| NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
| NCT00791531 | Malaria | Drug: Methotrexate | KEMRI-Wellcome Trust Collaborative Research Program|University of Oxford | Phase 1 | 2009-03-01 | 2012-04-23 |
| NCT02076997 | Cancer | Drug: Methotrexate | Baylor College of Medicine|Texas Children's Cancer Center | | 2013-12-01 | 2016-06-09 |
| NCT02037191 | ALOPECIA AREATA | Drug: Methotrexate|Drug: Placebo | University Hospital, Rouen | Phase 3 | 2014-02-01 | 2016-06-15 |
| NCT02940561 | Psoriasis|Rheumatoid Arthritis | Drug: Methotrexate - Amneal|Drug: Methotrexate - DAVA | Amneal Pharmaceuticals, LLC|Accutest Research Laboratories (I) Pvt. Ltd. | Phase 1 | 2016-08-01 | 2016-10-19 |
| NCT01884636 | Pharmacokinetics of Isavuconazole|Pharmacokinetics of Methotrexate|Pharmacokinetics of 7-hydroxymethotrexate|Healthy Subjects | Drug: isavuconazole|Drug: methotrexate | Astellas Pharma Global Development, Inc.|Basilea Pharmaceutica International Ltd|Astellas Pharma Inc | Phase 1 | 2013-02-01 | 2013-06-20 |
| NCT00779142 | Diabetic Macular Edema | Drug: Methotrexate intravenous 25mg/ml | Wake Forest University Health Sciences | | 2011-09-01 | 2014-06-27 |
| NCT00579644 | Rheumatoid Arthritis | Drug: Combination of Minocycline and MTX or MTX alone|Drug: methotrexate | University of Nebraska | Phase 3 | 2001-01-01 | 2010-01-12 |
| NCT00194272 | Ectopic Pregnancy | Drug: Methotrexate | University of Pennsylvania|Bill and Melinda Gates Foundation | Phase 3 | 2001-03-01 | 2011-08-08 |
| NCT02269358 | Crohn's Disease | Drug: METHOTREXATE | Prof. Arie Levine|Wolfson Medical Center | Phase 4 | 2015-07-01 | 2016-08-10 |
| NCT01633983 | Central Serous Chorioretinopathy | Drug: Methotrexate|Drug: Delayed treatment | Edward Averbukh|Hadassah Medical Organization | Phase 2 | 2012-08-01 | 2012-07-18 |
| NCT02124226 | Low Dose Methotrexate in Severe Chronic Asthma | Drug: Methotrexate|Drug: Placebo | Universita degli Studi di Catania | Phase 3 | 2017-02-01 | 2016-05-19 |
| NCT01162551 | Cancer|Leukemia|Lymphoma | Drug: Sirolimus and Methotrexate | Children's Hospital of Philadelphia|The Leukemia and Lymphoma Society | Phase 2 | 2010-05-01 | 2016-09-15 |
| NCT02714634 | Rheumatoid Arthritis|Insufficient Response to Methotrexate. | Drug: Methotrexate + biologic administration|Drug: methotrexate + salazopyrine + hydroxychloroquine administration | University Hospital, Strasbourg, France | Phase 4 | 2016-03-01 | 2016-03-15 |
| NCT02715947 | Psoriasis Vulgaris | Drug: Methotrexate | Central South University | Phase 2 | 2015-12-01 | 2016-03-21 |
| NCT02772965 | Pediatric Crohn's Disease | Drug: Methotrexate|Other: Sugar pill (placebo) | University of North Carolina, Chapel Hill|Patient-Centered Outcomes Research Institute|ImproveCareNow (ICN)|The Leona M. and Harry B. Helmsley Charitable Trust|Children's Hospital Medical Center, Cincinnati | Phase 3 | 2016-10-01 | 2016-12-02 |
| NCT00570817 | Methotrexate Induced Nephrotoxicity | Other: 12 hours of prehydration | University of Aarhus|ML J酶rgensen og Gunnar Hansens Foundation|Danish Child Cancer Foundation | | 2007-06-01 | 2011-11-04 |
| NCT00189878 | Urticaria | Drug: Methotrexate (drug)|Drug: placebo capsules | Barnsley Hospital | Phase 2 | 2003-08-01 | 2016-02-18 |
| NCT02644044 | To Evaluate the Effect of Therapy With IT MTX on the Disease Course of Patients With Progressive MS | Drug: Intrathecal methotrexate | Tel-Aviv Sourasky Medical Center | Early Phase 1 | 2016-01-01 | 2015-12-28 |
| NCT00905073 | Type 1 Diabetes Mellitus | Drug: cyclosporin and methotrexate | Georgetown University | | 1990-02-01 | 2011-04-12 |
| NCT01741558 | Myocardial Infarction | Drug: Methotrexate|Drug: Riboflavin | Instituto de Cardiologia do Rio Grande do Sul|Instituto de Cardiologia de Santa Catarina | Phase 2 | 2013-04-01 | 2013-04-05 |
