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Embelin

蒽贝素,Embelic Acid,NSC 91874

Embelin,从矮地茶中分离的一种醌类化合物,是一种细胞凋亡的X染色体抑止剂(XIAP)的抑制剂,无细胞试验中IC50为4.1 μM。

目录号
EY1208
EY1208
EY1208
纯度
99.14%
99.14%
99.14%
规格
5 mg
10 mg
50 mg
原价
290
480
1800
售价
290
480
1800
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Embelin is a cell-permeable benzoquinone compound that exhibits antitumor properties. Specifically antagonizes XIAP-mediated inhibition of caspase-9 activation by directly targeting the Smac and caspase-9 binding domain BIR3 (IC50 = 4.1 uM in a competitive.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

    1-64 μM

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Nikolovska-Coleska Z, et al. J Med Chem, 2004, 47(10), 2430-2440.
    [2] Chitra, M., et al. 2003. Fitoterapia. 74: 401-403.
    [3] Joshi, R., et al. 2007. Chem. Biol. Interact. 167: 125-134.

    分子式
    C17H26O4
    分子量
    294.39
    CAS号
    550-24-3
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    >20 mg/mL
    Water
    Insoluble
    Ethanol
    >10 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01703325 Psoriatic Nails Drug: 0.1% triamcinolone , 0.05% clobetasol propionate ointment Mahidol University Phase 4 2010-11-01 2012-10-07
    NCT00988637 Plaque Psoriasis Drug: Vectical鈩?Ointment weekdays and Clobex庐 Spray weekends regimen|Drug: Clobex庐 Spray morning and Vectical鈩?Ointment evening regimen Galderma Laboratories, L.P. Phase 4 2009-10-01 2012-09-21
    NCT00733954 Plaque Psoriasis Drug: clobetasol propionate spray|Drug: clobetasol propionate ointment Galderma Laboratories, L.P. Phase 4 2007-08-01 2014-04-28
    NCT00842153 Psoriasis Drug: Clobetasol propionate foam|Drug: Vehicle foam Stiefel, a GSK Company|GlaxoSmithKline Phase 4 2007-11-01 2011-12-21
    NCT02573883 Vulvar Lichen Sclerosus Device: Radiofrequency Carbon Dioxide Laser|Drug: Clobetasol Propionate 0.05% ointment Medstar Health Research Institute Phase 3 2015-10-01 2016-04-18
    NCT00864240 Healthy Drug: Clobex TM (Clobetasol) 0.05% Lotion, single exposure Actavis Inc. Phase 1 2005-10-01 2010-08-13
    NCT01557517 Oral Chronic Graft vs Host Disease Drug: Clobetasol Oral Rinse|Drug: Placebo oral rinse National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) Phase 2 2012-01-25 2017-03-02
    NCT00864500 Healthy Drug: Clobetasol Propionate 0.05% lotion, single exposure|Drug: Clobex TM 0.05% Lotion, single exposure Actavis Inc. Phase 1 2005-11-01 2010-08-13
    NCT01745133 Psoriasis Drug: vehicle foam|Drug: calcipotriene|Drug: calcipotriene + clobetasol propionate Leon Kircik, M.D.|Stiefel, a GSK Company|Derm Research, PLLC Phase 4 2013-01-01 2016-11-15
    NCT00852761 Plaque-Type Psoriasis Drug: Olux-E Foam|Drug: Clobex lotion Stiefel, a GSK Company|GlaxoSmithKline Phase 4 2009-03-01 2012-04-19
    NCT01893567 Plaque Psoriasis Drug: Clobex Spray Galderma Laboratories, L.P. Phase 4 2013-07-01 2014-09-03
    NCT00828464 Hand Dermatosis Drug: clobetasol propionate Stiefel, a GSK Company|GlaxoSmithKline Phase 4 2008-10-01 2012-09-21
    NCT00436540 Psoriasis Drug: Clobetasol Propionate 0.05% Spray|Drug: Clobetasol Propionate 0.05% Foam Galderma Laboratories, L.P. Phase 4 2006-03-01 2008-03-27
    NCT00658788 Psoriasis Drug: clobetasol propionate spray 0.05%|Drug: calcitriol ointment Galderma Laboratories, L.P. Phase 3 2008-03-01 2014-08-12
    NCT01111981 Alopecia Drug: Clobetasol Propionate 0.05% Emollient Foam Callender Center for Clinical Research Phase 4 2009-10-01 2010-04-27
    NCT00437216 Psoriasis Drug: Clobetasol Propionate, 0.05%|Drug: Clobetasol propionate, 0.05% Spray Galderma Laboratories, L.P. Phase 4 2006-02-01 2008-03-27
    NCT00881868 Scalp Psoriasis Drug: clobetasol propionate spray 0.05%|Drug: Vehicle spray Galderma Laboratories, L.P. Phase 4 2009-04-01 2012-09-21
    NCT00757874 Vulvar Lichen Sclerosus Drug: Tacrolimus cream|Drug: Clobetasol cream Deana Funaro|Astellas Pharma Inc|St. Justine's Hospital Phase 2 2006-04-01 2015-09-05
    NCT02744378 Oral Lichen Planus Drug: Tacrolimus 0.1%|Drug: Clobetasol 0.05% University of Peradeniya Phase 2 2014-06-01 2016-04-19
    NCT02319616 Toxic Epidermal Necrolysis Drug: Clobetasol 0.05% ointment University of California, Davis Phase 1|Phase 2 2015-06-01 2014-12-17
    NCT01699412 Graft vs Host Disease|Oral Manifestations Drug: Clobetasol|Drug: Dexamethasone Grupo de Estudos Multicentricos em Onco-Hematologia Phase 3 2008-08-01 2012-09-30
    NCT01205880 Psoriasis Drug: Calcitriol ointment|Drug: Clobetasol spray Emer, Jason, M.D.|Galderma Laboratories Phase 4 2009-12-01 2010-09-20

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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