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Nimodipine

尼莫地平,BAY E 9736,Nimotop,Periplum,Admon

Nimodipine是钙离子通道阻断剂nifedipine类似物,能降血压,降低胞内游离钙,Beclin-1和自吞噬。

目录号
EY1480
EY1480
纯度
99.15%
99.15%
规格
100 mg
500 mg
原价
360
756
售价
360
756
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Nimodipine is a dihydropyridine calcium channel blocker and an autophagy inhibitor, used in the treatment of high blood pressure.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Moyer JR Jr, et al. J Neurophysiol,1992, 68(6), 2100-2109.
    [2] Batuecas et al (1998) Effects of chronic nimodipine on working memory of old rats in relation to defects in synaptosomal calcium homeostasis. Eur.J.Pharmacol. 350 141.
    [3] McCarthy, R.T., et al. 1992. J. Neurosci. 12: 2225-2234.
    [4] Fleming et al (2011) Chemical modulators of autophagy as biological probes and potential therapeutics. Nat.Chem.Biol. 7 9.
    [5] Izquierdo (1990) Nimodipine and the recovery of memory. TiPS 11 309.
    [6] Dolin, S.J., et al. 1988. Eur. J. Pharmacol. 152: 19-27.

    分子式
    C21H26N2O7
    分子量
    418.44
    CAS号
    66085-59-4
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    >20 mg/mL
    Water
    <1 mg/mL
    Ethanol
    10 mM

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01551368 Infertility Drug: Nimodipine|Drug: Placebo Mount Sinai Hospital, Canada Phase 2 2012-12-01 2016-05-04
    NCT01835665 Progranulin Mutation Carriers Drug: Nimodipine University of California, San Francisco|The Bluefield Project Phase 1 2013-03-01 2016-05-12
    NCT02790632 Subarachnoid Hemorrhage, Aneurysmal Drug: EG-1962 (nimodipine microparticles)|Drug: Enteral Nimodipine Edge Therapeutics Inc Phase 3 2016-07-01 2017-02-27
    NCT02537080 Mild Cognitive Impairment Drug: Nimodipine group|Drug: Control group University Hospital Hradec Kralove 2015-09-01 2016-10-15
    NCT01672801 Unexplained Infertility|Polycystic Ovarian Syndrome|Anovulatory Drug: Placebo|Drug: Nimodipine Boston IVF|Village Fertility Pharmacy 2012-09-01 2016-01-11
    NCT02248233 Cerebral Infarction Drug: Nimodipine|Drug: Saline + citicoline Fengtian Hospital Phase 4 2014-10-01 2014-10-14
    NCT01893190 Ruptured Cerebral Aneurysm|Ruptured Berry Aneurysm Drug: Nimodipine|Drug: Nimodipine Microparticles Edge Therapeutics Inc Phase 1|Phase 2 2013-09-01 2016-01-19
    NCT00781326 Depression Drug: Nimodipine|Drug: Placebo University of Pittsburgh|National Institute of Mental Health (NIMH) Phase 4 2008-08-01 2016-08-05
    NCT02893826 Subarachnoid Hemorrhage, Aneurysmal Drug: EG-1962 (nimodipine microparticles)|Drug: Enteral Nimodipine Edge Therapeutics Inc Phase 1 2016-09-01 2017-03-24
    NCT00000332 Cocaine-Related Disorders Drug: Nimodipine National Institute on Drug Abuse (NIDA)|Washington D.C. Veterans Affairs Medical Center Phase 2 1998-05-01 2017-02-23
    NCT00000738 AIDS Dementia Complex|HIV Infections Drug: Nimodipine|Drug: Zidovudine National Institute of Allergy and Infectious Diseases (NIAID)|Miles|Glaxo Wellcome Phase 1 null 2012-03-30
    NCT02991157 Subarachnoid Hemorrhage, Aneurysmal Drug: Nimodipine National Institute of Mental Health and Neuro Sciences, India 2016-12-01 2016-12-09
    NCT03028090 Indication for Peripheral Intravenous Catheterization Device: SHERLOCK 3CG鈩?Tip Confirmation System with MODUS Software C. R. Bard 2013-11-01 2017-01-18
    NCT00004399 Pre-eclampsia Drug: magnesium sulfate|Drug: nimodipine FDA Office of Orphan Products Development|University of Utah 1995-09-01 2015-03-24
    NCT02165644 Acute Cerebrovascular Accident|Vasospasm Drug: Acetazolamide|Drug: Nimodipine University of Florida Phase 2 2015-09-01 2015-09-23
    NCT00814658 Dementia Drug: Galantamine|Drug: Nimodipine|Drug: Placebo Janssen-Cilag Farmaceutica Ltda. Phase 4 2008-06-01 2013-08-22
    NCT00000280 Cocaine-Related Disorders Drug: Nimodipine Yale University|National Institute on Drug Abuse (NIDA)|VA Connecticut Healthcare System Phase 1 1994-09-01 2013-07-24
    NCT02983396 Chest Pain|ST Elevation Myocardial Infarction Device: Diagnostic accuracy of Mini Relf Device University Ghent 2016-11-01 2016-12-01
    NCT00317213 Smoking Drug: LIBERTAL- a phospholipid mixture Kaplan Medical Center|Modus Biological Membranes, Ltd. Phase 2 2002-02-01 2008-04-09

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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