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Lamivudine

拉米夫定,GR109714X

Lamivudine (拉米夫定) 为核苷类似物，是逆转录酶抑制剂，IC50为2.7 mM。

目录号
EY1223
EY1223
EY1223
纯度
99.11%
99.11%
99.11%
规格
50 mg
100 mg
500 mg
原价
300
500
1500
售价
300
500
1500
库存
现货
现货
现货
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  • 生物活性

    Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor with an IC50 of 2.7 mM which acts as a potent reverse transcriptase inhibitor (nRTI). It is effective against both HIV reverse transcriptase 1 and 2, as well as hepatitis B reverse transcriptase.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Shaw T, et al. J Viral Hepat, 1999, 6(2), 89-106.
    [2] Butt, Yasmeen M., et al., . Highly active antiretroviral therapy does not affect mitochondrial beta-oxidation of fatty acids: an in vitro study in fibroblasts. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. 11(1): 35-8.
    [3] Kohler, James J., et al., 2009. Murine cardiac mtDNA: effects of transgenic manipulation of nucleoside phosphorylation. Laboratory investigation; a journal of technical methods and pathology. 89(2): 122-30.
    [4] Perez-Olmeda, M., et al., 2009. In vitro analysis of synergism and antagonism of different nucleoside/nucleotide analogue combinations on the inhibition of human immunodeficiency virus type 1 replication. Journal of medical virology. 81(2): 211-6.

    分子式
    C8H11N3O3S    		 分子量
    229.26    		 CAS号
    134678-17-4    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    46 mg/mL    		 Water
    46 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01013272 Hepatitis B, Chronic Drug: Entecavir|Drug: Lamivudine The University of Hong Kong 2007-06-01 2015-11-30
    NCT00985647 HIV Infections Drug: Lamivudine (3TC) Kirby Institute Phase 1|Phase 2 2009-12-01 2011-02-09
    NCT01627223 Chronic Hepatitis B Drug: Lamivudine|Drug: Entecavir Taichung Veterans General Hospital|GlaxoSmithKline Phase 4 2012-07-01 2016-10-16
    NCT01599364 Human Immunodeficiency Virus Drug: Atazanavir, ritonavir, lamivudine Catholic University of the Sacred Heart Phase 4 2014-04-01 2016-08-14
    NCT01546116 Chronic Hepatitis B Drug: ADEFOVIR, LAMIVUDINE Korea University|GlaxoSmithKline Phase 4 2010-02-01 2014-02-14
    NCT01914744 Non-Hodgkin Lymphoma|Hepatitis B Reactivation Drug: Entecavir|Drug: Lamivudine Fudan University Phase 2 2013-02-01 2013-07-31
    NCT01848743 Chronic HBV With Severe Exacerbation Drug: Tenofovir|Drug: lamivudine Kaohsiung Veterans General Hospital. Phase 3 2013-04-01 2014-09-12
    NCT01376154 Hepatitis B, Chronic Drug: Lamivudine GlaxoSmithKline 2006-06-01 2011-06-16
    NCT02604004 HIV INFECTIONS Drug: Epivir 庐 tablet 150-mg single dose (drug reference)|Drug: Lamivudine 150-mg tablet single dose (drug test) Universidade Federal de Pernambuco Phase 1 2013-04-01 2015-11-10
    NCT00625339 Hepatitis B, Chronic Drug: Entecavir|Drug: Lamivudine Yonsei University|Pusan National University Hospital Phase 4 2008-02-01 2012-05-07
    NCT01220232 Healthy Volunteers Drug: Abacavir/Lamivudine|Drug: Abacavir/Lamivudine|Drug: Lersivirine Pfizer|ViiV Healthcare Phase 1 2010-11-01 2011-02-03
    NCT00637663 Hepatitis B, Chronic Drug: Entecavir|Drug: Lamivudine Pusan National University Hospital|Yonsei University Phase 4 2008-02-01 2015-03-04
    NCT02211482 HIV-1 Infection Drug: dolutegravir, lamivudine The Huesped Foundation|ViiV Healthcare Phase 4 2014-10-01 2016-08-21
    NCT00625560 Hepatitis B, Chronic Drug: Entecavir|Drug: Lamivudine Yonsei University|Pusan National University Hospital Phase 4 2008-02-01 2012-05-07
    NCT01491295 Chronic Hepatitis B Drug: Tenofovir disoproxil fumarate|Drug: Lamivudine plus adefovir Taipei Veterans General Hospital, Taiwan|Kaohsiung Medical University Chung-Ho Memorial Hospital|China Medical University Hospital|Chi Mei Medical Hospital|Chiayi Christian Hospital Phase 4 2012-09-01 2016-03-31
    NCT02384395 HIV|Acute HIV Infection Drug: DTG/3TC/ABC FDC Cynthia L Gay, MD|ViiV Healthcare|National Cancer Institute (NCI)|University of North Carolina, Chapel Hill 2015-09-01 2016-05-03

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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