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Pioglitazone HCl

盐酸吡格列酮,AD-4833,U-72107E,U 72107A

Pioglitazone hydrochloride (盐酸吡格列酮; U 72107A; AD 4833) 是PPARγ刺激剂。

目录号
EY1405
EY1405
EY1405
纯度
99.26%
99.26%
99.26%
规格
50 mg
100 mg
500 mg
原价
120
200
660
售价
120
200
660
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Pioglitazone HCl is a hydrochloride salt form of pioglitazone, which is an orally active, thiazoledinedione (TZD) and a highly selective PPAR-γ agonist. Pioglitazone is a selective hPPARgamma1 activator and a weak hPPARalpha activator. Binding assay indicated that the transactivation of hPPARgamma1 or hPPARalpha by pioglitazone is due to direct binding of pioglitazone to each subtype.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Xing B, et al. J Neuroinflammation,?008, 5, 4.
    [2] Naito, Y., et al. 2001. Aliment. Pharmacol. Ther. 15: 865-873.
    [3] Ishibashi, M., et al. 2002. Hypertension. 40: 687-693.
    [4] Naito, Y. and Yoshikawa, T. 2004. Drugs Today. 40: 423-430.

    分子式
    C19H21ClN2O3S
    分子量
    392.9
    CAS号
    112529-15-4
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    80 mg/mL
    Water
    <1 mg/mL
    Ethanol
    5 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01873001 Healthy Volunteers Drug: Pioglitazone HCl|Drug: Abiraterone acetate Janssen Research & Development, LLC Phase 1 2013-05-01 2014-04-16
    NCT00649012 Healthy Drug: Pioglitazone HCl Tablets 45 mg|Drug: Actos庐 Tablets 45 mg Mylan Pharmaceuticals Phase 1 2003-03-01 2008-03-31
    NCT00649558 Healthy Drug: Pioglitazone HCl Tablets 45 mg|Drug: Actos庐 Tablets 45 mg Mylan Pharmaceuticals Phase 1 2003-02-01 2008-03-31
    NCT00494559 Diabetes Mellitus|Coronary Artery Stenosis Drug: Pioglitazone|Drug: Placebo Korea University Anam Hospital Phase 4 2007-07-01 2016-02-24
    NCT01090752 Diabetes|Hypertension Drug: Pioglitazone|Drug: Metformin University Hospital, Geneva|University of Lausanne Hospitals Phase 4 2005-10-01 2010-03-24
    NCT03080480 Chronic Granulomatous Disease Drug: Pioglitazone Children's Hospital of Fudan University Phase 1|Phase 2 2017-04-01 2017-03-14
    NCT00671515 Depressive Disorder, Major|Metabolic Syndrome X Drug: Pioglitazone Joseph Calabrese, MD|Takeda Pharmaceuticals North America, Inc.|University Hospitals Cleveland Medical Center Phase 2 2008-04-01 2016-11-30
    NCT02697617 Polycystic Kidney Disease Drug: Pioglitazone|Drug: Placebo Indiana University Phase 2 2015-10-01 2016-10-13
    NCT01151670 Brain Neoplasms, Malignant|Brain Neoplasms, Benign|Malignant Meningioma|Glioblastoma Multiforme|Anaplastic Astrocytoma Drug: pioglitazone|Drug: Pioglitazone Wake Forest University Health Sciences Phase 1 2010-08-01 2017-01-17
    NCT02687425 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Drug: Pioglitazone|Drug: imatinib mesylate Meng Li|Tongji Hospital Phase 2 2016-02-01 2016-02-16
    NCT00719381 Cystic Fibrosis Drug: Pioglitazone Paul Beringer|University of Southern California Phase 1 2008-01-01 2012-06-13
    NCT01637935 Diabetes|Bladder Cancer Drug: Pioglitazone Takeda|Kaiser Permanente|Department of Epidemiology at University of Pennsylvania 2004-07-01 2015-12-09
    NCT01352182 Severe Sepsis|Septic Shock Drug: Pioglitazone hydrochloride Children's Hospital Medical Center, Cincinnati Phase 1|Phase 2 2011-10-01 2017-01-05
    NCT00672919 Diabetes Mellitus Drug: Pioglitazone Takeda Phase 4 2003-11-01 2012-02-27
    NCT01931566 Mild Cognitive Impairment Due to Alzheimer's Disease Drug: Pioglitazone|Drug: Pioglitazone placebo Takeda|Zinfandel Pharmaceuticals Inc. Phase 3 2013-08-01 2017-01-31
    NCT00835120 Metabolic Syndrome|Bipolar Depression|Insulin Resistance Drug: Pioglitazone University Hospitals Cleveland Medical Center|National Alliance for Research on Schizophrenia and Depression|Takeda Pharmaceuticals North America, Inc. Phase 4 2009-03-01 2016-11-30
    NCT00845182 Type 2 Diabetes|Healthy|Impaired Glucose Tolerance Drug: Pioglitazone|Drug: Exenatide|Drug: Pioglitazone and Exenatide The University of Texas Health Science Center at San Antonio Phase 4 2007-06-01 2015-08-08
    NCT00220961 Impaired Glucose Tolerance|Type 2 Diabetes Drug: Pioglitazone|Drug: Placebo The University of Texas Health Science Center at San Antonio|University of Texas|Takeda Pharmaceuticals North America, Inc. Phase 3 2004-01-01 2016-06-29
    NCT02958956 Diabetes Mellitus, Type 2, Cancer Drug: Pioglitazone Takeda 1997-01-01 2016-11-12

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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