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Voriconazole

伏立康唑,UK-109496

Voriconazole是第二代三唑类抗真菌化合物,可作用于严重的真菌感染。

目录号
EY1126
EY1126
EY1126
EY1126
纯度
99.11%
99.11%
99.11%
99.11%
规格
1 mg
5 mg
10 mg
50 mg
原价
112
232
385
789
售价
112
232
385
789
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Voriconazole(UK-109496) is a second-generation triazole antifungal used to treat serious fungal infections. This compound, like many antifungal agents, is an inhibitor of CYP2C9, an enzyme involved in the oxidative metabolism of many xenobiotics. Voriconazole is an inhibitor of CYP51A1.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Espinel-Ingroff A, et al. J Clin Microbiol, 1998, 36(1), 198-202.
    [2] Sanati, H., et al.: Antimicrob. Ag. Chemother., 41, 2492 (1997)
    [3] Kappe (1999) Antifungal activity of the new azole UK-109,496 (voriconazole). Mycoses 42 82.
    [4] Marco et al (1998) In vitro activities of voriconazole (UK-190-496) and four other antifungal agents against 394 clinical isolates of Candida spp. Antimicrob.Agents Chemother. 42 161.

    分子式
    C16H14F3N5O
    分子量
    349.31
    CAS号
    137234-62-9
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    66 mg/mL
    Water
    <1 mg/mL
    Ethanol
    20 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00855101 Healthy Volunteers Drug: voriconazole Pfizer Phase 1 2009-04-01 2010-06-11
    NCT00300677 Infections, Fungal Drug: voriconazole Pfizer|McLean Hospital. Belmont, MA. Phase 4 2007-03-01 2009-10-05
    NCT01030653 Healthy Drug: Voriconazole low dose|Drug: Voriconazole high dose Manjunath Prakash Pai|TKL Research, Inc.|Pfizer|University of Michigan Phase 4 2009-11-01 2016-12-16
    NCT01151085 Systemic Mycosis Drug: Voriconazole Pfizer 2006-04-01 2013-05-14
    NCT02100761 Invasive Pulmonary Aspergillosis Drug: Voriconazole dingshifang|Shandong Provincial Hospital|Qianfoshan Hospital|Shandong thorax hospital|Jinan Military General Hospital|Jinan Central Hospital|Qilu Hospital 2014-06-01 2014-03-31
    NCT01101386 Fungal Infection Drug: Voriconazole University of Colorado, Denver Phase 4 2010-05-01 2014-05-20
    NCT01887457 Immunocompromised Patient|Aspergillosis|Fusarium Drug: VFEND Brynn Chappell|The Christie NHS Foundation Trust Phase 2 2014-09-01 2015-10-06
    NCT01660334 Scedosporium Infection Drug: Voriconazole Pfizer 2006-07-01 2013-10-30
    NCT01185405 Invasive Fungal Infection Other: Use of different strategy for voriconazole dosage adjustment Asan Medical Center 2010-08-01 2013-09-29
    NCT02110316 Voriconazole|Bioavailability|Critically Ill Other: Dosage form of voriconazole University Medical Center Groningen Phase 4 2015-06-01 2016-09-01
    NCT00893555 Invasive Fungal Infection|Hematological Malignancy Drug: voriconazole|Drug: voriconazole (dosing according to the SPC) Jan-Willem C Alffenaar|University Medical Center Nijmegen|Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)|VU University Medical Center|Leiden University Medical Center|UMC Utrecht|Erasmus Medical Center|St. Antonius Hospital|Meander Medical Center|Haga Hospital, Leyweg|Klinikum Oldenburg gGmbH|University Medical Center Groningen Phase 3 2009-04-01 2017-01-11
    NCT00792246 Graft Versus Host Disease|Stem Cell Transplantation Drug: voriconazole|Drug: voriconazole Phillip Brian Smith|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|Duke University Phase 1 2008-12-01 2012-11-09
    NCT00556998 Pharmacokinetics Drug: Voriconazole Pfizer Phase 2 2008-06-01 2016-03-31
    NCT01188759 Aspergillosis|Invasive Pulmonary Aspergillosis|Neuroaspergillosis Drug: Voriconazole|Drug: Anidulafungin|Drug: Voriconazole Pfizer Phase 3 2012-05-01 2012-05-10
    NCT01092832 Candidiasis Drug: voriconazole Pfizer Phase 3 2010-10-01 2016-05-17
    NCT01480219 Non-Melanoma Skin Carcinoma Drug: voriconazole (Vfend)|Other: no voriconazole (Vfend) Pfizer|University of Southern California 2011-08-01 2013-02-04
    NCT01137292 Invasive Fungal Infections Drug: voriconazole (VFEND庐) Pfizer 2007-04-01 2011-08-31
    NCT02396225 Invasive Aspergillosis Drug: Voriconazole University of Aarhus|Aarhus University Hospital 2015-03-01 2016-12-22
    NCT02904434 Infection Other: Grapefruit Juice Children's Hospital of Philadelphia Phase 1 2016-09-01 2016-09-13
    NCT00531479 Aspergillosis Drug: voriconazole|Drug: anidulafungin|Drug: voriconazole Pfizer Phase 3 2008-07-01 2012-04-03
    NCT01976078 Pharmacokinetics|Voriconazole Drug: Midazolam/Ranitidine/Esomeprazole Children's Hospital Los Angeles|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Phase 1 2012-09-01 2016-08-24
    NCT02283905 Blastomycosis Drug: amphotericin-B|Drug: voriconazole University of Manitoba|Pfizer Phase 4 2015-06-01 2016-08-31

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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