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Teicoplanin

替考拉宁,Teichomycin

Teicoplanin是一种预防用的抗生素。

目录号
EY0929
EY0929
EY0929
EY0929
纯度
99.16%
99.16%
99.16%
99.16%
规格
1 mg
5 mg
10 mg
50 mg
原价
115
240
342
520
售价
115
240
342
520
库存
现货
现货
现货
现货
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  • 生物活性

    Teicoplanin is a glycopeptide antibiotic. Teicoplanin Complex is a complex of antibiotics produced by Actinoplanes teichomyceticus. Teicoplanin is noted to prevent cell-wall synthesis via inhibition of petidoglycan polymerization. Teicoplanin has been reported to have effectiveness against gram-positive cocci in vitro, such as Staphylococcus epidermidis, Staphylococcus aureus and Enterococcus spp.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Samonis G, et al. Med Mycol,?006, 44(2), 193-196.
    [2] Verbist, L., et al. 1984. Antimicrob. Agents Chemother. 26: 881-886.
    [3] Babul, N. and Pasko, M. 1988. Drug Intell Clin Pharm. 22: 218-226.
    [4] Campoli-Richards, D.M., et al. 1990. Drugs. 40: 449-486.

    分子式
    C77H77N9O31Cl2·R    		 分子量
    1709.39    		 CAS号
    61036-62-2    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    <1 mg/mL    		 Water
    >10 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01815541 Osteoarticular Infection Drug: teicoplanin Centre Hospitalier Universitaire, Amiens Phase 2 2013-03-01 2016-08-01
    NCT00368498 Staphylococcal Infections Drug: teicoplanin National Taiwan University Hospital Phase 4 2006-06-01 2006-08-23
    NCT00454272 Infection|Febrile Neutropenia Drug: Teicoplanin|Drug: Vancomycin Sanofi Phase 4 2005-01-01 2009-03-05
    NCT03020901 Infectious Disease Drug: Teicoplanin for Injection Jiangsu Famous Medical Technology Co., Ltd. 2017-01-01 2017-01-11
    NCT00024453 Infection Biological: teicoplanin Children's Cancer and Leukaemia Group|National Cancer Institute (NCI) 1999-02-01 2013-08-06
    NCT00430937 Skin Diseases, Infectious|Soft Tissue Infections Drug: Daptomycin|Drug: Vancomycin|Drug: Teicoplanin Novartis Pharmaceuticals|Novartis Phase 3 2006-04-01 2012-07-10
    NCT01352936 Staphylococcus Aureus|Bacteremia Taipei Medical University WanFang Hospital 2011-01-01 2011-05-11
    NCT02581280 Cardiac Dysfunction Other: Residual blood Yonsei University 2014-12-01 2015-12-09
    NCT00925093 Neurosurgery Drug: Vancomycin|Drug: Teicoplanin|Drug: Linezolid Aarhus University Hospital Phase 1 2011-09-01 2015-01-23
    NCT00754273 Methicillin-resistant Staphylococcal Aureus Pneumonia Other: etest susceptability testing University of Kentucky|Pfizer 2008-09-01 2011-03-22
    NCT02652169 Chronic Skin Ulcer Drug: Platelet rich fibrin with amikacin and teicoplanin|Drug: Platelet rich fibrin with PHMB plus Macrogolol (Lavasorb(R))|Drug: Platelet rich fibrin plus sodium chloride 0.9%|Device: Acticoat 7 (R) Medical University of Vienna 2014-06-01 2016-01-07
    NCT01592032 Catheter-Related Infections|Bacteremia. Drug: Vancomycin antimicrobial-lock solution|Drug: Teicoplanin antimicrobial-lock solution|Drug: Linezolid antimicrobial-lock solution|Drug: Daptomycin antimicrobial-lock solution|Drug: Tigecycline antimicrobial-lock solution Clinica Universidad de Navarra, Universidad de Navarra|University of Navarrra Hospital (Clinica Universitaria) Phase 4 2012-05-01 2015-02-18
    NCT01324804 Coronary Heart Disease|Surgical Wound Infection Medical University of Vienna 2010-11-01 2011-03-28
    NCT00462878 Allogenic Blood Stem Cell Transplantation|Febrile Neutropenia Drug: Meropenem|Drug: Vancomycin|Drug: Teicoplanin PETHEMA Foundation 2002-11-01 2009-05-11
    NCT00428844 Osteomyelitis Drug: daptomycin|Drug: daptomycin|Drug: vancomycin|Drug: teicoplanin|Drug: nafcillin|Drug: oxacillin|Drug: flucloxacillin Cubist Pharmaceuticals LLC Phase 2 2007-01-01 2016-01-05
    NCT02018094 Wound Infection|Amputation Wound Drug: Co-amoxiclav|Drug: Iodine|Drug: Metronidazole|Drug: Chlorhexidine|Drug: Teicoplanin|Drug: Clindamycin University of Hull Phase 4 2013-10-01 2014-12-14
    NCT00427076 Staphylococcal Infections|Meningitis|Sepsis|Pneumonia Drug: Cotrimoxazole|Drug: Vancomycin Rabin Medical Center Phase 3 2007-06-01 2015-09-23
    NCT00368537 Skin Diseases, Bacterial Drug: Tigecycline|Drug: ampicillin-sulbactam Wyeth is now a wholly owned subsidiary of Pfizer Phase 4 2006-09-01 2012-08-08
    NCT02940730 Infectious Peritonitis Drug: Dalbavancin via Intravenous Administration|Drug: Dalbavancin via Intraperitoneal Administration University of Colorado, Denver Phase 4 2017-04-01 2017-03-02
    NCT02814916 Methicillin-Resistant Staphylococcus Aureus|Bacterial Infections|Staphylococcal Skin Infections Drug: Dalbavancin single dose|Drug: Dalbavancin two dose|Drug: Comparator Durata Therapeutics Inc., an affiliate of Allergan plc Phase 3 2016-06-01 2016-06-23
    NCT02688790 Bacterial Infections Drug: Dalbavancin Durata Therapeutics Inc., an affiliate of Allergan plc Phase 1 2016-04-01 2016-10-19
    NCT02685033 Osteomyelitis Drug: Dalbavancin|Drug: Comparator Durata Therapeutics Inc., an affiliate of Allergan plc Phase 2 2016-03-01 2016-10-18
    NCT02127970 Abscess|Wound Infection|Surgical Site Infection|Cellulitis Drug: Single Dose Dalbavancin|Drug: Two Dose Dalbavancin Durata Therapeutics Inc., an affiliate of Allergan plc Phase 3 2014-04-01 2016-05-11

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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