Puromycin 2HCl 是一种氨基核苷抗菌素,其可作为蛋白质合成的抑制剂。
Puromycin is toxic to the growth of various eukaryote cells including mammalian cells. Concentrations of puromycin sufficient to inhibit the cell growth of mammalian cells range from 0.5-10 μg/ml. IC90s for puromycin to inhibit the growth of Plasmodium falciparum and Giardia lamblia are 60 ng/ml and 54 μg/ml, respectively. Aminoacyl-tRNA is used as the material for elongation of a synthesizing polypeptide on a ribosome.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Darken MA. Pharmacol Rev. 1964, 16, 223-243.
[2] Brunetti, M., et al. 1995. Blood. 86: 4199-4205.
[3] Constam, D.B., et al. 1995. J. Biol. Chem. 270: 26931-26939.
[4] Sugita, M., et al. 1995. Zool. Sci. 12: 419-425.
[5] Tabuchi, I. 2003. Biochem. Biophys. Res. Commun. 305: 1-5.
分子式 C22H29N7O5.2HCl |
分子量 544.43 |
CAS号 58-58-2 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 100 mM |
Water 100 mM |
Ethanol <1 mg/mL |
体内溶解度
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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