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Hydroxychloroquine Sulfate

硫酸羟基氯喹,硫酸羟氯喹

Hydroxychloroquine Sulfate是一种抗疟疾药,用于治疗系统性红斑狼疮,类风湿关节炎等自身免疫病,炎症以及皮肤病。它也是autophagy和toll-like receptor (TLR) 7/9的抑制剂。

目录号
EY1412
EY1412
EY1412
纯度
99.48%
99.48%
99.48%
规格
10 mg
50 mg
100 mg
原价
200
400
600
售价
200
400
600
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Hydroxychloroquine Sulfate是一种抗疟疾药,用于治疗系统性红斑狼疮,类风湿关节炎等自身免疫病,炎症以及皮肤病。它也是autophagy和toll-like receptor (TLR) 7/9的抑制剂。

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

    75 to 100 μM in human RCC cell lines

  • 动物实验

    200 mg/kg in male Sprague Dawley (SD) rats

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Ramser B, et al.J Invest Dermatol, 2009,129(10):2419-26.
    [2] Bourke L, et al. PLoS One. 2015, 10(12):e0143771.
    [3] Marta Mosca, et al. 2013 ACR/ARHP Annual Meeting.

    分子式
    C18H28ClN3O5S
    分子量
    433.95
    CAS号
    747-36-4
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    <1 mg/mL
    Water
    100 mM
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02414776 Estrogen Receptor Positive Breast Cancer Drug: hydroxychloroquine Western Regional Medical Center Phase 1 2014-07-01 2015-04-07
    NCT02874287 Coronary Artery Disease Drug: Hydroxychloroquine Sulfate Tablets|Drug: Placebo Tablets First Affiliated Hospital Xi'an Jiaotong University Phase 4 2016-08-01 2016-08-16
    NCT01760421 Hashimoto Thyroiditis Drug: Hydroxychloroquine National Taiwan University Hospital 2011-10-01 2014-04-22
    NCT01687179 Lymphangioleiomyomatosis Drug: sirolimus and hydroxychloroquine Brigham and Women's Hospital|National Heart, Lung, and Blood Institute (NHLBI) Phase 1 2012-09-01 2016-08-11
    NCT02126683 Hashimoto's Thyroiditis Drug: Hydroxychloroquine National Taiwan University Hospital 2014-04-01 2014-04-28
    NCT02351752 Primary IgA Nephropathy Drug: Hydroxychloroquine Sulfate LLiu|Peking University First Hospital Phase 4 2015-01-01 2015-12-15
    NCT01144169 Renal Cell Carcinoma Drug: Hydroxychloroquine (HC) University of Pittsburgh|National Institutes of Health (NIH) Phase 1 2010-10-01 2016-10-24
    NCT01273805 Pancreatic Cancer Drug: Hydroxychloroquine|Drug: Hydroxychloroquine Dana-Farber Cancer Institute|Brigham and Women's Hospital|Massachusetts General Hospital Phase 2 2010-12-01 2017-02-23
    NCT00632866 Primary Sj枚gren's Syndrome Drug: Hydroxychloroquine|Drug: Placebo Assistance Publique - H么pitaux de Paris|Sanofi Phase 3 2008-03-01 2012-07-01
    NCT00946790 Immunosuppression|Rheumatism Drug: Hydroxychloroquine Sulfate Tablets, 200 mg (Geneva Pharmaceutical, Inc.)|Drug: Hydroxychloroquine Sulfate Tablets, 200 mg, Plaquenil (Sanofi Winthrop) Sandoz Phase 1 1993-07-01 2009-07-24
    NCT02765594 Primary IgA Nephropathy Drug: Hydroxychloroquine Sulfate|Drug: Valsartan Peking Union Medical College Hospital Phase 4 2016-05-01 2016-05-04
    NCT01132118 Rheumatoid Arthritis|Insulin Resistance Drug: Hydroxychloroquine Brigham and Women's Hospital|National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Phase 3 2010-06-01 2014-09-02
    NCT01266057 Advanced Cancers Drug: Hydroxychloroquine|Drug: Sirolimus|Drug: Vorinostat M.D. Anderson Cancer Center Phase 1 2011-04-01 2016-11-23
    NCT00771056 B-Cell Chronic Lymphocytic Leukemia Drug: Hydroxychloroquine Northwell Health Phase 2 2008-07-01 2016-08-18
    NCT01379573 Congenital Heart Block|Neonatal Lupus|Autoantibody-Associated Heart Block Drug: Hydroxychloroquine New York University School of Medicine Phase 2 2011-01-01 2016-09-21
    NCT02913157 Multiple Sclerosis, Primary Progressive Drug: Hydroxychloroquine University of Calgary Phase 2 2016-11-01 2017-01-27
    NCT01601028 Autoimmune Diseases|Sjogren's Syndrome|Dry Eye Drug: Hydroxychloroquine|Drug: Placebo Seoul National University Hospital Phase 3 2011-07-01 2013-10-16
    NCT00726596 Prostate Cancer Drug: hydroxychloroquine Rutgers, The State University of New Jersey|Rutgers Cancer Institute of New Jersey|National Cancer Institute (NCI) Phase 2 2008-08-01 2015-12-16
    NCT01128296 Pancreatic Cancer Drug: Hydroxychloroquine|Drug: Gemcitabine University of Pittsburgh|National Institutes of Health (NIH) Phase 1|Phase 2 2010-10-01 2015-01-13
    NCT02026232 Type 2 Diabetes Mellitus Drug: Hydroxychloroquine|Other: Hydroxychloroquine Placebo Washington University School of Medicine 2012-03-01 2016-10-31

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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