Hydroxychloroquine Sulfate是一种抗疟疾药,用于治疗系统性红斑狼疮,类风湿关节炎等自身免疫病,炎症以及皮肤病。它也是autophagy和toll-like receptor (TLR) 7/9的抑制剂。
Hydroxychloroquine Sulfate是一种抗疟疾药,用于治疗系统性红斑狼疮,类风湿关节炎等自身免疫病,炎症以及皮肤病。它也是autophagy和toll-like receptor (TLR) 7/9的抑制剂。
75 to 100 μM in human RCC cell lines
200 mg/kg in male Sprague Dawley (SD) rats
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Ramser B, et al.J Invest Dermatol, 2009,129(10):2419-26.
[2] Bourke L, et al. PLoS One. 2015, 10(12):e0143771.
[3] Marta Mosca, et al. 2013 ACR/ARHP Annual Meeting.
分子式 C18H28ClN3O5S |
分子量 433.95 |
CAS号 747-36-4 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO <1 mg/mL |
Water 100 mM |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02414776 | Estrogen Receptor Positive Breast Cancer | Drug: hydroxychloroquine | Western Regional Medical Center | Phase 1 | 2014-07-01 | 2015-04-07 |
NCT02874287 | Coronary Artery Disease | Drug: Hydroxychloroquine Sulfate Tablets|Drug: Placebo Tablets | First Affiliated Hospital Xi'an Jiaotong University | Phase 4 | 2016-08-01 | 2016-08-16 |
NCT01760421 | Hashimoto Thyroiditis | Drug: Hydroxychloroquine | National Taiwan University Hospital | 2011-10-01 | 2014-04-22 | |
NCT01687179 | Lymphangioleiomyomatosis | Drug: sirolimus and hydroxychloroquine | Brigham and Women's Hospital|National Heart, Lung, and Blood Institute (NHLBI) | Phase 1 | 2012-09-01 | 2016-08-11 |
NCT02126683 | Hashimoto's Thyroiditis | Drug: Hydroxychloroquine | National Taiwan University Hospital | 2014-04-01 | 2014-04-28 | |
NCT02351752 | Primary IgA Nephropathy | Drug: Hydroxychloroquine Sulfate | LLiu|Peking University First Hospital | Phase 4 | 2015-01-01 | 2015-12-15 |
NCT01144169 | Renal Cell Carcinoma | Drug: Hydroxychloroquine (HC) | University of Pittsburgh|National Institutes of Health (NIH) | Phase 1 | 2010-10-01 | 2016-10-24 |
NCT01273805 | Pancreatic Cancer | Drug: Hydroxychloroquine|Drug: Hydroxychloroquine | Dana-Farber Cancer Institute|Brigham and Women's Hospital|Massachusetts General Hospital | Phase 2 | 2010-12-01 | 2017-02-23 |
NCT00632866 | Primary Sj枚gren's Syndrome | Drug: Hydroxychloroquine|Drug: Placebo | Assistance Publique - H么pitaux de Paris|Sanofi | Phase 3 | 2008-03-01 | 2012-07-01 |
NCT00946790 | Immunosuppression|Rheumatism | Drug: Hydroxychloroquine Sulfate Tablets, 200 mg (Geneva Pharmaceutical, Inc.)|Drug: Hydroxychloroquine Sulfate Tablets, 200 mg, Plaquenil (Sanofi Winthrop) | Sandoz | Phase 1 | 1993-07-01 | 2009-07-24 |
NCT02765594 | Primary IgA Nephropathy | Drug: Hydroxychloroquine Sulfate|Drug: Valsartan | Peking Union Medical College Hospital | Phase 4 | 2016-05-01 | 2016-05-04 |
NCT01132118 | Rheumatoid Arthritis|Insulin Resistance | Drug: Hydroxychloroquine | Brigham and Women's Hospital|National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | Phase 3 | 2010-06-01 | 2014-09-02 |
NCT01266057 | Advanced Cancers | Drug: Hydroxychloroquine|Drug: Sirolimus|Drug: Vorinostat | M.D. Anderson Cancer Center | Phase 1 | 2011-04-01 | 2016-11-23 |
NCT00771056 | B-Cell Chronic Lymphocytic Leukemia | Drug: Hydroxychloroquine | Northwell Health | Phase 2 | 2008-07-01 | 2016-08-18 |
NCT01379573 | Congenital Heart Block|Neonatal Lupus|Autoantibody-Associated Heart Block | Drug: Hydroxychloroquine | New York University School of Medicine | Phase 2 | 2011-01-01 | 2016-09-21 |
NCT02913157 | Multiple Sclerosis, Primary Progressive | Drug: Hydroxychloroquine | University of Calgary | Phase 2 | 2016-11-01 | 2017-01-27 |
NCT01601028 | Autoimmune Diseases|Sjogren's Syndrome|Dry Eye | Drug: Hydroxychloroquine|Drug: Placebo | Seoul National University Hospital | Phase 3 | 2011-07-01 | 2013-10-16 |
NCT00726596 | Prostate Cancer | Drug: hydroxychloroquine | Rutgers, The State University of New Jersey|Rutgers Cancer Institute of New Jersey|National Cancer Institute (NCI) | Phase 2 | 2008-08-01 | 2015-12-16 |
NCT01128296 | Pancreatic Cancer | Drug: Hydroxychloroquine|Drug: Gemcitabine | University of Pittsburgh|National Institutes of Health (NIH) | Phase 1|Phase 2 | 2010-10-01 | 2015-01-13 |
NCT02026232 | Type 2 Diabetes Mellitus | Drug: Hydroxychloroquine|Other: Hydroxychloroquine Placebo | Washington University School of Medicine | 2012-03-01 | 2016-10-31 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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