-
生物活性
Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM. Specifically inhibits Ras selective lethal compound -induced death, but not cell death induced by other oxidative lethal compounds and apoptosis-inducing agents. Inhibits ferroptosis in cancer cells; also inhibits glutamate-induced cell death in organotypic rat brain slices. It appears that Ferrostatin-1 controls lipid soluble ROS. Prevents erastin induced accumulation of cytosolic and lipid reactive oxygen species.
-
体外研究
-
体内研究
-
激酶实验
-
细胞实验
-
动物实验
-
不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）
|  动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 |
|
例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。
-
参考文献
[1] Dixon SJ, et al. Cell, 2012, 149(5), 1060-1072.
[2] Louandre et al (2013) Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib. Int.J.Cancer 133 1732.
[3] Skouta et al (2014) Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models. J.Am.Chem.Soc. 136 4551.
分子式
C15H22N2O2 |
分子量
262.35 |
CAS号
347174-05-4 |
储存方式
﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂（常温）
|
DMSO
100 mM |
Water
<1 mg/mL |
Ethanol
100 mM |
体内溶解度
-
Clinical Trial Information ( data from http://clinicaltrials.gov )
注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。
-
相关化合物库
-
使用AMQUAR产品发表文献后请联系我们
