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Indomethacin

吲哚美辛,Indocin,Indometacin

Indomethacin是非甾体抗炎化合物，可作用于发烧，肿胀和疼痛等。

目录号
EY0951
EY0951
EY0951
纯度
99.38%
99.38%
99.38%
规格
50 mg
100 mg
500 mg
原价
80
120
300
售价
80
120
300
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
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  • 生物活性

    Indomethacin is a nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL. Inhibits Cox-1 and Cox-2 (cyclooxygenases) with selectivity for Cox-1 (IC50 of 230 nM) over Cox-2 (IC50 of 630 nM). Additionally, indomethacin displays adipogenic actions via binding and activation of PPARγ (peroxisome proliferator-activated receptor γ), a ligand-activated transcription factor known to play an important role in adipogenesis.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Dihlmann S, et al. Oncogene, 2001, 20(5), 645-653.
    [2] Salari, H., et al. 1984. Prostaglandins Leukot. Med. 13: 53-60.
    [3] Meade, E.A., et al. 1993. J. Biol. Chem. 268: 6610-6614.
    [4] Lehmann, J.M., et al. 1997. J. Biol. Chem. 272: 3406-3410.
    [5] Zhou, Y., et al. 2010. J. Biol. Chem. [Epub ahead of print].

    分子式
    C19H16ClNO4    		 分子量
    357.79    		 CAS号
    53-86-1    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    25 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    25 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02002650 Post-ERCP Acute Pancreatitis Drug: Pre-ERCP rectal Indomethacin|Drug: Post-operational Rectal Indomethacin Fourth Military Medical University 2013-12-01 2016-05-27
    NCT02110810 Post ERCP Acute Pancreatitis Drug: Indomethacin|Drug: 2.6-g suppository of glycerin Instituto Mexicano del Seguro Social Phase 3 2014-01-01 2015-03-23
    NCT02642601 Difficult Embryo Transfer Drug: Indomethacin(KAHIRA PHARMA&CHEM,IND,CO.CAIRO-EGYPT) Cairo University Phase 2|Phase 3 2014-03-01 2015-12-24
    NCT02111707 Acute Pancreatitis Drug: Rectal indomethacin 100mg one time before or after ERCP University of Alberta Phase 4 2014-04-01 2016-09-14
    NCT02633969 Pain, Postoperative Drug: Indomethacin Capsules low dose|Drug: Indomethacin Capsules high dose Iroko Pharmaceuticals, LLC Phase 2 2015-12-01 2017-01-27
    NCT01869361 Preterm Labor Drug: Indomethacin|Drug: Placebo MetroHealth Medical Center 2016-11-01 2016-09-13
    NCT02692391 Acute Pancreatitis Drug: Indomethacin|Drug: Placebo University of Pittsburgh Phase 3 2014-07-01 2017-02-02
    NCT02221219 Intraventricular Hemorrhage|Periventricular Leukomalacia|Brain Injury|Renal Injury Drug: Indomethacin|Procedure: delay in umbilical cord clamp at birth John Bauer|University of Kentucky Phase 1|Phase 2 2014-08-01 2014-08-19
    NCT00750581 Patent Ductus Arteriosus Drug: Indomethacin University of Calgary Phase 2|Phase 3 2008-08-01 2016-08-17
    NCT01774604 Post-ERCP Acute Pancreatitis Drug: Indomethacin|Drug: Placebo Dartmouth-Hitchcock Medical Center Phase 3 2013-01-01 2016-09-28
    NCT02935205 Metastatic Prostate Carcinoma|Recurrent Prostate Carcinoma|Stage IV Prostate Cancer Drug: Enzalutamide|Drug: Indomethacin University of California, Davis|National Cancer Institute (NCI) Phase 1|Phase 2 2017-01-01 2016-10-13
    NCT01073670 Hemorrhage Drug: Indomethacin|Drug: Acetaminophen & Indomethacin|Drug: Acetaminophen Queen's University Phase 4 2000-08-01 2010-02-22
    NCT01360034 Obstetric Labor, Premature Drug: Nifedipine|Drug: Indomethacin Saint Thomas Hospital, Panama Phase 3 2015-12-01 2015-01-01
    NCT02711358 Family Planning Drug: indomethacin suppositories|Drug: placebo Assiut University Phase 4 2016-03-01 2016-11-28
    NCT00728117 Patent Ductus Arteriosus Other: feeding|Other: fasting University of California, San Francisco 2008-07-01 2012-11-08
    NCT01957215 Ankle Sprain Drug: Indomethacin|Drug: Placebo GlaxoSmithKline|Rundo International Pharmaceutical Research & Development Co.,Ltd. Phase 4 2013-10-01 2015-05-21
    NCT02438371 Preterm Labor Drug: Nifedipine|Drug: Indomethacin The University of Texas Health Science Center, Houston Phase 4 2015-05-01 2015-12-03
    NCT02476279 Post-ERCP Pancreatitis Other: Indomethacin 100 mg rectally immediately after ERCP, NO prophylactic pancreatic stent placement|Other: Indomethacin 100 mg rectally immediately after ERCP AND prophylactic pancreatic stent placement Medical University of South Carolina|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Phase 3 2015-09-01 2016-09-12
    NCT00009646 Infant, Very Low Birth Weight|Infant, Premature|Ductus Arteriosus, Patent Drug: indomethacin|Drug: Indomethacin|Drug: Placebo NICHD Neonatal Research Network|Medical Research Council of Canada|National Center for Research Resources (NCRR) Phase 3 1993-11-01 2015-06-03
    NCT02116309 Post-ERCP Acute Pancreatitis Drug: Rectal Indomethacin|Drug: Epinephrine Johns Hopkins University|American Society for Gastrointestinal Endoscopy|Asian Institute of Gastroenterology, India|Postgraduate Institute of Medical Education and Research|Apollo Gleneagles Hospitals, Kolkata 2014-08-01 2017-03-01
    NCT00727740 Pancreatitis Drug: Indomethacin|Drug: Placebo suspension Yale University 2005-08-01 2016-11-23
    NCT00226122 Enuresis Drug: Indomethacin University of Aarhus Phase 4 2003-01-01 2010-06-24
    NCT01744314 Elbow Trauma Requiring Operative Management Drug: Indomethacin and Pantoprazole|Drug: microcrystalline cellulose powder tablets Lawson Health Research Institute 2012-11-01 2017-03-22

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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