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生物活性
Blasticidin S HCl is an antibiotic inhibiting protein synthesis. In mouse leukemia L5178Y cells, blasticidin S inhibited protein synthesis and caused the degradation of presumptive mRNA. Also, blasticidin S inhibited ribonuclease P activity from Dictyostelium discoideum and inhibited tRNA maturation in a dose dependent way. In S. cerevisiae, blasticidin S inhibited protein synthesis induced by galactose. In Aspergillus parasiticus, blasticidin S inhibited aflatoxin production without inhibition of fungal growth. In Aspergillus flavus, blasticidin S significantly reduced aflatoxin biosynthetic enzymes. Blasticidin S efficiently bound Cu2+ ions and protected DNA from metal-induced damage. Blasticidin S enhanced the binding of tRNA to the P site of the large ribosomal subunit and slowed spontaneous intersubunit rotation. Blasticidin S inhibited peptide bond formation and peptidyl-tRNA hydrolysis.
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体外研究
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体内研究
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激酶实验
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细胞实验
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动物实验
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不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）
|  动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 |
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例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。
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参考文献
[1] Yamaguchi H, et al. J Biochem. 1966, 60(6), 632-642.
[2] Nishimura, M., et al. 2006. J. Biosci. Bioeng. 101: 63-69.
[3] Kimura, M., et al. 1994. Biochim. Biophys. Acta. 1219: 653-659.
分子式
C17H27ClN8O5 |
分子量
458.9 |
CAS号
3513-03-9 |
储存方式
﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂（常温）
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DMSO
<1 mg/mL |
Water
10 mM |
Ethanol
<1 mg/mL |
体内溶解度
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Clinical Trial Information ( data from http://clinicaltrials.gov )
注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。
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