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Bleomycin Sulfate

硫酸博莱霉素,博来霉素,争光霉素,NSC125066,NSC-125066,NSC 125066,Blenoxane

Bleomycin Sulfate是一种糖肽类抗生素，作用于UT-SCC-19A细胞，IC50为4 nM。

目录号
EY0978
EY0978
EY0978
EY0978
纯度
99.17%
99.17%
99.17%
99.17%
规格
1 mg
5 mg
25 mg
50 mg
原价
200
600
2200
3600
售价
200
600
2200
3600
库存
现货
现货
现货
现货
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  • 生物活性

    Bleomycin sulfate (BLENOXANE®) is a mixture of cytotoxic glycopeptide antibiotics produced by a strain of streptomyces verticillus. This component is known to cause single and/ or double-stranded breaks in DNA through approximating metals and coordinate dioxygen to generate the active species.

  • 体外研究

  • 体内研究

    Saline

  • 激酶实验

  • 细胞实验

    2.5 μg/mL

  • 动物实验

    5 mg/kg, 2 ml/kg 鞘内注射给药

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Hüttenhofer, A., et al. 1992. J. Biol. Chem. 267: 24471-24475.
    [2] Holmes, C.E., et al. 1997. Bioorg. Med. Chem. 5: 1235-1248.
    [3] Petering, D.H., et al. 1990. Chem. Biol. Interact. 73: 133-182.

    分子式
    C55H85N17O25S4    		 分子量
    1512.62    		 CAS号
    9041-93-4    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    >20 mg/mL    		 Water
    >20 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00198263 Head and Neck Cancer Device: Medpulser Electroporation with Bleomycin Inovio Pharmaceuticals Phase 4 2004-01-01 2012-11-09
    NCT01872923 Cutaneous or Sub-cutaneous Malignancies Drug: Amphinex|Drug: Bleomycin|Device: Laser PCI Biotech AS Phase 1 2012-01-01 2014-06-13
    NCT00003110 Lymphoma Biological: bleomycin sulfate Case Comprehensive Cancer Center|National Cancer Institute (NCI) Phase 2 1997-07-01 2010-06-10
    NCT00198328 Head and Neck Cancer Device: Medpulser Electroporation with Bleomycin|Procedure: Surgical Excision Inovio Pharmaceuticals Phase 3 2004-11-01 2012-09-27
    NCT00198315 Head and Neck Cancer Device: Medpulser electroporation with Bleomycin|Procedure: Tumor surgical excision Inovio Pharmaceuticals Phase 3 2004-06-01 2013-10-08
    NCT00198276 Cancer Device: MedPulser Electroporation with bleomycin Inovio Pharmaceuticals Phase 4 2004-02-01 2013-04-24
    NCT01042522 Ovarian Granulosa Cell Tumor|Ovarian Gynandroblastoma|Ovarian Sertoli-Leydig Cell Tumor|Ovarian Sex Cord Tumor With Annular Tubules|Ovarian Sex Cord-Stromal Tumor|Ovarian Sex Cord-Stromal Tumor of Mixed or Unclassified Cell Types|Ovarian Steroid Cell Tumor Biological: Bleomycin Sulfate|Drug: Carboplatin|Drug: Cisplatin|Drug: Etoposide Phosphate|Other: Laboratory Biomarker Analysis|Drug: Paclitaxel Gynecologic Oncology Group|National Cancer Institute (NCI) Phase 2 2010-02-01 2016-03-16
    NCT00006916 Brain and Central Nervous System Tumors Biological: bleomycin|Device: Ommaya reservoir|Radiation: radiation therapy Radiation Therapy Oncology Group|National Cancer Institute (NCI) Phase 2 2001-06-01 2015-11-14
    NCT02883023 Capillary Malformations|Vascular Malformations Other: Electrosclerotherapy|Drug: Intralesional bleomycin injection Sophie Horbach|IGEA|Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Phase 2 2016-11-01 2016-08-29
    NCT00027521 Pancreatic Cancer Biological: bleomycin sulfate|Drug: electroporation therapy Ichor Medical Systems Incorporated|National Cancer Institute (NCI) Phase 1 2000-12-01 2012-09-17
    NCT00006035 Melanoma (Skin) Biological: bleomycin sulfate|Drug: electroporation therapy H. Lee Moffitt Cancer Center and Research Institute|National Cancer Institute (NCI) Phase 1 2000-06-01 2013-09-16
    NCT01347294 Venous Malformation Drug: Bleomycin|Drug: Fibrovein|Drug: Bleomycin + Fibrovein Oslo University Hospital Phase 4 2011-08-01 2017-02-17
    NCT01606566 Recurrent Head and Neck Cancer|Carcinoma, Squamous Cell of Head and Neck Drug: Amphinex induced PCI of bleomycin PCI Biotech AS Phase 2 2012-04-01 2016-09-27
    NCT00993512 Head and Neck Neoplasms|Skin Neoplasms Drug: Amphinex (TPCS2a)|Drug: Bleomycin|Other: Illumination with CeramOptec laser PCI Biotech AS Phase 1 2009-08-01 2011-06-17
    NCT01404936 Lymphoma Drug: Interferon-2A|Drug: Adriamycin|Drug: Bleomycin|Drug: Velban|Drug: Dacarbazine M.D. Anderson Cancer Center|Schering-Plough Phase 2 1996-07-01 2013-01-30
    NCT00002872 Metastatic Cancer Biological: bleomycin sulfate|Drug: doxycycline|Other: talc Eastern Cooperative Oncology Group|National Cancer Institute (NCI)|North Central Cancer Treatment Group Phase 3 1996-11-01 2013-08-28
    NCT00002105 Sarcoma, Kaposi|HIV Infections Drug: Doxorubicin hydrochloride (liposomal)|Drug: Bleomycin sulfate|Drug: Vincristine sulfate Sequus Pharmaceuticals|NIH AIDS Clinical Trials Information Service Phase 3 null 2005-06-23
    NCT01873326 Germ Cell Tumors Drug: Paclitaxel|Drug: Ifosfamide|Drug: Cisplatin|Drug: Mesna|Drug: Bleomycin|Drug: Etoposide Memorial Sloan Kettering Cancer Center|University of Southern California|Mayo Clinic|University of Pittsburgh|University of North Carolina|University of Chicago|Stanford University|University of Texas Southwestern Medical Center Phase 2 2013-06-01 2017-01-24
    NCT02341989 Testicular Neoplasms|Seminoma Drug: Bleomycin Etoposide and Cisplatin|Drug: Carboplatin St. Olavs Hospital|Sk氓ne University Hospital|Haukeland University Hospital|University Hospital of North Norway|Sahlgrenska University Hospital, Sweden|Karolinska Institutet|Oslo University Hospital|Uppsala University Hospital|University Hospital, Linkoeping|Skane University Hospital|Norrlands University Hospital Phase 3 2015-04-01 2016-10-13
    NCT00001059 Sarcoma, Kaposi|HIV Infections Drug: Doxorubicin hydrochloride (liposomal)|Drug: Filgrastim|Drug: Bleomycin sulfate|Drug: Vincristine sulfate National Institute of Allergy and Infectious Diseases (NIAID)|Sequus Pharmaceuticals|Amgen Phase 2 null 2012-04-13
    NCT00324298 Drug/Agent Toxicity by Tissue/Organ|Testicular Germ Cell Tumor Biological: bleomycin sulfate|Drug: cisplatin|Drug: etoposide|Procedure: management of therapy complications Queen Mary University of London|National Cancer Institute (NCI) Phase 3 2003-07-01 2013-08-09
    NCT00002318 Sarcoma, Kaposi|HIV Infections Drug: Doxorubicin hydrochloride (liposomal)|Drug: Bleomycin sulfate|Drug: Vincristine sulfate|Drug: Doxorubicin hydrochloride Sequus Pharmaceuticals|NIH AIDS Clinical Trials Information Service Phase 3 null 2005-06-23
    NCT00165438 Hodgkin's Disease Procedure: Pulmonary Function Tests|Procedure: CAT Scan Dana-Farber Cancer Institute|Brigham and Women's Hospital 2001-10-01 2012-12-19
    NCT00002093 Sarcoma, Kaposi|HIV Infections Drug: Daunorubicin (liposomal)|Drug: Bleomycin sulfate|Drug: Vincristine sulfate|Drug: Doxorubicin hydrochloride Nexstar Pharmaceuticals|NIH AIDS Clinical Trials Information Service Phase 3 null 2005-06-23
    NCT00132613 Malignant Pericardial Effusion Procedure: Observation alone after pericardial drainage|Drug: Pericardial instillation of bleomycin after drainage Japan Clinical Oncology Group|Ministry of Health, Labour and Welfare, Japan Phase 3 1999-08-01 2016-09-20
    NCT00000681 Sarcoma, Kaposi|HIV Infections Drug: Bleomycin sulfate|Drug: Vincristine sulfate|Drug: Doxorubicin hydrochloride|Drug: Zidovudine|Drug: Sargramostim National Institute of Allergy and Infectious Diseases (NIAID) Phase 1 null 2012-04-26

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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