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生物活性
CAPE derives from honeybee propolis and has several biological activities. It is found to be an inhibitor of NF-κB activation. In U937 cells, CAPE inhibits the TNF-dependent activation of NF-κB dose-dependently. The maximum effect occurs at dose of 25μg/ml. CAPE also inhibits NF-κB activation induced by phorbol ester, ceramide, okadaic acid and hydrogen peroxide. It is reported that CAPE prevents NF-κB from binding to DNA without affecting other transcription factors. CAPE also has angiogenesis efficacy. It shows inhibition effect on the formation of capillary-like tubes. Besides, it reduces the production of VEGF both in CT26 cell culture and in animal model. In addition, CAPE effectively prevents CT26 cells from secreting MMP-2 and MMP-9.
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体外研究
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体内研究
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激酶实验
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细胞实验
~200 μM
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动物实验
~10mg/kg 腹腔注射
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不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）
|  动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 |
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例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。
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参考文献
[1] Natarajan K, et al. Proc Natl Acad Sci U S A. 1996, 93(17), 9090-9095.
[2] Sud'ina, G.F., et al. 1993. FEBS Lett. 329: 21-24.
[3] Su, Z.Z., et al. 1995. Anticancer Res. 15: 1841-1848.
[4] Chiao, C., et al. 1995. Cancer Res. 55: 3576-3583.
[5] Huang, M.T., et al. 1996. Carcinogenesis. 17: 761-765.
分子式
C17H16O4 |
分子量
284.31 |
CAS号
104594-70-9 |
储存方式
﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂（常温）
|
DMSO
>40 mg/mL |
Water
Insoluble |
Ethanol
>40 mg/mL |
体内溶解度
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Clinical Trial Information ( data from http://clinicaltrials.gov )
| NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
| NCT02744703 | Matrix Metalloproteinase Inhibitors|Composite Resins | Drug: total-etch adhesive|Drug: CAPE-T|Drug: self-etch adhesive|Drug: CAPE-S | Ege University | | 2013-04-01 | 2016-04-15 |
注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。
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