Embelin,从矮地茶中分离的一种醌类化合物,是一种细胞凋亡的X染色体抑止剂(XIAP)的抑制剂,无细胞试验中IC50为4.1 μM。
Embelin is a cell-permeable benzoquinone compound that exhibits antitumor properties. Specifically antagonizes XIAP-mediated inhibition of caspase-9 activation by directly targeting the Smac and caspase-9 binding domain BIR3 (IC50 = 4.1 uM in a competitive.
1-64 μM
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Nikolovska-Coleska Z, et al. J Med Chem, 2004, 47(10), 2430-2440.
[2] Chitra, M., et al. 2003. Fitoterapia. 74: 401-403.
[3] Joshi, R., et al. 2007. Chem. Biol. Interact. 167: 125-134.
分子式 C17H26O4 |
分子量 294.39 |
CAS号 550-24-3 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO >20 mg/mL |
Water Insoluble |
Ethanol >10 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01703325 | Psoriatic Nails | Drug: 0.1% triamcinolone , 0.05% clobetasol propionate ointment | Mahidol University | Phase 4 | 2010-11-01 | 2012-10-07 |
NCT00988637 | Plaque Psoriasis | Drug: Vectical鈩?Ointment weekdays and Clobex庐 Spray weekends regimen|Drug: Clobex庐 Spray morning and Vectical鈩?Ointment evening regimen | Galderma Laboratories, L.P. | Phase 4 | 2009-10-01 | 2012-09-21 |
NCT00733954 | Plaque Psoriasis | Drug: clobetasol propionate spray|Drug: clobetasol propionate ointment | Galderma Laboratories, L.P. | Phase 4 | 2007-08-01 | 2014-04-28 |
NCT00842153 | Psoriasis | Drug: Clobetasol propionate foam|Drug: Vehicle foam | Stiefel, a GSK Company|GlaxoSmithKline | Phase 4 | 2007-11-01 | 2011-12-21 |
NCT02573883 | Vulvar Lichen Sclerosus | Device: Radiofrequency Carbon Dioxide Laser|Drug: Clobetasol Propionate 0.05% ointment | Medstar Health Research Institute | Phase 3 | 2015-10-01 | 2016-04-18 |
NCT00864240 | Healthy | Drug: Clobex TM (Clobetasol) 0.05% Lotion, single exposure | Actavis Inc. | Phase 1 | 2005-10-01 | 2010-08-13 |
NCT01557517 | Oral Chronic Graft vs Host Disease | Drug: Clobetasol Oral Rinse|Drug: Placebo oral rinse | National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) | Phase 2 | 2012-01-25 | 2017-03-02 |
NCT00864500 | Healthy | Drug: Clobetasol Propionate 0.05% lotion, single exposure|Drug: Clobex TM 0.05% Lotion, single exposure | Actavis Inc. | Phase 1 | 2005-11-01 | 2010-08-13 |
NCT01745133 | Psoriasis | Drug: vehicle foam|Drug: calcipotriene|Drug: calcipotriene + clobetasol propionate | Leon Kircik, M.D.|Stiefel, a GSK Company|Derm Research, PLLC | Phase 4 | 2013-01-01 | 2016-11-15 |
NCT00852761 | Plaque-Type Psoriasis | Drug: Olux-E Foam|Drug: Clobex lotion | Stiefel, a GSK Company|GlaxoSmithKline | Phase 4 | 2009-03-01 | 2012-04-19 |
NCT01893567 | Plaque Psoriasis | Drug: Clobex Spray | Galderma Laboratories, L.P. | Phase 4 | 2013-07-01 | 2014-09-03 |
NCT00828464 | Hand Dermatosis | Drug: clobetasol propionate | Stiefel, a GSK Company|GlaxoSmithKline | Phase 4 | 2008-10-01 | 2012-09-21 |
NCT00436540 | Psoriasis | Drug: Clobetasol Propionate 0.05% Spray|Drug: Clobetasol Propionate 0.05% Foam | Galderma Laboratories, L.P. | Phase 4 | 2006-03-01 | 2008-03-27 |
NCT00658788 | Psoriasis | Drug: clobetasol propionate spray 0.05%|Drug: calcitriol ointment | Galderma Laboratories, L.P. | Phase 3 | 2008-03-01 | 2014-08-12 |
NCT01111981 | Alopecia | Drug: Clobetasol Propionate 0.05% Emollient Foam | Callender Center for Clinical Research | Phase 4 | 2009-10-01 | 2010-04-27 |
NCT00437216 | Psoriasis | Drug: Clobetasol Propionate, 0.05%|Drug: Clobetasol propionate, 0.05% Spray | Galderma Laboratories, L.P. | Phase 4 | 2006-02-01 | 2008-03-27 |
NCT00881868 | Scalp Psoriasis | Drug: clobetasol propionate spray 0.05%|Drug: Vehicle spray | Galderma Laboratories, L.P. | Phase 4 | 2009-04-01 | 2012-09-21 |
NCT00757874 | Vulvar Lichen Sclerosus | Drug: Tacrolimus cream|Drug: Clobetasol cream | Deana Funaro|Astellas Pharma Inc|St. Justine's Hospital | Phase 2 | 2006-04-01 | 2015-09-05 |
NCT02744378 | Oral Lichen Planus | Drug: Tacrolimus 0.1%|Drug: Clobetasol 0.05% | University of Peradeniya | Phase 2 | 2014-06-01 | 2016-04-19 |
NCT02319616 | Toxic Epidermal Necrolysis | Drug: Clobetasol 0.05% ointment | University of California, Davis | Phase 1|Phase 2 | 2015-06-01 | 2014-12-17 |
NCT01699412 | Graft vs Host Disease|Oral Manifestations | Drug: Clobetasol|Drug: Dexamethasone | Grupo de Estudos Multicentricos em Onco-Hematologia | Phase 3 | 2008-08-01 | 2012-09-30 |
NCT01205880 | Psoriasis | Drug: Calcitriol ointment|Drug: Clobetasol spray | Emer, Jason, M.D.|Galderma Laboratories | Phase 4 | 2009-12-01 | 2010-09-20 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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