Minocycline HCl是一种脂溶性的活性最强的四环素类抗生素,结合到30S核糖体亚基,抑制tRNA与核糖体mRNA复合物结合,干扰蛋白质合成。
Minocycline hydrochloride is the most lipid soluble and most active tetracycline antibiotic, binds to the 30S ribosomal subunit, preventing the binding of tRNA to the mRNA-ribosome complex and interfering with protein synthesis.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
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[4] Giuliani, F., et al. 2005. J. Leukoc. Biol. 78: 135-143.
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分子式 C23H27N3O7.HCl |
分子量 493.94 |
CAS号 13614-98-7 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 100 mM |
Water 25 mM |
Ethanol |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02201563 | Irradiation; Adverse Effect | Drug: Minocycline | University of Pittsburgh | Phase 1 | 2015-11-01 | 2015-12-23 |
NCT01514422 | Bipolar Depression | Drug: Minocycline | Icahn School of Medicine at Mount Sinai | Phase 4 | 2011-05-01 | 2016-12-06 |
NCT01493622 | Schizophrenia | Drug: minocycline|Drug: placebo | Central South University | Phase 4 | 2010-06-01 | 2011-12-14 |
NCT01429272 | Bipolar Disorder Depression | Drug: Minocycline|Drug: Aspirin|Drug: placebo | Laureate Institute for Brain Research, Inc.|Stanley Medical Research Institute|University of Oklahoma | Phase 3 | 2011-09-01 | 2015-10-28 |
NCT00666887 | Clinically Isolated Syndromes|Early Single Relapse of Multiple Sclerosis | Drug: Minocycline|Drug: Placebo | Dr. Luanne Metz|Multiple Sclerosis Society of Canada|University of Calgary | Phase 3 | 2009-01-01 | 2017-02-23 |
NCT01805895 | Intracerebral Hemorrhage | Drug: Minocycline | Augusta University|American Heart Association | Phase 1|Phase 2 | 2013-02-01 | 2016-02-09 |
NCT02312609 | Healthy | Drug: Minocycline hydrochloride | Ranbaxy Laboratories Limited|Ranbaxy Inc. | 2008-09-01 | 2014-12-08 | |
NCT02312297 | Healthy | Drug: Minocycline hydrochloride | Ranbaxy Laboratories Limited|Ranbaxy Inc. | 2008-09-01 | 2014-12-08 | |
NCT02178813 | Stroke | Drug: Administration of minocycline | University of Pittsburgh | Phase 1 | 2014-07-01 | 2016-07-27 |
NCT01561742 | Schizophrenia | Drug: Minocycline|Drug: Placebo | The University of Texas Health Science Center, Houston|Stanley Medical Research Institute | 2012-02-01 | 2012-03-22 | |
NCT00418392 | Pneumothorax | Procedure: Simple aspiration with minocycline pleurodesis|Procedure: simple aspiration | National Taiwan University Hospital | Phase 3 | 2006-11-01 | 2012-12-13 |
NCT00668746 | Periodontitis | Drug: Minocycline HCl microspheres | OraPharma | Phase 4 | 2007-12-01 | 2011-12-06 |
NCT01403662 | Bipolar Disorder|Bipolar Depression|Bipolar I Depression|Bipolar II Depression | Drug: Minocycline | University Health Network, Toronto | Phase 3 | 2011-07-01 | 2016-12-15 |
NCT01779089 | Diabetic Nephropathy | Drug: Minocycline 100 mg po bid for 6 months|Drug: placebo | Los Angeles Biomedical Research Institute | 2009-02-01 | 2015-05-20 | |
NCT00240513 | Acne Vulgaris | Drug: Minocycline|Drug: Minocycline plus tretinoin | Derm Research @ 888 Inc.|Stiefel, a GSK Company | Phase 4 | 2004-08-01 | 2012-02-22 |
NCT02140164 | Retinitis Pigmentosa | Drug: Minocycline | National Eye Institute (NEI)|The EMMES Corporation|National Institutes of Health Clinical Center (CC) | Phase 1|Phase 2 | 2014-05-01 | 2016-11-18 |
NCT03050086 | Moderate to Severe Papulopustular Rosacea | Drug: 1% minocycline topical gel | BioPharmX, Inc. | Phase 1|Phase 2 | 2017-03-01 | 2017-02-08 |
NCT01422148 | Atrial Fibrillation | Drug: Amiodarone|Drug: Minocycline | Baystate Medical Center | 2011-10-01 | 2017-01-30 | |
NCT02541500 | Heroin Dependence|Amphetamine Dependence | Drug: Minocycline | University of Science Malaysia|Yale University | Phase 3 | 2013-04-01 | 2015-09-01 |
NCT02695446 | Acne | Drug: Minocycline | BioPharmX, Inc. | Phase 4 | 2016-03-01 | 2016-05-14 |
NCT01053156 | Fragile X Syndrome | Drug: minocycline hydrochloride|Drug: Placebo | University of California, Davis|The National Fragile X Foundation | 2010-01-01 | 2014-06-30 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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