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Amiloride hydrochloride

盐酸阿米洛利,Midamor hydrochloride,Guanamprazine hydrochloride,Amipramidin hydrochloride

Amiloride hydrochloride (盐酸阿米洛利) 是表皮钠离子通道阻断剂。

目录号
EY1233
EY1233
EY1233
纯度
99.27%
99.27%
99.27%
规格
5 mg
10 mg
25 mg
原价
260
390
780
售价
260
390
780
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Amiloride • HCl is an inhibitor of Sodium/Potassium-ATPase Protein. It is a selective T-type calcium channel protein inhibitor that has been shown to inhibit the Polycystin-L channel, a member of the transient receptor potential (TRP) superfamily of cation channels, including the NHE. Research shows that amiloride reduces electrical potential across tubular epithelium, inhibits angiogenesis and inhibits capillary morphogenesis completely and reversibly at approximately 130 μM.

  • 体外研究

  • 体内研究

    2% DMSO+caster oil

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Teiwes J, et al. Am J Hypertens, 2007, 20(1), 109-117.
    [2] Jankun, J., et al. 1999. Cancer Biochem. Biophys. 17: 109-123.
    [3] Loffing, J., et al. 2003. Am. J. Physiol. Renal Physiol. 284 F628-F643.
    [4] Dai, X.Q., et al. 2007. Mol. Pharmacol. 72: 1576-1585.
    [5] Sato, Y., et al. 2010. Anal Chim Acta. 675: 49-52.
    [6] Cao, B.Y., et al. 2010. J Ethnopharmacol. 13: 122-129.

    分子式
    C6H9Cl2N7O
    分子量
    266.09
    CAS号
    2016-88-8
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    25 mg/mL
    Water
    10 mM with gentle warming
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01802489 Optic Neuritis|Multiple Sclerosis Drug: Amiloride|Drug: Placebo University of Oxford|Multiple Sclerosis Society of Great Britain and Northern Ireland Phase 2 2013-02-01 2015-02-03
    NCT02122731 Hypertension|Type 2 Diabetes Mellitus|Microalbuminuria Drug: Amiloride Ib Abildgaard Jacobsen|Odense University Hospital Phase 4 2010-11-01 2014-04-23
    NCT00709137 Hypertension Drug: spironolactone|Drug: amiloride VA Salt Lake City Health Care System 2008-10-01 2014-05-27
    NCT03031496 Hypertension Drug: GSK3542503 (HCTZ 50mg/Amiloride HCl 5mg tablets)|Drug: Moduretic (HCTZ 50mg/Amiloride HCl 5mg tablets) GlaxoSmithKline Phase 1 2017-03-01 2017-03-14
    NCT02522650 Proteinuria Drug: Amiloride|Drug: Triamterene Georgetown University Phase 4 2013-07-01 2016-11-18
    NCT01308983 Prehypertension Drug: Amiloride Augusta University Phase 4 2010-09-01 2012-10-22
    NCT01879527 Optic; Neuritis, With Demyelination Drug: Amiloride hydrochlorothiazide|Drug: Sugar pill Medical University of Vienna Phase 2 2014-03-01 2015-05-08
    NCT01733680 ADHD Drug: amiloride|Behavioral: Behavioral State University of New York - Upstate Medical University Early Phase 1 2012-09-01 2014-11-19
    NCT00274391 Cystic Fibrosis Drug: 7% NaCl|Drug: Amiloride HCl University of North Carolina|Cystic Fibrosis Foundation Therapeutics|University of North Carolina, Chapel Hill Phase 2 2001-07-01 2006-01-09
    NCT01231165 Coronary Heart Disease Drug: Amiloride|Drug: Nitrates, clopidogrel, aspirin, statins University of Carabobo|Clinical Research Unit at the Docent Institute of Urology|Northern Metropolitan Hospital|Venezuelan Foundation of Heart Failure Phase 2|Phase 3 2009-02-01 2012-06-08
    NCT00285805 Insulin Resistance Drug: Rosiglitazone versus placebo|Drug: response (sodium excretion) to amiloride infusion|Drug: response (sodium excretion) to furosemide infusion Radboud University 2006-02-01 2010-08-23
    NCT01388088 Hypertension Drug: Spironolactone|Drug: Amiloride|Drug: Placebo Erling Bjerregaard Pedersen|Regional Hospital Holstebro Phase 4 2010-09-01 2012-03-27
    NCT01195805 Essential Hypertension Drug: Spironolactone|Other: Placebo|Drug: Amiloride Regional Hospital Holstebro 2010-08-01 2015-08-19
    NCT00394394 Hypertension Drug: Amiloride 2,5/d or Enalapril/d 10 mg Hospital de Clinicas de Porto Alegre Phase 2 2005-02-01 2006-10-30
    NCT01804777 Proteinuria|Hypertension|Type II Diabetes Drug: Amiloride|Drug: HCTZ University of New Mexico|Dialysis Clinic, Inc.|University of Pittsburgh Early Phase 1 2013-03-01 2014-09-26
    NCT01095133 Gastroesophageal Reflux Disease|Heartburn Drug: Amiloride|Drug: Placebo University of North Carolina, Chapel Hill Phase 1 2010-03-01 2012-09-18
    NCT01918488 Diabetic Nephropathies|Hypertension Dietary Supplement: Standardized salt diet|Drug: Amiloride University of Southern Denmark|Odense University Hospital|Region of Southern Denmark|The Ministry of Science, Technology and Innovation, Denmark|Danish Heart Foundation 2013-10-01 2013-10-14
    NCT00857909 High Blood Pressure Drug: Amiloride|Drug: Spironolactone|Drug: Placebo|Drug: Placebo and spironolactone|Drug: Spironolactone Regional Hospital Holstebro Phase 1 2009-01-01 2011-07-07

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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