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Valproic acid sodium salt

Sodium valproate

Valproic acid sodium salt (Sodium valproate)是一种HDAC抑制剂，IC50为0.4 mM，也抑制GABA-转氨酶或琥珀酸半醛脱氢酶。

目录号
EY1327
EY1327
EY1327
纯度
99.52%
99.52%
99.52%
规格
100 mg
200 mg
500 mg
原价
120
220
320
售价
120
220
320
库存
现货
现货
现货
订购
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  • 生物活性

    Valproic Acid Sodium Salt is a branched chain fatty acid which is reported to inhance central GABAergic neurotransmission and inhibit Sodium Channel Protein (Na+ channels). This compound is also reported to cause inositol depletion, activate the ERK pathway, inhibit GSK-3α and GSK-3β. This compound is also an inhibitor of the CYP2C9 enzyme. Valproic Acid Sodium Salt has been reported to be a potent inhibitor of HDAC (histone deacetylase) in vitro (IC50 = 400 μM for HDAC1), thereby relieving HDAC-dependent transcriptional repression and causes the hyperacetylation of histones in cultured cells. In animal studies, Valproic Acid has been observed to reduce tumor growth and metastasis formation. 

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Phiel CJ, et al. J Biol Chem, 2001, 276(39), 36734-36741.
    [2] Tunnicliff, G., et al., 1999. Actions of sodium valproate on the central nervous system. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 50(3): 347-65.
    [3] Göttlicher, M., et al., 2001. Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. The EMBO journal. 20(24): 6969-78.
    [4] Gökçe, Selim., et al., 2010. Valproic acid-associated vanishing bile duct syndrome. Journal of child neurology. 25(7): 909-11.

    分子式
    C8H15NaO2    		 分子量
    166.19    		 CAS号
    1069-66-5    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    50 mM    		 Water
    50 mg/mL    		 Ethanol
    30 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00431522 Bipolar Disorder Drug: Valproic acid, sodium salt Sanofi Phase 4 2004-12-01 2009-05-28
    NCT00228046 Attention Deficit Disorder With Hyperactivity|Conduct Disorder|Oppositional Defiant Disorder Drug: Divalproex Sodium|Drug: Methylphenidate|Drug: Dextroamphetamine|Drug: Mixed Amphetamine Salts|Behavioral: Family Counseling|Behavioral: Behavior Management Training with Parents Stony Brook University|National Institute of Mental Health (NIMH) Phase 4 2004-01-01 2013-10-29
    NCT01960075 Benzodiazepine Refractory Status Epilepticus Drug: Fosphenytoin|Drug: Levetiracetam|Drug: Valproic acid University of Virginia|University of Michigan|Medical University of South Carolina|Children's Research Institute|University of Minnesota - Clinical and Translational Science Institute|National Institute of Neurological Disorders and Stroke (NINDS) Phase 3 2015-10-01 2016-11-03
    NCT01674010 Bipolar 1 Disorder Drug: ELND005|Drug: Lamotrigine|Drug: Valproic acid|Drug: Placebo Transition Therapeutics Ireland Limited|Elan Pharmaceuticals Phase 2 2012-08-01 2016-05-17
    NCT00088452 Childhood Absence Epilepsy|Petit Mal Epilepsy|Epilepsy|Seizures Drug: ethosuximide|Drug: lamotrigine|Drug: valproic acid Children's Hospital Medical Center, Cincinnati|National Institute of Neurological Disorders and Stroke (NINDS) Phase 3 2004-07-01 2017-02-03
    NCT00021866 Epilepsy|Seizure|Cognition Disorders Behavioral: Differential Abilities Scale|Behavioral: Neuropsychological Testing Emory University|National Institute of Neurological Disorders and Stroke (NINDS) 2000-09-01 2013-11-08

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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