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Naloxone HCl

盐酸纳洛酮

Naloxone盐酸盐是阿片类拮抗剂，对阿片受体的IC50为3 nM。

目录号
EY1177
EY1177
纯度
99.29%
99.29%
规格
100 mg
500 mg
原价
498
1900
售价
498
1900
库存
现货
现货
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  • 生物活性

    Naloxone hydrochloride is an opioid inverse agonist drug used to counter the effects of opiate overdose. Studies have identified this product as a significant immunoadjuvant in cancer immunotherapy.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Liu B, et al. J Pharmacol Exp Ther, 2000, 293(2), 607-617.
    [2] Pinelli and Trivulzio (1997) Quantitative evaluation of opioid withdrawal signs in rats repeatedly treated with morphine and injected with naloxone, in the absence or presence of the antiabstinence agent clonidine. J.Pharmacol.Toxicol.Methods 38 117.
    [3] Spivak et al (1997) Naloxone activation of mu-opioid receptors mutated at a histidine residue lining the opioid cavity. Mol.Pharmacol. 52 983.
    [4] Olson et al (1996) Endogenous opiates: 1995. Peptides 17 1421.

    分子式
    C19H22ClNO4    		 分子量
    363.84    		 CAS号
    357-08-4    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    70 mg/mL    		 Water
    70 mg/mL    		 Ethanol
    4 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01105871 Pain Drug: naloxone|Drug: Placebo University of Washington 2010-08-01 2012-08-17
    NCT01531439 Pain, Postoperative|Postoperative Nausea and Vomiting|Scoliosis Drug: Naloxone|Drug: Naloxone Children's Mercy Hospital Kansas City 2011-06-01 2016-01-26
    NCT02307721 Drug Overdose Drug: Intranasal naloxone|Drug: Intramuscular naloxone|Drug: Remifentanil|Device: Aptar Unidose Norwegian University of Science and Technology|St. Olavs Hospital Phase 1|Phase 2 2014-12-01 2015-10-26
    NCT02405988 Drug Overdose Drug: Intravenous naloxone|Drug: Remifentanil Norwegian University of Science and Technology|St. Olavs Hospital 2015-04-01 2017-02-02
    NCT01935206 Hyperalgesia|Pain|Naloxone|Opioid Antagonist Drug: Naloxone (2 mg/kg)|Drug: Placebo Rigshospitalet, Denmark Phase 1 2013-06-01 2014-02-24
    NCT00890942 Morphine Adverse Reaction Drug: naloxone|Drug: normal saline Mahidol University 2009-05-01 2011-07-22
    NCT02137213 Constipation Drug: Naloxone|Drug: Placebo Centre for Addiction and Mental Health|Academic Health Science Centres Phase 2 2014-08-01 2015-06-23
    NCT02700048 Hypoglycemia Unawareness|Type 1 Diabetes Drug: intra-nasal naloxone|Drug: Intra-nasal saline University of Minnesota - Clinical and Translational Science Institute Phase 1|Phase 2 2016-06-01 2016-08-01
    NCT02733822 Drug Overdose|Opioid-Related Disorders Drug: Naloxone King's College London Phase 1 2016-06-01 2016-05-16
    NCT02581111 Brain Death|Organ Donors|Lung Transplantation Drug: Naloxone|Drug: Normal saline Washington University School of Medicine Phase 2|Phase 3 2015-09-01 2016-05-23
    NCT01939444 Drug Overdose Drug: naloxone intranasal|Drug: naloxone intravenous Norwegian University of Science and Technology|St. Olavs Hospital|University of Iceland Phase 2 2013-08-01 2015-01-02
    NCT02669901 Opiate Antagonist Overdose|Opioid-Related Disorders Behavioral: Naloxone Auto-Injector University of New Mexico|Kaleo Pharmaceuticals 2016-04-01 2016-10-24
    NCT00880841 Healthy Drug: Buprenorphine / Naloxone Nanotherapeutics, Inc. 2009-04-01 2016-04-11
    NCT01912573 Drug Overdose Drug: Intranasal (IN) naloxone|Drug: Intravenous (IV) naloxone|Drug: Intramuscular (IM) naloxone|Drug: Intraosseus (IO) naloxone Judith Feinberg|University of Cincinnati Phase 4 2013-09-01 2013-07-29
    NCT02158117 Drug Overdose Drug: nasal naloxone Norwegian University of Science and Technology|St. Olavs Hospital Phase 1 2014-03-01 2017-02-02
    NCT01160432 Opiate Dependence Drug: Methadone, naloxone Kuopio University Hospital 2013-05-01 2013-07-03
    NCT02294253 Opioid Dependence Drug: Buprenorphine/naloxone New York State Psychiatric Institute|National Institute on Drug Abuse (NIDA) Phase 2|Phase 3 2014-09-01 2014-11-18
    NCT01071057 Pruritus Drug: Naloxone|Drug: Saline/Morphine University of British Columbia Phase 2|Phase 3 2010-12-01 2015-01-16
    NCT02120612 Opioid Dependence|Opioid Use Disorder Other: Naloxone Education Intervention Edward Hospital|Edward-Elmhurst Health System 2014-04-01 2017-02-06
    NCT00799201 Constipation|Analgesia Drug: Naloxone and Docusate CAMC Health System Phase 4 2007-08-01 2015-07-27

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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