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Minocycline hydrochloride

盐酸米诺环素

Minocycline HCl是一种脂溶性的活性最强的四环素类抗生素,结合到30S核糖体亚基,抑制tRNA与核糖体mRNA复合物结合,干扰蛋白质合成。

目录号
EY1402
EY1402
纯度
99.32%
99.32%
规格
50 mg
100 mg
原价
400
600
售价
400
600
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Minocycline hydrochloride is the most lipid soluble and most active tetracycline antibiotic, binds to the 30S ribosomal subunit, preventing the binding of tRNA to the mRNA-ribosome complex and interfering with protein synthesis.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Brogden RN, et al. Drugs, 1975, 9(4), 251-291.
    [2] Gilbertson-Beadling, S., et al. 1995. Cancer Chemother. Pharmacol. 36: 418-424.
    [3] Parangi, S., et al. 1996. Proc. Natl. Acad. Sci. U.S.A. 93: 2002-2007.
    [4] Giuliani, F., et al. 2005. J. Leukoc. Biol. 78: 135-143.
    [5] Tao, R., et al. 2010. J. Cardiovasc. Pharmacol. [Epub ahead of print].

    分子式
    C23H27N3O7.HCl
    分子量
    493.94
    CAS号
    13614-98-7
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    100 mM
    Water
    25 mM
    Ethanol

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02201563 Irradiation; Adverse Effect Drug: Minocycline University of Pittsburgh Phase 1 2015-11-01 2015-12-23
    NCT01514422 Bipolar Depression Drug: Minocycline Icahn School of Medicine at Mount Sinai Phase 4 2011-05-01 2016-12-06
    NCT01493622 Schizophrenia Drug: minocycline|Drug: placebo Central South University Phase 4 2010-06-01 2011-12-14
    NCT01429272 Bipolar Disorder Depression Drug: Minocycline|Drug: Aspirin|Drug: placebo Laureate Institute for Brain Research, Inc.|Stanley Medical Research Institute|University of Oklahoma Phase 3 2011-09-01 2015-10-28
    NCT00666887 Clinically Isolated Syndromes|Early Single Relapse of Multiple Sclerosis Drug: Minocycline|Drug: Placebo Dr. Luanne Metz|Multiple Sclerosis Society of Canada|University of Calgary Phase 3 2009-01-01 2017-02-23
    NCT01805895 Intracerebral Hemorrhage Drug: Minocycline Augusta University|American Heart Association Phase 1|Phase 2 2013-02-01 2016-02-09
    NCT02312609 Healthy Drug: Minocycline hydrochloride Ranbaxy Laboratories Limited|Ranbaxy Inc. 2008-09-01 2014-12-08
    NCT02312297 Healthy Drug: Minocycline hydrochloride Ranbaxy Laboratories Limited|Ranbaxy Inc. 2008-09-01 2014-12-08
    NCT02178813 Stroke Drug: Administration of minocycline University of Pittsburgh Phase 1 2014-07-01 2016-07-27
    NCT01561742 Schizophrenia Drug: Minocycline|Drug: Placebo The University of Texas Health Science Center, Houston|Stanley Medical Research Institute 2012-02-01 2012-03-22
    NCT00418392 Pneumothorax Procedure: Simple aspiration with minocycline pleurodesis|Procedure: simple aspiration National Taiwan University Hospital Phase 3 2006-11-01 2012-12-13
    NCT00668746 Periodontitis Drug: Minocycline HCl microspheres OraPharma Phase 4 2007-12-01 2011-12-06
    NCT01403662 Bipolar Disorder|Bipolar Depression|Bipolar I Depression|Bipolar II Depression Drug: Minocycline University Health Network, Toronto Phase 3 2011-07-01 2016-12-15
    NCT01779089 Diabetic Nephropathy Drug: Minocycline 100 mg po bid for 6 months|Drug: placebo Los Angeles Biomedical Research Institute 2009-02-01 2015-05-20
    NCT00240513 Acne Vulgaris Drug: Minocycline|Drug: Minocycline plus tretinoin Derm Research @ 888 Inc.|Stiefel, a GSK Company Phase 4 2004-08-01 2012-02-22
    NCT02140164 Retinitis Pigmentosa Drug: Minocycline National Eye Institute (NEI)|The EMMES Corporation|National Institutes of Health Clinical Center (CC) Phase 1|Phase 2 2014-05-01 2016-11-18
    NCT03050086 Moderate to Severe Papulopustular Rosacea Drug: 1% minocycline topical gel BioPharmX, Inc. Phase 1|Phase 2 2017-03-01 2017-02-08
    NCT01422148 Atrial Fibrillation Drug: Amiodarone|Drug: Minocycline Baystate Medical Center 2011-10-01 2017-01-30
    NCT02541500 Heroin Dependence|Amphetamine Dependence Drug: Minocycline University of Science Malaysia|Yale University Phase 3 2013-04-01 2015-09-01
    NCT02695446 Acne Drug: Minocycline BioPharmX, Inc. Phase 4 2016-03-01 2016-05-14
    NCT01053156 Fragile X Syndrome Drug: minocycline hydrochloride|Drug: Placebo University of California, Davis|The National Fragile X Foundation 2010-01-01 2014-06-30

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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