Elevation Myocardial Infarction | Device: Diagnostic accuracy of Mini Relf Device | University Ghent | 2016-11-01 | 2016-12-01 | |
NCT00317213 | Smoking | Drug: LIBERTAL- a phospholipid mixture | Kaplan Medical Center|Modus Biological Membranes, Ltd. | Phase 2 | 2002-02-01 | 2008-04-09 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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