生物活性

AICAR is a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle.

体外研究

体内研究

0.9% NaCl

激酶实验

细胞实验

2.5 mM

动物实验

50 mg/kg 腹腔内注射

不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

参考文献

[1] Corton JM, et al. Eur J Biochem, 1995, 229(2), 558-565.
[2] Robert G, et al. PLoS One, 2009, 4(11), e7889.
[3] Fabian TC, et al. Surgery, 1996, 119(3), 302-315.
[4] Giri et al (2008) The role of AMPK in psychosine mediated effects on oligodendrocytes and astrocytes: Implication for Krabbe disease. J.Neurochem. 105 1820.
[5] Wu et al (2011) AICAR, a small chemical molecule, primes osteogenic differentiation of adult mesenchymal stem cells. Int.J.Artif.Organs. 34 1128.
[6] Kanazawa et al (2007) Adiponectin and AMP kinase activator stimulate proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells. BMC Cell Biol. 8 51.

体内溶解度

Clinical Trial Information ( data from http://clinicaltrials.gov )

注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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