Voriconazole是第二代三唑类抗真菌化合物,可作用于严重的真菌感染。
Voriconazole(UK-109496) is a second-generation triazole antifungal used to treat serious fungal infections. This compound, like many antifungal agents, is an inhibitor of CYP2C9, an enzyme involved in the oxidative metabolism of many xenobiotics. Voriconazole is an inhibitor of CYP51A1.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Espinel-Ingroff A, et al. J Clin Microbiol, 1998, 36(1), 198-202.
[2] Sanati, H., et al.: Antimicrob. Ag. Chemother., 41, 2492 (1997)
[3] Kappe (1999) Antifungal activity of the new azole UK-109,496 (voriconazole). Mycoses 42 82.
[4] Marco et al (1998) In vitro activities of voriconazole (UK-190-496) and four other antifungal agents against 394 clinical isolates of Candida spp. Antimicrob.Agents Chemother. 42 161.
分子式 C16H14F3N5O |
分子量 349.31 |
CAS号 137234-62-9 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 66 mg/mL |
Water <1 mg/mL |
Ethanol 20 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT00855101 | Healthy Volunteers | Drug: voriconazole | Pfizer | Phase 1 | 2009-04-01 | 2010-06-11 |
NCT00300677 | Infections, Fungal | Drug: voriconazole | Pfizer|McLean Hospital. Belmont, MA. | Phase 4 | 2007-03-01 | 2009-10-05 |
NCT01030653 | Healthy | Drug: Voriconazole low dose|Drug: Voriconazole high dose | Manjunath Prakash Pai|TKL Research, Inc.|Pfizer|University of Michigan | Phase 4 | 2009-11-01 | 2016-12-16 |
NCT01151085 | Systemic Mycosis | Drug: Voriconazole | Pfizer | 2006-04-01 | 2013-05-14 | |
NCT02100761 | Invasive Pulmonary Aspergillosis | Drug: Voriconazole | dingshifang|Shandong Provincial Hospital|Qianfoshan Hospital|Shandong thorax hospital|Jinan Military General Hospital|Jinan Central Hospital|Qilu Hospital | 2014-06-01 | 2014-03-31 | |
NCT01101386 | Fungal Infection | Drug: Voriconazole | University of Colorado, Denver | Phase 4 | 2010-05-01 | 2014-05-20 |
NCT01887457 | Immunocompromised Patient|Aspergillosis|Fusarium | Drug: VFEND | Brynn Chappell|The Christie NHS Foundation Trust | Phase 2 | 2014-09-01 | 2015-10-06 |
NCT01660334 | Scedosporium Infection | Drug: Voriconazole | Pfizer | 2006-07-01 | 2013-10-30 | |
NCT01185405 | Invasive Fungal Infection | Other: Use of different strategy for voriconazole dosage adjustment | Asan Medical Center | 2010-08-01 | 2013-09-29 | |
NCT02110316 | Voriconazole|Bioavailability|Critically Ill | Other: Dosage form of voriconazole | University Medical Center Groningen | Phase 4 | 2015-06-01 | 2016-09-01 |
NCT00893555 | Invasive Fungal Infection|Hematological Malignancy | Drug: voriconazole|Drug: voriconazole (dosing according to the SPC) | Jan-Willem C Alffenaar|University Medical Center Nijmegen|Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)|VU University Medical Center|Leiden University Medical Center|UMC Utrecht|Erasmus Medical Center|St. Antonius Hospital|Meander Medical Center|Haga Hospital, Leyweg|Klinikum Oldenburg gGmbH|University Medical Center Groningen | Phase 3 | 2009-04-01 | 2017-01-11 |
NCT00792246 | Graft Versus Host Disease|Stem Cell Transplantation | Drug: voriconazole|Drug: voriconazole | Phillip Brian Smith|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|Duke University | Phase 1 | 2008-12-01 | 2012-11-09 |
NCT00556998 | Pharmacokinetics | Drug: Voriconazole | Pfizer | Phase 2 | 2008-06-01 | 2016-03-31 |
NCT01188759 | Aspergillosis|Invasive Pulmonary Aspergillosis|Neuroaspergillosis | Drug: Voriconazole|Drug: Anidulafungin|Drug: Voriconazole | Pfizer | Phase 3 | 2012-05-01 | 2012-05-10 |
NCT01092832 | Candidiasis | Drug: voriconazole | Pfizer | Phase 3 | 2010-10-01 | 2016-05-17 |
NCT01480219 | Non-Melanoma Skin Carcinoma | Drug: voriconazole (Vfend)|Other: no voriconazole (Vfend) | Pfizer|University of Southern California | 2011-08-01 | 2013-02-04 | |
NCT01137292 | Invasive Fungal Infections | Drug: voriconazole (VFEND庐) | Pfizer | 2007-04-01 | 2011-08-31 | |
NCT02396225 | Invasive Aspergillosis | Drug: Voriconazole | University of Aarhus|Aarhus University Hospital | 2015-03-01 | 2016-12-22 | |
NCT02904434 | Infection | Other: Grapefruit Juice | Children's Hospital of Philadelphia | Phase 1 | 2016-09-01 | 2016-09-13 |
NCT00531479 | Aspergillosis | Drug: voriconazole|Drug: anidulafungin|Drug: voriconazole | Pfizer | Phase 3 | 2008-07-01 | 2012-04-03 |
NCT01976078 | Pharmacokinetics|Voriconazole | Drug: Midazolam/Ranitidine/Esomeprazole | Children's Hospital Los Angeles|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Phase 1 | 2012-09-01 | 2016-08-24 |
NCT02283905 | Blastomycosis | Drug: amphotericin-B|Drug: voriconazole | University of Manitoba|Pfizer | Phase 4 | 2015-06-01 | 2016-08-31 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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