Pioglitazone hydrochloride (盐酸吡格列酮; U 72107A; AD 4833) 是PPARγ刺激剂。
Pioglitazone HCl is a hydrochloride salt form of pioglitazone, which is an orally active, thiazoledinedione (TZD) and a highly selective PPAR-γ agonist. Pioglitazone is a selective hPPARgamma1 activator and a weak hPPARalpha activator. Binding assay indicated that the transactivation of hPPARgamma1 or hPPARalpha by pioglitazone is due to direct binding of pioglitazone to each subtype.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
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[2] Naito, Y., et al. 2001. Aliment. Pharmacol. Ther. 15: 865-873.
[3] Ishibashi, M., et al. 2002. Hypertension. 40: 687-693.
[4] Naito, Y. and Yoshikawa, T. 2004. Drugs Today. 40: 423-430.
分子式 C19H21ClN2O3S |
分子量 392.9 |
CAS号 112529-15-4 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 80 mg/mL |
Water <1 mg/mL |
Ethanol 5 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01873001 | Healthy Volunteers | Drug: Pioglitazone HCl|Drug: Abiraterone acetate | Janssen Research & Development, LLC | Phase 1 | 2013-05-01 | 2014-04-16 |
NCT00649012 | Healthy | Drug: Pioglitazone HCl Tablets 45 mg|Drug: Actos庐 Tablets 45 mg | Mylan Pharmaceuticals | Phase 1 | 2003-03-01 | 2008-03-31 |
NCT00649558 | Healthy | Drug: Pioglitazone HCl Tablets 45 mg|Drug: Actos庐 Tablets 45 mg | Mylan Pharmaceuticals | Phase 1 | 2003-02-01 | 2008-03-31 |
NCT00494559 | Diabetes Mellitus|Coronary Artery Stenosis | Drug: Pioglitazone|Drug: Placebo | Korea University Anam Hospital | Phase 4 | 2007-07-01 | 2016-02-24 |
NCT01090752 | Diabetes|Hypertension | Drug: Pioglitazone|Drug: Metformin | University Hospital, Geneva|University of Lausanne Hospitals | Phase 4 | 2005-10-01 | 2010-03-24 |
NCT03080480 | Chronic Granulomatous Disease | Drug: Pioglitazone | Children's Hospital of Fudan University | Phase 1|Phase 2 | 2017-04-01 | 2017-03-14 |
NCT00671515 | Depressive Disorder, Major|Metabolic Syndrome X | Drug: Pioglitazone | Joseph Calabrese, MD|Takeda Pharmaceuticals North America, Inc.|University Hospitals Cleveland Medical Center | Phase 2 | 2008-04-01 | 2016-11-30 |
NCT02697617 | Polycystic Kidney Disease | Drug: Pioglitazone|Drug: Placebo | Indiana University | Phase 2 | 2015-10-01 | 2016-10-13 |
NCT01151670 | Brain Neoplasms, Malignant|Brain Neoplasms, Benign|Malignant Meningioma|Glioblastoma Multiforme|Anaplastic Astrocytoma | Drug: pioglitazone|Drug: Pioglitazone | Wake Forest University Health Sciences | Phase 1 | 2010-08-01 | 2017-01-17 |
NCT02687425 | Leukemia, Myelogenous, Chronic, BCR-ABL Positive | Drug: Pioglitazone|Drug: imatinib mesylate | Meng Li|Tongji Hospital | Phase 2 | 2016-02-01 | 2016-02-16 |
NCT00719381 | Cystic Fibrosis | Drug: Pioglitazone | Paul Beringer|University of Southern California | Phase 1 | 2008-01-01 | 2012-06-13 |
NCT01637935 | Diabetes|Bladder Cancer | Drug: Pioglitazone | Takeda|Kaiser Permanente|Department of Epidemiology at University of Pennsylvania | 2004-07-01 | 2015-12-09 | |
NCT01352182 | Severe Sepsis|Septic Shock | Drug: Pioglitazone hydrochloride | Children's Hospital Medical Center, Cincinnati | Phase 1|Phase 2 | 2011-10-01 | 2017-01-05 |
NCT00672919 | Diabetes Mellitus | Drug: Pioglitazone | Takeda | Phase 4 | 2003-11-01 | 2012-02-27 |
NCT01931566 | Mild Cognitive Impairment Due to Alzheimer's Disease | Drug: Pioglitazone|Drug: Pioglitazone placebo | Takeda|Zinfandel Pharmaceuticals Inc. | Phase 3 | 2013-08-01 | 2017-01-31 |
NCT00835120 | Metabolic Syndrome|Bipolar Depression|Insulin Resistance | Drug: Pioglitazone | University Hospitals Cleveland Medical Center|National Alliance for Research on Schizophrenia and Depression|Takeda Pharmaceuticals North America, Inc. | Phase 4 | 2009-03-01 | 2016-11-30 |
NCT00845182 | Type 2 Diabetes|Healthy|Impaired Glucose Tolerance | Drug: Pioglitazone|Drug: Exenatide|Drug: Pioglitazone and Exenatide | The University of Texas Health Science Center at San Antonio | Phase 4 | 2007-06-01 | 2015-08-08 |
NCT00220961 | Impaired Glucose Tolerance|Type 2 Diabetes | Drug: Pioglitazone|Drug: Placebo | The University of Texas Health Science Center at San Antonio|University of Texas|Takeda Pharmaceuticals North America, Inc. | Phase 3 | 2004-01-01 | 2016-06-29 |
NCT02958956 | Diabetes Mellitus, Type 2, Cancer | Drug: Pioglitazone | Takeda | 1997-01-01 | 2016-11-12 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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